The online world as a means of connection and disconnection during the COVID-19 pandemic: A test of the interpersonal-connections-behaviour framework

BACKGROUND: The interpersonal-connections-behaviour framework proposes that social media is helpful/unhelpful to the individual to the extent that it facilitates/hinders satisfaction of core needs for acceptance and belonging (connecting and disconnecting pathways). However, little research has, to date, explicitly tested this framework. METHODS: Both pathways were explored in a cross-sectional sample of UK adults at the start of the pandemic (N = 632) and in longitudinal (cross-lagged) analyses (N = 227-240). Participants completed measures of online and offline socialising with friends and family (connecting pathway), and online and offline social comparisons (disconnecting pathway), anxiety, depression and loneliness. RESULTS: In cross-sectional analyses higher levels of online comparisons were associated with poorer mental health, an effect that survived after controlling for offline comparisons, and was partially mediated by loneliness. Counter to our predictions, online socialising was also associated with poorer mental health. Longitudinal analyses did not support predicted directions of causality. LIMITATIONS: Limitations include a lack of testing of individual-level moderators, the use of single item questions to probe some constructs, and an inability to test for effects potentially operating at different time-scales. CONCLUSIONS: The findings reported partially support the interpersonal-connections-behaviour framework in highlighting a disconnecting (but not connecting) pathway between online engagement and mental health. From a clinical perspective they highlight the importance of including people's online lives when considering mental health risk and resilience, particularly (one might argue) during periods of social isolation

Can children measure their own vision? A comparison of three new contrast sensitivity tests

PURPOSE: To investigate the feasibility of children measuring their own contrast sensitivity using a range of tablet- and paper-based tests. METHODS: Forty children aged 5-15 years with amblyopia (N = 10), bilateral vision impairment (N = 10) or good vision (N = 20) measured their own vision on a screen-based optotype test (Manifold), a gamified vision test (PopCSF) and a paper-based test (Spotchecks) in a laboratory with minimal supervision. Completion rate, test-retest repeatability, test duration and participants' preferences were recorded for each test. RESULTS: Most participants (36/40) were able to perform all three tests. All tests were correlated with clinically measured visual acuity and contrast sensitivity (p < 0.001). The 95% coefficient of repeatability was 0.30 dB for Manifold, 0.29 dB for PopCSF and 0.13 dB for Spotchecks. All tests differentiated between children with reduced contrast sensitivity and control participants. PopCSF and Spotchecks were also able to differentiate between children with amblyopia and those with good vision. Median test time was 152, 130 and 202 s for Manifold, PopCSF and Spotchecks, respectively. Twenty-two participants preferred the PopCSF test, 10 preferred Spotchecks and 6 preferred Manifold. Thirty-nine out of the 40 children (98%) said they would measure their own vision at home using at least one of these tests every month. CONCLUSIONS: Children and young people can test their own contrast sensitivity with repeatable results. Of these three tests, the most repeatable was Spotchecks, the quickest was PopCSF and participants' favourite was PopCSF. Nearly all of the participants said they would be willing to use at least one of the three tests at home

The association between sociodemographic inequalities, COVID-related impacts and mental health

PURPOSE: There are concerns that the social, economic and health impacts of COVID-19 are unevenly distributed, exacerbating existing inequalities. Here we tested the hypotheses that: (H1) the magnitude of these impacts would be associated with symptoms of depression and anxiety early in the pandemic, and (H2) that these impacts would be associated with a range of sociodemographic risk factors. METHODS: Cross-sectional self-report data were collected from a UK sample (N = 632) between the 16th of May and 21st of July 2020, coinciding with the early stages of the pandemic and first UK lockdown. Data were collected on COVID-19 related impacts including financial and social stressors, symptoms of anxiety and depression, and sociodemographic/economic risk factors operationalised at multiple levels including the individual, familial, household and neighbourhood. RESULTS: Using regression analyses both financial and social impacts were independently associated with anxiety (R2 = 0.23) and depression scores (R2 = 0.24), as well as clinically significant generalised anxiety (R2 = 0.14) and depression (R2 = 0.11). In addition, many sociodemographic factors were associated with elevated levels of COVID-19 related impacts, including being younger, female, having lower educational attainment and lower income. LIMITATIONS: The main limitations of the study were its modest sample size, cross sectional design (which precluded inferences about directions of causality), and the relatively high socioeconomic status of the sample (which limited generalisability). CONCLUSIONS: These findings are consistent with a growing body of evidence that suggests that the pandemic has exacerbated existing inequalities, and further, point to particular groups that should be supported by post-COVID-19 recovery policies and initiatives

