Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD.

Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood. Here we examined the neural representations of sensory perception in the neocortex of a Shank3B-/- mouse model of ASD. Male and female Shank3B-/- mice were more sensitive to relatively weak tactile stimulation in a vibrissa motion detection task. In vivo population calcium imaging in vibrissa primary somatosensory cortex (vS1) revealed increased spontaneous and stimulus-evoked firing in pyramidal neurons but reduced activity in interneurons. Preferential deletion of Shank3 in vS1 inhibitory interneurons led to pyramidal neuron hyperactivity and increased stimulus sensitivity in the vibrissa motion detection task. These findings provide evidence that cortical GABAergic interneuron dysfunction plays a key role in sensory hyper-reactivity in a Shank3 mouse model of ASD and identify a potential cellular target for exploring therapeutic interventions

The AyA_y Puzzle and the Nuclear Force

The nucleon-deuteron analyzing power $A_y$ in elastic nucleon-deuteron scattering poses a longstanding puzzle. At energies $E_{lab}$ below approximately 30 MeV $A_y$ cannot be described by any realistic NN force. The inclusion of existing three-nucleon forces does not improve the situation. Because of recent questions about the $^3P_J$ NN phases, we examine whether reasonable changes in the NN force can resolve the puzzle. In order to do this we investigate the effect on the $^3P_J$ waves produced by changes in different parts of the potential (viz., the central force, tensor force, etc.), as well as on the 2-body observables and on $A_y$. We find that it is not possible with reasonable changes in the NN potential to increase the 3-body $A_y$ and at the same time to keep the 2-body observables unchanged. We therefore conclude that the $A_y$ puzzle is likely to be solved by new three-nucleon forces, such as those of spin-orbit type, which have not yet been taken into account.Comment: 35 pages in REVTeX, 1 figure in postscript and 3 figures in PiCTe

Does The 3N-Force Have A Hard Core?

The meson-nucleon dynamics that generates the hard core of the RuhrPot two-nucleon interaction is shown to vanish in the irreducible 3N force. This result indicates a small 3N force dominated by conventional light meson-exchange dynamics and holds for an arbitrary meson-theoretic Lagrangian. The resulting RuhrPot 3N force is defined in the appendix. A completely different result is expected when the Tamm-Dancoff/Bloch-Horowitz procedure is used to define the NN and 3N potentials. In that approach, (e.g. full Bonn potential) both the NN {\it and} 3N potentials contain non-vanishing contributions from the coherent sum of meson-recoil dynamics and the possibility of a large hard core requiring explicit calculation cannot be ruled out.Comment: 16 pages REVTeX + 3 ps fig

Composite vertices that lead to soft form factors

The momentum-space cut-off parameter $\Lambda$ of hadronic vertex functions is studied in this paper. We use a composite model where we can measure the contributions of intermediate particle propagations to $\Lambda$. We show that in many cases a composite vertex function has a much smaller cut-off than its constituent vertices, particularly when light constituents such as pions are present in the intermediate state. This suggests that composite meson-baryon-baryon vertex functions are rather soft, i.e., they have \Lambda considerably less than 1 GeV. We discuss the origin of this softening of form factors as well as the implications of our findings on the modeling of nuclear reactions.Comment: REVTex, 19 pages, 5 figs(to be provided on request

Triton calculations with π\pi and ρ\rho exchange three-nucleon forces

The Faddeev equations are solved in momentum space for the trinucleon bound state with the new Tucson-Melbourne $\pi$ and $\rho$ exchange three-nucleon potentials. The three-nucleon potentials are combined with a variety of realistic two-nucleon potentials. The dependence of the triton binding energy on the $\pi NN$ cut-off parameter in the three-nucleon potentials is studied and found to be reduced compared to the case with pure $\pi$ exchange. The $\rho$ exchange parts of the three-nucleon potential yield an overall repulsive effect. When the recommended parameters are employed, the calculated triton binding energy turns out to be very close to its experimental value. Expectation values of various components of the three-nucleon potential are given to illustrate their significance for binding.Comment: 17 pages Revtex 3.0, 4 figures. Accepted for publication in Phys. Rev.

Momentum and Coordinate Space Three-nucleon Potentials

In this paper we give explicit formulae in momentum and coordinate space for the three-nucleon potentials due to $\rho$ and $\pi$ meson exchange, derived from off-mass-shell meson-nucleon scattering amplitudes which are constrained by the symmetries of QCD and by the experimental data. Those potentials have already been applied to nuclear matter calculations. Here we display additional terms which appear to be the most important for nuclear structure. The potentials are decomposed in a way that separates the contributions of different physical mechanisms involved in the meson-nucleon amplitudes. The same type of decomposition is presented for the $\pi - \pi$ TM force: the $\Delta$, the chiral symmetry breaking and the nucleon pair terms are isolated.Comment: LATEX, 33 pages, 3 figures (available as postscript files upon request

Building the genomic nation: ‘Homo Brasilis’ and the ‘Genoma Mexicano’ in comparative cultural perspective

This article explores the relationship between genetic research, nationalism and the construction of collective social identities in Latin America. It makes a comparative analysis of two research projects – the ‘Genoma Mexicano’ and the ‘Homo Brasilis’ – both of which sought to establish national and genetic profiles. Both have reproduced and strengthened the idea of their respective nations of focus, incorporating biological elements into debates on social identities. Also, both have placed the unifying figure of the mestizo/mestiço at the heart of national identity constructions, and in so doing have displaced alternative identity categories, such as those based on race. However, having been developed in different national contexts, these projects have had distinct scientific and social trajectories: in Mexico, the genomic mestizo is mobilized mainly in relation to health, while in Brazil the key arena is that of race. We show the importance of the nation as a frame for mobilizing genetic data in public policy debates, and demonstrate how race comes in and out of focus in different Latin American national contexts of genomic research, while never completely disappearing

Role of Vector Mesons in High-Q^2 Lepton-Nucleon Scattering

The possible role played by vector mesons in inclusive deep inelastic lepton-nucleon scattering is investigated. In the context of the convolution model, we calculate self-consistently the scaling contribution to the nucleon structure function using the formalism of time-ordered perturbation theory in the infinite momentum frame. Our results indicate potentially significant effects only when the vector meson---nucleon form factor is very hard. Agreement with the experimental antiquark distributions, however, requires relatively soft form factors for the $\pi N$, $\rho N$ and $\omega N$ vertices.Comment: 22 pages, 9 figures (available upon request); accepted for publication in Phys.Rev.D, ADP-92-197/T12