43 research outputs found
Respiratory support withdrawal in intensive care units: families, physicians and nurses views on two hypothetical clinical scenarios
Biópsia de lesões pulmonares por agulha cortante guiada pela tomografia computadorizada
PURPOSE: To report the experience of a radiology department in the use of computed tomography - guided cutting needle biopsy of pulmonary nodules, by evaluating diagnostic yield and incidence of complications. METHODS: This is a retrospective analysis of 52 consecutive patients who underwent lung lesion biopsy guided by computed tomography, performed between May 1997 and May 2000. Thirty-five patients were male and 17 were female, with ages ranging from 5 to 85 years (median, 62 years). The size of the lesions ranged from 1.8 to 15 cm (median, 5.4 cm). RESULTS: In a total of 52 biopsies of lung lesions, 51 biopsies (98.1%) supplied appropriate material for histopathological diagnosis, with 9 diagnosed (17.3%) as benign and 42 (80.8%) as malignant lesions. Specific diagnosis was obtained in 44 (84.6%) biopsies: 4 benign (9.1%) and 40 (90.9%) malignant lesions. The sensitivity, specificity, and accuracy of the cutting needle biopsies for determining presence of malignancy were 96.8%, 100%, and 97.2%, respectively. Complications occurred in 9 cases (17.3%), including 6 cases (11.5%) of small pneumothorax, 1 (1.9%) of hemoptysis, 1 (1.9%) of pulmonary hematoma, and 1 (1.9%) of thoracic wall hematoma. All had spontaneous resolution. There were no complications requiring subsequent intervention. CONCLUSION: The high sensitivity and specificity of the method and the low rate of complications have established cutting needle biopsy as an efficient and safe tool for the diagnosis of lung lesions. In our hospital, cutting needle biopsy is considered a reliable procedure for the evaluation of indeterminate pulmonary nodules.OBJETIVO: Apresentar a experiência inicial de um serviço de radiologia, no uso de biópsia de lesões pulmonares por agulha cortante guiada por tomografia computadorizada, avaliando o valor diagnóstico e incidência de complicações. MÉTODOS: Realizamos análise retrospectiva de 52 pacientes submetidos à biópsia de lesão pulmonar guiada pela tomografia computadorizada. Analisamos o perÃodo de maio de 1997 até maio de 2000. Trinta e cinco pacientes eram de sexo masculino e 17 feminino, com idade variando de cinco a 85 anos (mediana de 62 anos). O tamanho das lesões pulmonares variou de 1,8 a 15 cm (mediana de 5,4 cm). RESULTADOS: Entre os 52 casos, 51 (98,1%) forneceram material adequado para diagnóstico histopatológico, com nove diagnósticos (17,3%) de lesão benigna e 42 (80,8%) de lesão maligna. Quarenta e quatro (84,6%) obtiveram diagnósticos especÃficos a partir de análise histopatológica, sendo quatro benignos e 40 malignos. A sensibilidade, a especificidade e a acurácia do método para lesões malignas foi de 96,8%, 100% e 97,2%, respectivamente. Nove casos (17,3%) de complicações ocorreram, sendo seis casos (11,5%) de pneumotórax pequeno, um (1,9%) de hemoptise, um (1,9%) de hematoma intrapulmonar e um outro caso (1,9%) de hematoma na parede torácica. Não houve complicação que necessitasse de intervenção posterior. CONCLUSÃO: As altas sensibilidade e especificidade, e o baixo Ãndice de complicações tornam o método de biópsia por agulhas cortantes uma ferramenta eficiente e segura para diagnóstico de lesões pulmonares. Em nosso hospital é considerado um procedimento confiável para a avaliação de nódulos pulmonares indeterminados
Biópsia de massas mediastinais guiadas por tomografia computadorizada: agulhas finas versus cortantes