Quantifying agent impacts on contact sequences in social interactions

Human social behavior plays a crucial role in how pathogens like SARS-CoV-2 or fake news spread in a population. Social interactions determine the contact network among individuals, while spreading, requiring individual-to-individual transmission, takes place on top of the network. Studying the topological aspects of a contact network, therefore, not only has the potential of leading to valuable insights into how the behavior of individuals impacts spreading phenomena, but it may also open up possibilities for devising effective behavioral interventions. Because of the temporal nature of interactions - since the topology of the network, containing who is in contact with whom, when, for how long, and in which precise sequence, varies (rapidly) in time - analyzing them requires developing network methods and metrics that respect temporal variability, in contrast to those developed for static (i.e., time-invariant) networks. Here, by means of event mapping, we propose a method to quantify how quickly agents mingle by transforming temporal network data of agent contacts. We define a novel measure called 'contact sequence centrality', which quantifies the impact of an individual on the contact sequences, reflecting the individual's behavioral potential for spreading. Comparing contact sequence centrality across agents allows for ranking the impact of agents and identifying potential 'behavioral super-spreaders'. The method is applied to social interaction data collected at an art fair in Amsterdam. We relate the measure to the existing network metrics, both temporal and static, and find that (mostly at longer time scales) traditional metrics lose their resemblance to contact sequence centrality. Our work highlights the importance of accounting for the sequential nature of contacts when analyzing social interactions

The debate on screen time: An empirical case study in infant-directed video

This chapter presents data on how infants interact with educational videos, collected using sensitive eye-tracking measures of attention. It describes the ongoing Toddler Attentional Behaviours and Learning with Touchscreens (TABLET) Project, developed by Annette Karmiloff-Smith with Rachael Bedford and Tim J. Smith. The chapter presents some detailed empirical work that illustrates the kinds of methods Annette believed were needed to ground an evidence-based approach to understanding the impact of screen time on infant development. Annette was a great pragmatist who understood the importance of working with parents, media producers, and policy-makers, to find the best ways for infants to benefit from scientific insights into development. She decided to collaborate with Abbey Media to develop infant-directed DVD content designed specifically with infant cognitive research in mind. TABLET is ongoing project aiming to test whether infant exposure to touchscreen devices at 12 months-of-age is associated with long-term developmental differences at 18 and 42 months-of-age in domains including attention, temperament, developmental milestones, language, executive function and sleep

Discrete confidence levels revealed by sequential decisions

Humans can meaningfully express their confidence about uncertain events. Normatively, these beliefs should correspond to Bayesian probabilities. However, it is unclear whether the normative theory provides an accurate description of the human sense of confidence, partly because the self-report measures used in most studies hinder quantitative comparison with normative predictions. To measure confidence objectively, we developed a dual-decision task in which the correctness of a first decision determines the correct answer of a second decision, thus mimicking real-life situations in which confidence guides future choices. While participants were able to use confidence to improve performance, they fell short of the ideal Bayesian strategy. Instead, behaviour was better explained by a model with a few discrete confidence levels. These findings question the descriptive validity of normative accounts, and suggest that confidence judgments might be based on point estimates of the relevant variables, rather than on their full probability distributions

Comparison of Two Respiratory Support Strategies for Stabilization of Very Preterm Infants at Birth: A Matched-Pairs Analysis

Objective: Respiratory support for stabilizing very preterm infants at birth varies between centers. We retrospectively compared two strategies that involved either increasing continuous positive airway pressures (CPAP), or increasing oxygen supplementation.Methods: Matched-pairs of infants (&lt;28 weeks of gestation) were born either at the Leiden University Medical Center [low-pressure: CPAP 5–8 cmH2O and/or positive pressure ventilation (PPV) and fraction of inspired oxygen (FiO2) 0.3–1.0; n = 27], or at the University Hospital of Cologne (high-pressure: CPAP 12–35 cmH2O, no PPV and FiO2 0.3–0.4; n = 27). Respiratory support was initiated non-invasively via facemask at both units. Infants (n = 54) were matched between centers for gestational age and birth weight, to compare physiological and short-term clinical outcomes.Results: In the low-pressure group, 20/27 (74%) infants received 1–2 sustained inflations (20, 25 cm H2O) and 22/27 (81%) received PPV (1:19–3:01 min) using pressures of 25–27 cm H2O. Within 3 min of birth [median (IQR)], mean airway pressures [12 (6–15) vs. 19 (16–23) cmH2O, p &lt; 0.001] and FiO2 [0.30 (0.28–0.31) vs. 0.22 (0.21–0.30), p &lt; 0.001] were different in low- vs. high-pressure groups, respectively. SpO2 and heart rates were similar. After 3 min, higher FiO2 levels [0.62 (0.35–0.98) vs. 0.28 (0.22–0.38), p = 0.005] produced higher SpO2 levels [77 (50–92) vs. 53 (42–69)%, p &lt; 0.001] in the low-pressure group, but SpO2/FiO2 and heart rates were similar. While intubation rates during admission were significantly different (70 vs. 30%, p = 0.013), pneumothorax rates (4 vs. 19%, p = 0.125) and the occurrence of spontaneous intestinal perforations (0 vs. 15%, p = 0.125) were similar between groups.Conclusion: Infants (&lt;28 weeks) can be supported non-invasively at birth with either higher or lower pressures and while higher-pressure support may require less oxygen, it does not eliminate the need for oxygen supplementation. Future studies need to examine the effect of high pressures and pressure titration in the delivery room

