Reconfiguración de la forma urbana de centralidades tradicionales en Bogotá. Caso: proyecto centro de Fontibón

El propósito de este Trabajo Final de Maestría consiste en demostrar como por medio del proyecto urbano se pueden intervenir los centros tradicionales periféricos de Bogotá en éste caso el centro de Fontibón; ofreciendo nuevas herramientas cualitativas para reconfigurar y renovar los espacios representativos de éstas piezas urbanas, integrando éste centro con su contexto (Bogotá y la sabana), caracterizado por ser un elemento aislado producto de los cambios ocurridos a mitad del siglo XX, el cual yuxtapuso un tejido rectangular tradicional con otros tejidos de origen espontáneo, mostrando una desarticulación espacial y formal de éste centro con el territorio.Abstract. The purpose of this Master's Final Work consists of demonstrating how through the urban project can intervene in traditional peripheral centers of Bogotá, in this case the center of Fontibón: offering new qualitative tools to reconfigure and renew the representative spaces of these urban pieces, integrating this center, characterized by be an outlying element product of the changes, these occurred to half of the 20th century, which juxtaposed a traditional rectangular tissue “fabric” with others spontaneous origin’s tissues, showing a spatial and formal disarticulation of this center with the territory.Maestrí

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality