Study and optimization of freeze-drying cycles of a model probiotic strain

[EN] This work is based on the experimental study of the freeze-drying process to understand the impact of numerous factors on the survival rates of a model probiotic strain of Lactobacillus casei type. With the aim to find out if cell density in the matrix and survival rates are linked, we have studied the location of the cells after freeze drying inside a porous matrix composed of a lactose basis with a polymer, the polyvinylpyrrolidone (PVP) in various amounts. The best survival rate were obtained at slow freezing rate for a formulation containing 5% (m/V) of lactose and 5% (m/V) of PVP.Verlhac, P.; Vessot-Crastes, S.; Degobert, G.; Cogné, C.; Andrieu, J.; Beney, L.; Gervais, P. (2018). Study and optimization of freeze-drying cycles of a model probiotic strain. En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 635-642. https://doi.org/10.4995/IDS2018.2018.7400OCS63564

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International audienceParticulate systems are various size, shapes and morphologies (nano- microparticles, liposomes, core-shell..). The development of these particulate systems is becoming increasingly important as a result of diverse industrial applications. The poor stability in aqueous medium of these systems constitutes a real obstacle to their commercialization. In this context, freeze drying is considered as the most convenient process to improve their long term stability. In this presentation, one will discuss the most important parameters that influence the success of freeze-drying of particulate systems and provides an overview of freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability

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How to encourage young people to take up a career in aerosol industry ?

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Hydroxypropyl methylcellulose hard capsules: An alternative to gelatin

International audienceHydroxypropyl methylcellulose (HPMC) capsules are currently an alternative to hard gelatin capsules, the most commonly used capsules until the present. The pharmacotechnical properties of these capsules are briefly presented and discussed. Their adhesive properties to the aesophageal mucosa, particularly important in oral administration, were the object of a comparative in vitro study which measured adhesive force and work when these capsules were placed in contact with porcine aesophageal mucosa. This work showed that hard capsule adhesive properties are high in comparison to those of other galenic forms. Nevertheless, under the experimental conditions used, it appeared that the adhesive properties of HPMC hard capsules are relatively comparable to those of gelatin capsules

Hydroxypropyl methylcellulose hard capsules: An alternative to gelatin

International audienceHydroxypropyl methylcellulose (HPMC) capsules are currently an alternative to hard gelatin capsules, the most commonly used capsules until the present. The pharmacotechnical properties of these capsules are briefly presented and discussed. Their adhesive properties to the aesophageal mucosa, particularly important in oral administration, were the object of a comparative in vitro study which measured adhesive force and work when these capsules were placed in contact with porcine aesophageal mucosa. This work showed that hard capsule adhesive properties are high in comparison to those of other galenic forms. Nevertheless, under the experimental conditions used, it appeared that the adhesive properties of HPMC hard capsules are relatively comparable to those of gelatin capsules

Loading and in vitro release of salbutamol from degradable cross-linked starch microspheres intended for pulmonary administration

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La lyophilisation (revalidation périodique du maintien de la stérilité d'un lyophilisateur dans un service de mise sous forme pharmaceutique)

LYON1-BU Santé (693882101) / SudocSudocFranceF