Increasing Respiratory Effort With 100% Oxygen During Resuscitation of Preterm Rabbits at Birth

Background: Spontaneous breathing is essential for successful non-invasive respiratory support delivered by a facemask at birth. As hypoxia is a potent inhibitor of spontaneous breathing, initiating respiratory support with a high fraction of inspired O2 may reduce the risk of hypoxia and increase respiratory effort at birth. Methods: Preterm rabbit kittens (29 days gestation, term ~32 days) were delivered and randomized to receive continuous positive airway pressure with either 21% (n = 12) or 100% O2 (n = 8) via a facemask. If apnea occurred, intermittent positive pressure ventilation (iPPV) was applied with either 21% or 100% O2 in kittens who started in 21% O2, and remained at 100% O2 for kittens who started the experiment in 100% O2. Respiratory rate (breaths per minute, bpm) and variability in inter-breath interval (%) were measured from esophageal pressure recordings and functional residual capacity (FRC) was measured from synchrotron phase-contrast X-ray images. Results: Initially, kittens receiving 21% O2 had a significantly lower respiratory rate and higher variability in inter-breath interval, indicating a less stable breathing pattern than kittens starting in 100% O2 [median (IQR) respiratory rate: 16 (4–28) vs. 38 (29–46) bpm, p = 0.001; variability in inter-breath interval: 33.3% (17.2–50.1%) vs. 27.5% (18.6–36.3%), p = 0.009]. Apnea that required iPPV, was more frequently observed in kittens in whom resuscitation was started with 21% compared to 100% O2 (11/12 vs. 1/8, p = 0.001). After recovering from apnea, respiratory rate was significantly lower and variability in inter-breath interval was significantly higher in kittens who received iPPV with 21% compared to 100% O2. FRC was not different between study groups at both timepoints. Conclusion: Initiating resuscitation with 100% O2 resulted in increased respiratory activity and stability, thereby reducing the risk of apnea and need for iPPV after birth. Further studies in human preterm infants are mandatory to confirm the benefit of this approach in terms of oxygenation. In addition, the ability to avoid hyperoxia after initiation of resuscitation with 100% oxygen, using a titration protocol based on oxygen saturation, needs to be clarified

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2

Background: Glioblastoma is the most malignant tumor of the central nervous system and still lacks effective treatment. This study explores mutational biomarkers of 11 drugs targeting either the RTK/Ras/PI3K, the p53 or the Rb pathway using 25 patient-derived glioblastoma stem-like cell cultures (GSCs). Results: We found that TP53 mutated GSCs were approximately 3.5 fold more sensitive to dual inhibition of mammalian target of rapamycin complex 1 and 2 (mTORC1/2) compared to wild type GSCs. We identified that Bcl-2(Thr56/Ser70) phosphorylation contributed to the resistance of TP53 wild type GSCs against dual mTORC1/2 inhibition. The Bcl-2 inhibitor ABT-263 (navitoclax) increased sensitivity to the mTORC1/2 inhibitor AZD8055 in TP53 wild type GSCs, while sensitivity to AZD8055 in TP53 mutated GSCs remained unchanged. Conclusion: Our data suggest that Bcl-2 confers resistance to mTORC1/2 inhibitors in TP53 wild type GSCs and that combined inhibition of both mTORC1/2 and Bcl-2 is worthwhile to explore further in TP53 wild type glioblastomas, whereas in TP53 mutated glioblastomas dual mTORC1/2 inhibitors should be explored