PURPOSE: To report the experience of a radiology department in the use of computed tomography guided biopsies of mediastinal lesions with fine and cutting needles, describing the differences between them. The results of adequacy of the sample and histologic diagnoses are presented according to the type of needle used. METHODS: We present a retrospective study of mediastinal biopsies guided by computed tomography performed from January 1993 to December 1999. Eighty-six patients underwent mediastinal biopsy in this period, 37 with cutting needles, 38 with fine needles, and 11 with both types (total of 97 biopsies). RESULTS: In most cases, it was possible to obtain an adequate sample (82.5%) and specific diagnosis (67.0%). Cutting-needle biopsy produced a higher percentage of adequate samples (89.6% versus 75.5%, P = 0.068) and of specific diagnosis (81.3% versus 53.1%, P = 0.003) than fine-needle biopsy. There were no complications that required intervention in either group. CONCLUSION: Because they are practical, safe, and can provide accurate diagnoses, image-guided biopsies should be considered the procedure of choice in the initial exploration of patients with mediastinal masses. In our experience, cutting needles gave higher quality samples and diagnostic rates. We recommend the use of cutting needles as the preferred procedure.OBJETIVO: Apresentar a experiência de um serviço de radiologia na prática de punções biópsias de massas mediastinais guiadas por tomografia computadorizada com agulhas finas ou cortantes, descrevendo as diferenças entre elas. Os resultados referentes a material suficiente e diagnóstico histológico são apresentados de acordo com o tipo de agulha utilizado. MÉTODOS: Apresentamos um estudo retrospectivo de biópsias mediastinais guiadas por tomografia computadorizada realizadas em nosso hospital no perÃodo de janeiro de 1993 a dezembro de 1999. Oitenta e seis pacientes foram submetidos a biópsia mediastinal neste perÃodo, sendo 37 realizadas com agulhas cortantes, 38 com agulhas finas e 11 com ambas, (total de 97 biópsias). RESULTADOS: Na maioria dos casos foi possÃvel se obter material adequado (82.5% ) e diagnóstico especÃfico (67 %). As agulhas cortantes apresentaram maior porcentagem de material suficiente (89.6% versus 75,5%, P=0,068) e de diagnóstico especÃfico (81,3% versus 53,1%, p=0,003 ) do que as agulhas finas. Não houveram complicações que requisessem intervenção em nenhum dos grupos. CONCLUSÃO: Pela praticidade, segurança e grande probabilidade de diagnóstico acurado sem procedimentos mais invasivos, as biópsias guiadas por imagem devem ser consideradas como a primeira etapa na investigação de massas mediastinais. Pela nossa experiência as agulhas cortantes fornecem material de maior qualidade e maior taxa de diagnóstico. Nós recomendamos o uso das agulhas cortantes como procedimento preferencial
Carcinoma de pulmão não pequena células: validação do sistema de estadiamento em uma única instituição (1990-200)
OBJECTIVE: To analyze surgical and pathological parameters and outcome and prognostic factors of patients with nonsmall cell lung cancer (NSCLC) who were admitted to a single institution, as well as to correlate these findings to the current staging system. METHOD: Seven hundred and thirty seven patients were diagnosed with NSCLC and admitted to Hospital do Cancer A. C. Camargo from 1990 to 2000. All patients were included in a continuous prospective database, and their data was analyzed. Following staging, a multidisciplinary team decision on adequate management was established. Variables included in this analysis were age, gender, histology, Karnofsky index, weight loss, clinical stage, surgical stage, chemotherapy, radiotherapy, and survival rates. RESULTS: 75.5% of patients were males. The distribution of histologic type was squamous cell carcinoma 51.8%, adenocarcinoma 43.1%, and undifferentiated large cell carcinoma 5.1%. Most patients (73%) presented significant weight loss and a Karnofsky index of 80%. Clinical staging was IA 3.8%, IB 9.2%, IIA 1.4%, IIB 8.1%, IIIA 20.9%, IIIB 22.4%, IV 30.9%. Complete tumor resection was performed in 24.6% of all patients. Surgical stage distribution was IA 