Talker identification is not improved by lexical access in the absence of familiar phonology

Listeners identify talkers more accurately when they are familiar with both the sounds and words of the language being spoken. It is unknown whether lexical information alone can facilitate talker identification in the absence of familiar phonology. To dissociate the roles of familiar words and phonology, we developed English-Mandarin “hybrid” sentences, spoken in Mandarin, which can be convincingly coerced to sound like English when presented with corresponding subtitles (e.g., “wei4 gou3 chi1 kao3 li2 zhi1” becomes “we go to college”). Across two experiments, listeners learned to identify talkers in three conditions: listeners' native language (English), an unfamiliar, foreign language (Mandarin), and a foreign language paired with subtitles that primed native language lexical access (subtitled Mandarin). In Experiment 1 listeners underwent a single session of talker identity training; in Experiment 2 listeners completed three days of training. Talkers in a foreign language were identified no better when native language lexical representations were primed (subtitled Mandarin) than from foreign-language speech alone, regardless of whether they had received one or three days of talker identity training. These results suggest that the facilitatory effect of lexical access on talker identification depends on the availability of familiar phonological forms

If you want to kiss her, kiss her! Gender and Queer Time in modern Meisner training

Responses to creating trainings for LGBTQ + and other marginalized student groups tend either toward rejecting acting ‘methods’ as unfit for purpose, or to simply changing pronouns in these trainings and carrying on as before. This article works through an encounter with heteronormative gender ideology in the Meisner technique. It looks at the way the training and the trainer support the normative and shut down the ability for students to act on the Meisner instruction to ‘bring the actor back to his emotional impulses and to acting firmly rooted in the instinctive’. It considers a repositioning of the Meisner repetition exercise as an example and experience of Halberstam (2005) and McCallam and Tuhkanen’s (2011) formulations of ‘Queer Time’ in order to problematize the role of the trainer as ‘guru’ or ‘charismatic teacher’ and normative ‘time keeper’ and thereby to create training in which students are free not to follow hegemonic cultural behaviour patterns. We posit that this ‘queer Meisner time’ might be used in order to foster atmospheres in which students who do not conform to gender and sexual norms might not encounter these restrictive hegemonies

A Systematic Review of Research on Augmentative and Alternative Communication Brain-Computer Interface Systems for Individuals with Disabilities.

Augmentative and alternative communication brain-computer interface (AAC-BCI) systems are intended to offer communication access to people with severe speech and physical impairment (SSPI) without requiring volitional movement. As the field moves toward clinical implementation of AAC-BCI systems, research involving participants with SSPI is essential. Research has demonstrated variability in AAC-BCI system performance across users, and mixed results for comparisons of performance for users with and without disabilities. The aims of this systematic review were to (1) describe study, system, and participant characteristics reported in BCI research, (2) summarize the communication task performance of participants with disabilities using AAC-BCI systems, and (3) explore any differences in performance for participants with and without disabilities. Electronic databases were searched in May, 2018, and March, 2021, identifying 6065 records, of which 73 met inclusion criteria. Non-experimental study designs were common and sample sizes were typically small, with approximately half of studies involving five or fewer participants with disabilities. There was considerable variability in participant characteristics, and in how those characteristics were reported. Over 60% of studies reported an average selection accuracy ≤70% for participants with disabilities in at least one tested condition. However, some studies excluded participants who did not reach a specific system performance criterion, and others did not state whether any participants were excluded based on performance. Twenty-nine studies included participants both with and without disabilities, but few reported statistical analyses comparing performance between the two groups. Results suggest that AAC-BCI systems show promise for supporting communication for people with SSPI, but they remain ineffective for some individuals. The lack of standards in reporting outcome measures makes it difficult to synthesize data across studies. Further research is needed to demonstrate efficacy of AAC-BCI systems for people who experience SSPI of varying etiologies and severity levels, and these individuals should be included in system design and testing. Consensus in terminology and consistent participant, protocol, and performance description will facilitate the exploration of user and system characteristics that positively or negatively affect AAC-BCI use, and support innovations that will make this technology more useful to a broader group of people

A systematic review of research on augmentative and alternative communication brain-computer interface systems for individuals with disabilities

