Optimization of surface-mount-device light-emitting diode packaging : investigation of effects of component optical properties on light extraction efficiency

An investigation of the effects of the optical properties of surface-mount-device (SMD) light-emitting diode (LED) (side-view and top-view LEDs) packaging (PKG) components on the light extraction efficiency ηPKG using ray-tracing simulations is presented. In particular, it is found that the optical properties of the PKG resin and the lead-frame (L/F) silver-plating significantly affect ηPKG. Thus, the effects of the surface reflection methods of these components are investigated in order to optimize the optical design of the LED PKG. It is shown that there exists peak extraction efficiency for each PKG, and the cavity angle formed by the cavity wall is important to the optical design. In addition, the effect of phosphor present in the mold resin is examined using a Mie scattering simulation. Finally, an SMD LED PKG optical design method is proposed on the basis of the simulation results

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer’s Disease by Peptidome Technology

Background: Because dementia is an emerging problem in the world, biochemical markers of cerebrospinal fluid (CSF) and radio-isotopic analyses are helpful for diagnosing Alzheimer’s disease (AD). Although blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid- β (Aβ), plasma tau, and serum antibodies for Aβ1 - 42 are not yet well established. Objective: We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology. Methods: With only 1.5μl of serum, we examined a new target plate “BLOTCHIP®” plus a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) to discriminate control (n = 100), MCI (n = 60), and AD (n = 99). In some subjects, cognitive Mini-Mental State Examination (MMSE) were compared to positron emission tomography (PET) with Pittsburgh compound B (PiB) and the serum probability of dementia (SPD). The mother proteins of candidate serum peptides were examined in autopsied AD brains. Results: Apart from Aβ or tau, the present study discovered a new diagnostic 4-peptides-set biomarker for discriminating control, MCI, and AD with 87% of sensitivity and 65% of specificity between control and AD (***p  Conclusion: The present serum biomarker set provides a new, rapid, non-invasive, highly quantitative and low-cost clinical application for dementia screening, and also suggests an alternative pathomechanism of AD for neuroinflammation and neurovascular unit damage

The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18 medical institutions in our prefecture and were diagnosed with LSS-associated intermittent claudication. A second survey was performed after a parts per thousand yen6 weeks for 79 of the subjects to evaluate therapy with limaprost (an oral prostaglandin E1 derivative) or etodolac (an NSAID). Symptoms, maximum walking time, QOL, ADL items, and relationships among these variables were investigated for all 91 patients. Leg pain, leg numbness, and low back pain while walking were surveyed by use of VAS scores (0-100). Leg pain, leg numbness, and low back pain while walking (VAS a parts per thousand yen25) were present in 83.5, 62.6, and 54.9 % of the patients in the first survey, and approximately half of the patients had a maximum walking time 30 min, showing that maximum walking time affected health-related QOL. Of the 79 patients who completed the second survey, 56 had taken limaprost and 23 (control group) had received etodolac. Limaprost improved possible walking time, reduced ADL interference, and significantly increased the EQ-5D utility score, whereas no significant changes occurred in the control group. Maximum walking time was prolonged by a parts per thousand yen10 min and the EQ-5D utility value was improved by a parts per thousand yen0.1 points in significantly more patients in the limaprost group than in the control group. According to the findings of this survey, at an average of 8 weeks after administration limaprost improved symptoms, QOL, and ADL in LSS patients whereas treatment with an NSAID reduced pain but did not have any other effects.ArticleJOURNAL OF ORTHOPAEDIC SCIENCE. 18(2):208-215 (2013)journal articl

プロセシング プラズマ ノ モニタリング ノ タメノ ゼツエン プローブホウ ノ ケンキュウ

京都大学0048新制・論文博士博士(工学)乙第11101号論工博第3706号新制||工||1259(附属図書館)UT51-2003-C671(主査)教授 橘 邦英, 教授 石川 順三, 教授 福山 淳学位規則第4条第2項該当Doctor of EngineeringKyoto UniversityDFA

A NEW FREQUENCY SELECTIVE WINDOW FOR CONSTRUCTING WAVEGUIDE BANDPASS FILTERS WITH MULTIPLE ATTENUATION POLES

Abstract—This paper presents a novel frequency selective window for waveguide filters. It has a resonant characteristic with two attenuation poles on both sides of a passband, that is, a dual-behavior resonance. Such frequency selective windows make it possible to construct a compact bandpass filter having multiple attenuation poles without any additional coupling structures. As design examples, we show 3-pole Chebyshev waveguide filters with six attenuation poles in both the microwave and the millimeter-wave regions. The validity of the present filters is proven by the comparison of the frequency characteristics between the calculated and the measured results. 1

High-performance horns with optimized waving taper

We demonstrate here two types of high-performance horns with waving taper. These horns show a high efficiency and a compact low cross polarization. Our design method is based on the optimization technique, and we discuss the designed and fabricated horn antennas in X-band numerically and experimentally

Circular-coverage beam multimode horn

This article presents a novel multimode horn for achieving high and uniform gain over a circular area. In order to design the taper configuration of the horn based on the optimization technique, we have evaluated mode coefficients for covering a circular area by means of universal patterns with maximum gain in arbitrary direction. Experimental investigation is performed for a test antenna fabricated in the X-band