25.3%, IB 1.4%, IIB 17.1%, IIIA 16.1%, IIIB 20.3%, IV 11.5%. Chemotherapy and radiotherapy were considered therapeutic options in 43% and 72%, respectively. The overall 5-year survival rate of nonsmall cell lung cancer patients in our study was 28%. Median survival was 18.9 months. CONCLUSIONS: Patients with NSCLC who were admitted to our institution presented with histopathologic and clinical characteristics that were similar to previously published series in cancer hospitals. The best prognosis was associated with complete tumor resection with lymph node dissection, which is only achievable in earlier clinical stages.OBJETIVO: Analisar o resultado e fatores prognósticos de patients com CPNPC admitidos em uma única instituição e correlacionar os dados com o sistema atual de estadiamento. MÉTODO: Setecentos e trinta e sete pacientes com diagnóstico de CPNPC foram admitidos ao Hospital do Cancer A. C. Camargo entre 1990 e 2000. Todos os pacientes foram incluÃdos em um banco de dados contÃnuo prospectivo e seus dados foram analisados. Após o estadiamento, uma equipe multidisciplinar estabeleceu decisões sobre o manejo adequado para o caso. Variáveis analisadas incluÃram idade, sexo, tipo histológico, Ãndice de Karnofsky, perda de peso, estadio clÃnico, estadio cirúrgico, quimioterapia, radioterapia e taxa de sobrevida. RESULTADOS: 75,5% dos pacientes eram do sexo masculino. A distribuição dos tipos histológicos foi carcinoma espino celular 51,8%, adenocarcinoma 43,% e carcinoma indiferenciado de grandes células 5,1%. A maior parte apresentou perda de peso significativa e um Karnofsky Index de 80%. O estadiamento clÃnico foi IA 3,8%, IB 9,2%, IIA 1,4%, IIB 8,1%, IIIA 20,9%, IIIB 22,4%, IV 30,9%. A ressecção total do tumor foi possÃvel em 24,6% dos casos. A distribuição do estadiamento cirúrgico foi IA 25,3%, IB 1,4%, IIA 1,4%, IIB 17,1%, IIIA 16,1%, IIIB 20,3%, IV 11,5%. Quimioterapia e radioterapia também foram consideradas opções terapêuticas. A sobrevida global de 5 anos em nosso estudo foi de 28%, sendo a sobrevida mediana de18,9 meses. CONCLUSÕES: CPNPC é uma doença que requer atenção especial, devido aos altos Ãndices de morbi-mortalidade. Melhor prognóstico está associado à ressecção completa do tumor, com dissecção de linfonodos. Todavia, isso só é possÃvel em estadios clÃnicos mais precoces
O nÃvel de dependência da nicotina é um fator de risco independente para o câncer: um estudo caso-controle
BACKGROUND: Less than 20% of lifetime smokers will ever develop cancer. Smoking habits characteristics, particularly the level of nicotine dependence level, were not fully evaluated as a marker of risk. METHODS: Case-control study of voluntary patients prospectively enrolled in a smoking cessation program in a cancer hospital. For each cancer case, patients of the same age and sex were selected. The Beck Depression Inventory, an instrument for the diagnosis of depressive mood and clinical depression, and the Fagerström Test Questionnaire, a questionnaire that has a good correlation with nicotine levels, used to determine the degree of dependence on nicotine, were applied. Age on admission to the study, sex, and number of pack-years were also evaluated. RESULTS: From May 1999 to May 2002, 56 cancer patients (case) and 85 matching controls (control) were identified in the population studied. There was no difference regarding pack-years. Fagerström Test Questionnaire was significantly higher in patients with cancer (7.5 ± 1.9) compared to controls (6.3 ± 2.0). We found a Fagerström Test Questionnaire >; 7 in 73.2% of the cancer cases versus 43.5% of the controls (p=0.001). The proportion of depressed patients was higher in the cancer group (37.5% x 17.6%). Logistic regression adjusted for age and tobacco consumption disclosed that Fagerström Test Questionnaire score >; 7 has an odds ratio for cancer of 3.45 (95% CI 1.52 - 7.83, p = 0.003). CONCLUSION: Fagerström Test