Augmentative and alternative communication brain-computer interface (AAC-BCI) systems are intended to offer communication access to people with severe speech and physical impairment (SSPI) without requiring volitional movement. As the field moves toward clinical implementation of AAC-BCI systems, research involving participants with SSPI is essential. Research has demonstrated variability in AAC-BCI system performance across users, and mixed results for comparisons of performance for users with and without disabilities. The aims of this systematic review were to (1) describe study, system, and participant characteristics reported in BCI research, (2) summarize the communication task performance of participants with disabilities using AAC-BCI systems, and (3) explore any differences in performance for participants with and without disabilities. Electronic databases were searched in May, 2018, and March, 2021, identifying 6065 records, of which 73 met inclusion criteria. Non-experimental study designs were common and sample sizes were typically small, with approximately half of studies involving five or fewer participants with disabilities. There was considerable variability in participant characteristics, and in how those characteristics were reported. Over 60% of studies reported an average selection accuracy ≤70% for participants with disabilities in at least one tested condition. However, some studies excluded participants who did not reach a specific system performance criterion, and others did not state whether any participants were excluded based on performance. Twenty-nine studies included participants both with and without disabilities, but few reported statistical analyses comparing performance between the two groups. Results suggest that AAC-BCI systems show promise for supporting communication for people with SSPI, but they remain ineffective for some individuals. The lack of standards in reporting outcome measures makes it difficult to synthesize data across studies. Further research is needed to demonstrate efficacy of AAC-BCI systems for people who experience SSPI of varying etiologies and severity levels, and these individuals should be included in system design and testing. Consensus in terminology and consistent participant, protocol, and performance description will facilitate the exploration of user and system characteristics that positively or negatively affect AAC-BCI use, and support innovations that will make this technology more useful to a broader group of people.Clinical trial registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018095345, PROSPERO: CRD42018095345

Screening mammography uptake within Australia and Scotland in rural and urban populations

Objective. To test the hypothesis that rural populations had lower uptake of screening mammography thanurban populations in the Scottish and Australian setting.Method. Scottish data are based upon information from the Scottish Breast Screening Programme Information System describing uptake among women residing within the NHS Highland Health Board area who were invitedto attend for screening during the 2008 to 2010 round (N = 27,416). Australian data were drawn from the 2010survey of the 1946–51 cohort of the Australian Longitudinal Study on Women's Health (N = 9890 women).Results. Contrary to our hypothesis, results indicated that women living in rural areas were not less likely toattend for screening mammography compared to women living in urban areas in both Scotland (OR for rural =1.17, 95% CI = 1.06–1.29) and Australia (OR for rural = 1.15, 95% CI = 1.01–1.31).Conclusions. The absence of rural–urban differences in attendance at screening mammography demonstratesthat rurality is not necessarily an insurmountable barrier to screening mammograph

Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern [version 2; referees: 2 approved]

Background: Malaria parasite species differ greatly in the harm they do to humans. While P. falciparum kills hundreds of thousands per year, P. vivax kills much less often and P. malariae is relatively benign. Strains of the rodent malaria parasite Plasmodium chabaudi show phenotypic variation in virulence during infections of laboratory mice. This make it an excellent species to study genes which may be responsible for this trait. By understanding the mechanisms which underlie differences in virulence we can learn how parasites adapt to their hosts and how we might prevent disease. Methods: Here we present a complete reference genome sequence for a more virulent P. chabaudi strain, PcCB, and perform a detailed comparison with the genome of the less virulent PcAS strain. Results: We found the greatest variation in the subtelomeric regions, in particular amongst the sequences of the pir gene family, which has been associated with virulence and establishment of chronic infection. Despite substantial variation at the sequence level, the repertoire of these genes has been largely maintained, highlighting the requirement for functional conservation as well as diversification in host-parasite interactions. However, a subset of pir genes, previously associated with increased virulence, were more highly expressed in PcCB, suggesting a role for this gene family in virulence differences between strains. We found that core genes involved in red blood cell invasion have been under positive selection and that the more virulent strain has a greater preference for reticulocytes, which has elsewhere been associated with increased virulence. Conclusions: These results provide the basis for a mechanistic understanding of the phenotypic differences between Plasmodium chabaudi strains, which might ultimately be translated into a better understanding of malaria parasites affecting humans

Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern [version 1; referees: 2 approved]

Background: Malaria parasite species differ greatly in the harm they do to humans. While P. falciparum kills hundreds of thousands per year, P. vivax kills much less often and P. malariae is relatively benign. Strains of the rodent malaria parasite Plasmodium chabaudi show phenotypic variation in virulence during infections of laboratory mice. This make it an excellent species to study genes which may be responsible for this trait. By understanding the mechanisms which underlie differences in virulence we can learn how parasites adapt to their hosts and how we might prevent disease. Methods: Here we present a complete reference genome sequence for a more virulent P. chabaudi strain, PcCB, and perform a detailed comparison with the genome of the less virulent PcAS strain. Results: We found the greatest variation in the subtelomeric regions, in particular amongst the sequences of the pir gene family, which has been associated with virulence and establishment of chronic infection. However, despite substantial variation at the sequence level, the repertoire of these genes has been largely maintained, highlighting the requirement for functional conservation as well as diversification in host-parasite interactions. However, a subset of pir genes, previously associated with increased virulence, were more highly expressed in PcCB, suggesting a role for this gene family in virulence differences between strains. We found that core genes involved in red blood cell invasion have been under positive selection and that the more virulent strain has a greater preference for reticulocytes, which has elsewhere been associated with increased virulence. Conclusions: These results provide the basis for a mechanistic understanding of the phenotypic differences between Plasmodium chabaudi strains, which might ultimately be translated into a better understanding of malaria parasites affecting humans