References in communication policy research: a bibliographical characterization of articles published by Spanish authors

This paper provides a characterization of the bibliographicalreferences of Spanish scientific articles in the field ofcommunication policy using a bibliometric approach. Itanalyses 93 articles published by authors from Spanishinstitutions between 2002 and 2011 in major Spanish journalsincluded on the communication section of both the IN RECSindex and the Social Sciences Citation Index. The paperexamines the main references used by Spanish communicationpolicy researchers and the typology of these references, theirSpanish or international character and the most cited authorsin this field. The results show the disparity and adaptability ofarticles depending on the scope of the journals in which theyare published. Thus, articles published in international journalscontain more than twice as many references as those appearingin Spanish journals. The typology is also different; articles arethe most common source in international journals while bookspredominate in Spanish journals. These results are analyzed inthe context of the institutionalized practices of scientificproduction approved by university assessment agencies; theseare compared with the actual practices of researchers throughan analysis of the main bibliographical references

RTVE’s transmedia strategy aimed at young audiences: the case of Playz (2017-2020)

Generally speaking, audio-visual consumption is changing. More specifically, in recent years young people have increased their viewing of content through the Internet, which is often supplied through online platforms. This article focuses on one the Playz platform, which is one of the key strategies being used by Spanish public television (RTVE), as it aims to reconnect with the new generations through transmedia narratives. Based on studies undertaken by Costa Sánchez (2013) and Cascajosa-Virino (2018), a content analysis of the series broadcast on Playz between 2017 and 2020 has been carried out, taking into account the duration, year of release, and number of episodes or seasons for each of them. This study confirms a clear interest by this platform in generating products that are innovative from their very conception. In fact, a large number of transmedia strategies have been identified, such as episodes turned into films, a high degree of interactivity with the audience, original music videos, promotional events and more, which is in line with Playz’s public service obligation to reach out to all types of audiences through all the platforms available to them.El consumo audiovisual está cambiando de manera general y, en concreto, la juventud ha incrementado durante los últimos años el visionado de contenidos a través de Internet, a menudo servidos a través de plataformas online. Este artículo se centra en una de esas, Playz, una pieza estratégica de la televisión pública española (RTVE), en su objetivo de reconectar con las nuevas generaciones a través de narrativas transmedia. Partiendo de los estudios acometidos por Costa Sánchez (2013) y por Cascajosa-Virino (2018), se ha realizado un análisis del contenido de las series de Playz entre 2017 y 2020, y se han tenido en cuenta desde la temática, hasta la duración, pasando por el número de capítulos o de temporadas de cada una de ellas. Este trabajo muestra el claro interés de esta plataforma por generar productos innovadores desde su misma concepción. De hecho, se han identificado un gran número de estrategias transmedia (capítulos convertidos en películas, alto grado de interactividad con la audiencia, vídeos musicales originales, actos promocionales…), que siguen la línea de la obligación de servicio público de Playz de acercarse a toda clase de público y desde todas las plataformas puestas a su alcance

European Multidisciplinary and Water-Column Observatory - European Research Infrastructure Consortium (EMSO ERIC): challenges and opportunities for strategic European marine sciences

EMSO (European Multidisciplinary Seafloor and water-column Observatory, www.emso-eu.org) is a large‐scale European Research Infrastructure I. It is a distributed infrastructure of strategically placed, deep‐sea seafloor and water column observatory nodes with the essential scientific objective of real‐time, longterm observation of environmental processes related to the interaction between the geosphere, biosphere, and hydrosphere. The geographic locations of the EMSO observatory nodes represent key sites in European waters, from the Arctic, through the Atlantic and Mediterranean, to the Black Sea (Figure 1), as defined through previous studies performed in FP6 and FP7 EC projects such as ESONET‐CA, ESONET‐NoE, EMSO-PP (Person et al., 2015)Peer Reviewe

Sistema de inspección mediante imágenes de luminiscencia de módulos solares en funcionamiento

CIES2020 - XVII Congresso Ibérico e XIII Congresso Ibero-americano de Energia SolarRESUMEN: Los avances en la detección de defectos en módulos fotovoltaicos por luminiscencia se están viendo demorados por la necesidad que las técnicas de inspección actuales tienen de actuar sobre los contactos eléctricos y retirar los paneles de su estado de funcionamiento. En el presente trabajo se introduce un sistema que vence esta limitación, pudiendo tomar imágenes de luminiscencia sobre módulos solares en funcionamiento. Dicho sistema se pone a prueba mediante la implementación de un primer prototipo funcional, con el que se toman imágenes de un string de células completo para poder compararlas con las obtenidas utilizando las técnicas de inspección actuales, determinando así sus similitudes y diferencias, y corroborando la validez del método propuesto.ABSTRACT: Advances in the detection of defects in photovoltaic modules by luminescence are being delayed by the need that current inspection techniques have to act on the electrical contacts and remove the panels from their operating state. In the present work, a system is introduced that overcomes this limitation, being able to take images of luminescence on solar modules in operation. This system is put to the test by implementing a first functional prototype, with which images are taken of a complete string of cells to be able to compare them with those obtained using current inspection techniques, thus determining their similarities and differences, and corroborating the validity of the proposed method.info:eu-repo/semantics/publishedVersio

