Iterative optimization-based simulation: a decision support tool for job release

“This is a post-peer-review, pre-copyedit version of an article published in Advances in Intelligent Systems and Computing. The final authenticated version is available online at: 10.1007/978-3-319-77712-2_66 "Job release is an essential scheduling function and a core part of every production planning and control system. Essentially, job release has to do with the timing and the jobs to release on to the shop floor, in such way that, a balanced and restricted workload is achieved. In this paper, an Iterative Optimization-based Simulation (IOS) decision support tool is proposed for job release. This is in line with Industry 4.0 paradigm, allowing the autonomous selection of jobs based on the current shop floor situation. This decision support tool is implemented using SIMIO as a simulation manager, MATLAB as an optimization manager and MySQL as a database manager.info:eu-repo/semantics/publishedVersio

Antinociceptive effect of palm date spathe hydroalcoholic extract on acute and chronic pain in mice as compared with analgesic effect of morphine and diclofenac

BACKGROUNDS: In Persian traditional medicine, palm date spathe (PDS) is introduced as an analgesic. Therefore, this study was designed to investigate the analgesic effect of hydroalcoholic extract of PDS on acute and chronic pain in mice in comparison with diclofenac and morphine. MATERIALS AND METHODS: In this study, which was conducted in summer 2014, 220 male mice (20-30 g) were randomly divided into two categories, each consists of 11 groups as follows: A normal control group, a solvent (Tween 80) control group, 3 morphine positive control groups (2, 4 and 8 mg/kg), 3 diclofenac positive control groups (10, 20 and 30 mg/kg), and 3 main experimental PDS groups (2, 20, and 200 mg/kg). Hot plate was applied on animals in one category and writing test on the other category to assess acute and chronic pain, respectively. RESULTS: In the writing test, the average writing time and number of animals receiving a maximum dosage of morphine, diclofenac, and PDS were significantly less than the control group. In the hot plate test, only groups receiving different doses of morphine at different time points and those received 30 mg/kg diclofenac at 15 min after the intervention showed significant difference with the control group. CONCLUSION: 200 mg/kg extract of PDS, revealed a significant analgesic effect on chronic pain, but it did not show any analgesic effect on acute pain