Questionnaire higher than 7 was identified as a risk factor for cancer in smokers with similar tobacco consumption.OBJETIVO: Menos de 20% dos fumantes crônicos desenvolverá cancer. As caracterÃsticas do hábito de fumar, particularmente o nÃvel de dependência à nicotina, não foram avaliadas inteiramente como um marcador do risco. MÉTODOS: Estudo caso-controle de pacientes voluntários, registrados prospectivamente em um programa de cessação de tabagismo em um hospital de cancer. Para cada caso de cancer, pacientes da mesma idade e sexo foram selecionados. O inventário de depressão de Beck, um instrumento validado para diagnóstico de estado depressivo e depressão clÃnica e o questionário de tolerância de Fagerstron , que é usado para determinar o grau de dependência e tem boa correlação com nÃveis de nicotina, foram aplicados. Idade na admissão ao estudo, sexo, número de maços-anos fumados foram avaliados também. RESULTADOS: De maio de 1999 a maio de 2002, 56 pacientes de câncer (caso) e 85 controles pareados (controle) foram identificados na população estudada . Não houve diferença quanto ao número de maços-ano. O questionário de tolerância de Fagerstron foi significativamente mais elevado nos pacientes com câncer (7.5 ± 1.9) comparado aos controles (6.3 ± 2.0). Encontramos um questionário de tolerância de Fagerstron >; 7 em 73.2% dos casos de câncer, contra 43.5% dos controles (p=0.001). A proporção de pacientes deprimidos foi mais elevada no grupo do cancer (37.5% x 17.6%). A regressão logÃstica, ajustada para a idade e o consumo do tabaco, apontou que uma contagem de questionário de tolerância de Fagerstron >; 7 tem uma razão de chance para câncer de 3.45 (CI 95% 1.52 - 7.83, p = 0.003). CONCLUSÃO: Resultado no questionário de tolerância de Fagerstron maior que 7 foi identificado como um fator de risco para cancer em fumantes com consumo similar do tabaco
Trend of Maximal Inspiratory Pressure in Mechanically Ventilated Patients: Predictors
INTRODUCTION: It is known that mechanical ventilation and many of its features may affect the evolution of inspiratory muscle strength during ventilation. However, this evolution has not been described, nor have its predictors been studied. In addition, a probable parallel between inspiratory and limb muscle strength evolution has not been investigated. OBJECTIVE: To describe the variation over time of maximal inspiratory pressure during mechanical ventilation and its predictors. We also studied the possible relationship between the evolution of maximal inspiratory pressure and limb muscle strength. METHODS: A prospective observational study was performed in consecutive patients submitted to mechanical ventilation for > 72 hours. The maximal inspiratory pressure trend was evaluated by the linear regression of the daily maximal inspiratory pressure and a logistic regression analysis was used to look for independent maximal inspiratory pressure trend predictors. Limb muscle strength was evaluated using the Medical Research Council score. RESULTS: One hundred and sixteen patients were studied, forty-four of whom (37.9%) presented a decrease in maximal inspiratory pressure over time. The members of the group in which maximal inspiratory pressure decreased underwent deeper sedation, spent less time in pressure support ventilation and were extubated less frequently. The only independent predictor of the maximal inspiratory pressure trend was the level of sedation (OR=1.55, 95% CI 1.003 - 2.408; p = 0.049). There was no relationship between the maximal inspiratory pressure trend and limb muscle strength. CONCLUSIONS: Around forty percent of the mechanically ventilated patients had a decreased maximal inspiratory pressure during mechanical ventilation, which was independently associated with deeper levels of sedation. There was no relationship between the evolution of maximal inspiratory pressure and the muscular strength of the limb