The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma

Aberrant SRC expression and activation is frequently detected in multiple cancers, and hence, targeting SRC has emerged as a promising therapeutic strategy. Different SRC inhibitors have demonstrated potent anti-tumor activity in preclinical models, although they largely lack clinical efficacy as monotherapy in late-stage solid tumors, including head and neck squamous cell carcinomas (HNSCC). Adequate selection and stratification of patients who may respond to and benefit from anti-SRC therapies is therefore needed to guide clinical trials and treatment efficacy. This study investigates the prognostic significance of active SRC expression in a homogeneous cohort of 122 human papillomavirus (HPV)-negative, surgically treated HNSCC patients. Immunohistochemical evaluation of the active form of SRC by means of anti-SRC Clone 28 monoclonal antibody was specifically performed and subsequently correlated with clinical data. The expression of p-SRC (Tyr419), total SRC, and downstream SRC effectors was also analyzed. Our results uncovered striking differences in the prognostic relevance of SRC expression in HNSCC patients depending on the tumor site. Active SRC expression was found to significantly associate with advanced disease stages, presence of lymph node metastasis, and tumor recurrences in patients with laryngeal tumors, but not in the pharyngeal subgroup. Multivariate Cox analysis further revealed active SRC expression as an independent predictor of cancer-specific mortality in patients with laryngeal carcinomas. Concordantly, expression of p-SRC (Tyr419) and the SRC substrates focal adhesion kinase (FAK) and the Arf GTPase-activating protein ASAP1 also showed specific associations with poor prognosis in the larynx. These findings could have important implications in ongoing Src family kinase (SFK)-based clinical trials, as these new criteria could help to improve patient selection and develop biomarker-stratified trials

External validation of multidimensional prognostic indices (ADO, BODEx and DOSE) in a primary care international cohort (PROEPOC/COPD cohort)

Background: Due to the heterogeneous and systemic nature of the chronic obstructive pulmonary disease (COPD), the new guidelines are oriented toward individualized attention. Multidimensional scales could facilitate its proper clinical and prognostic assessment, but not all of them were validated in an international primary care cohort, different from the original ones used for model development. Therefore, our main aim is to assess the prognostic capacity of the ADO, BODEx and DOSE indices in primary care for predicting mortality in COPD patients and to validate the models obtained in subgroups of patients, classified by revised Global Initiative for Chronic Obstructive Lung Disease (2011) and updated Spanish Guideline (2014). Besides, we want to confirm that the prognostic capacity of all indices increases if the number of exacerbations is substituted by the interval between them and to assess the impact on health of the patient''s lifestyle, social network and adherence to treatment. Methods: Design: External validation of scales, open and prospective cohort study in primary care. Setting: 36 health centres in 6 European high, medium and low income countries. Subjects: 477 patients diagnosed with COPD, captured in clinical visit by their General Practitioner/Nurse. Predictors: Detailed patient history, exacerbations, lung function test and questionnaires at baseline. Outcomes: Exacerbations, all-cause mortality and specific mortality, within 5 years of recruitment. Analysis: Multivariate logistic regression and Cox regression will be used. Possible non-linear effect of the indices will be studied by using Structured Additive Regression models with penalised splines. Subsequently, we will assess different aspects of the regression models: discrimination, calibration and diagnostic precision. Clinical variables modulated in primary care and the interval between exacerbations will be considered and incorporated into the analysis. Discussion: The Research Agenda for General Practice/Family Medicine highlights that the evidence on predictive values of prognostic indices in primary care is scarce. A prospective cohort like that of PROEPOC/COPD provides good opportunities for research into COPD and make communication easier between family practitioners, nursing staff, pneumologists and other professionals, supporting a multi-disciplinary approach to the treatment of these patients. Trial registration:ISRCTN52402811. Date: 15/01/2015. Prospectively registered

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-based treatment regimens, often because of drug resistance-associated substitutions (RAS). The aim of this study was to characterize the resistance profile of a large cohort of patients failing DAA-based treatments, and investigate the relationship between HCV subtype and failure, as an aid to optimizing management of these patients. A new, standardized HCV-RAS testing protocol based on deep sequencing was designed and applied to 220 previously subtyped samples from patients failing DAA treatment, collected in 39 Spanish hospitals. The majority had received DAA-based interferon (IFN) a-free regimens; 79% had failed sofosbuvir-containing therapy. Genomic regions encoding the nonstructural protein (NS) 3, NS5A, and NS5B (DAA target regions) were analyzed using subtype-specific primers. Viral subtype distribution was as follows: genotype (G) 1, 62.7%; G3a, 21.4%; G4d, 12.3%; G2, 1.8%; and mixed infections 1.8%. Overall, 88.6% of patients carried at least 1 RAS, and 19% carried RAS at frequencies below 20% in the mutant spectrum. There were no differences in RAS selection between treatments with and without ribavirin. Regardless of the treatment received, each HCV subtype showed specific types of RAS. Of note, no RAS were detected in the target proteins of 18.6% of patients failing treatment, and 30.4% of patients had RAS in proteins that were not targets of the inhibitors they received. HCV patients failing DAA therapy showed a high diversity of RAS. Ribavirin use did not influence the type or number of RAS at failure. The subtype-specific pattern of RAS emergence underscores the importance of accurate HCV subtyping. The frequency of “extra-target” RAS suggests the need for RAS screening in all three DAA target regions

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research