Increasing Positive Perceptions of Food Irradiation: Appealing to One\u27s Affective Domain

A study tested the effectiveness of experiential learning techniques in food irradiation technology to positively influence understanding in both the affective and cognitive domain. Research shows that food irradiation is a safe food technology effective at reducing foodborne illness, but the adoption rate of the technology remains slow. The short course employed experiential components, such as tours of food irradiation facilities, group activities, and taste-tests of irradiated produce. Data were collected assessing participants\u27 knowledge and perceptions about food irradiation, using Likert-type scales. The short course produced significant gains in participants\u27 knowledge and positively influenced participants\u27 perceptions of food irradiation issues

Electrochemical oxidation of CO on Cu single crystals under alkaline conditions

We perform a joint experimental-theoretical study of the electrochemical oxidation of CO on copper (Cu) under alkaline conditions. Using cyclic voltammetry on Cu single crystal surfaces, we demonstrate that both Cu terraces and steps show CO oxidation activity at potentials just slightly positive (0.03-0.14 V) of the thermodynamic equilibrium potential. The overpotentials are 0.23-0.12 V lower than that of gold (approx. 0.26 V), which up until now has been considered to be the most active catalyst for this process. Our theoretical calculations suggest that Cu's activity arises from the advantageous combination of simultaneous *OH adsorption under CO oxidation potentials and surmountable *CO-*OH coupling barriers. Experimentally observed onset potentials are in agreement with the computed onsets of *OH adsorption. We furthermore show that the onsets of *OH adsorption on steps are more affected by *CO-*OH interactions than on terraces due to a stronger competitive adsorption. Overall, Cu(100) shows the lowest overpotential (0.03 V) of the facets considered.Comment: 16 pages, 3 figures plus supplementary informatio

Micro- and Nanofabrication of Robust Reactive Arrays Based on the Covalent Coupling of Dendrimers to Activated Monolayers

We report on methods to fabricate robust micro- and nanopatterned platforms, comprising high functional group densities and quasi three-dimensional structures, for possible applications in biochip array technologies. For this purpose, amine-terminated poly(amidoamine) (PAMAM) dendrimers were immobilized via amide linkage formation on 11,11'-dithiobis(N-hydroxysuccinimidylundecanoate) (NHS-C10) self-assembled monolayers (SAMs) on gold surfaces. The coupling reaction and the resulting assemblies were characterized by grazing incidence reflection Fourier transform infrared spectroscopy, contact angle measurements, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy; the obtained surface coverage values were successfully fitted with a Langmuir isotherm. The fraction of unreacted peripheral primary amine groups of the surface-immobilized PAMAM dendrimers was 28% as determined by XPS analysis of trifluoroacetic anhydride-labeled assemblies. Patterning of the PAMAM dendrimers on NHS-C10 SAMs on the micrometer and sub-100-nm scale was achieved by microcontact printing and dip pen nanolithography. The resulting patterns are characterized by their high degree of order and stability of the transferred molecules due to covalent attachment

Голодомор 1932 –– 1933 рр. в Україні як геноцид

Given its fundamental role in development and cancer, the Wnt-beta-catenin signaling pathway is tightly controlled at multiple levels. RING finger protein 43 (RNF43) is an E3 ubiquitin ligase originally found in stem cells and proposed to inhibit Wnt signaling by interacting with the Wnt receptors of the Frizzled family. We detected endogenous RNF43 in the nucleus of human intestinal crypt and colon cancer cells. We found that RNF43 physically interacted with T cell factor 4 (TCF4) in cells and tethered TCF4 to the nuclear membrane, thus silencing TCF4 transcriptional activity even in the presence of constitutively active mutants of beta-catenin. This inhibitory mechanism was disrupted by the expression of RNF43 bearing mutations found in human gastrointestinal tumors, and transactivation of the Wnt pathway was observed in various cells and in Xenopus embryos when the RING domain of RNF43 was mutated. Our findings indicate that RNF43 inhibits the Wnt pathway downstream of oncogenic mutations that activate the pathway. Mimicking or enhancing this inhibitory activity of RNF43 may be useful to treat cancers arising from aberrant activation of the Wnt pathwa

Workshops of the Sixth International Brain–Computer Interface Meeting: brain–computer interfaces past, present, and future

Brain–computer interfaces (BCI) (also referred to as brain–machine interfaces; BMI) are, by definition, an interface between the human brain and a technological application. Brain activity for interpretation by the BCI can be acquired with either invasive or non-invasive methods. The key point is that the signals that are interpreted come directly from the brain, bypassing sensorimotor output channels that may or may not have impaired function. This paper provides a concise glimpse of the breadth of BCI research and development topics covered by the workshops of the 6th International Brain–Computer Interface Meeting

Turbulenzuntersuchungen im Reinraum. Auswirkungen auf die Umströmung sowie die Partikelausbreitung im Nachlauf von Bauteilen

Die strömungstechnische Auslegung von Reinen Räumen dient insbesondere dazu, das mit unerwünschten Partikeltransportvorgängen verbundene Auftreten von Quer- und Rückströmungen zu vermeiden. In Reinen Räumen mit turbulenzarmer Verdrängungsströmung versucht man aus diesem Grund, durch entsprechende bauliche Maßnahmen eine möglichst hohe Stabilität der Verdrängungströmung zu erreichen. Im nachfolgenden werden die Auswirkungen unterschiedlicher Strömungsverhältnisse im Reinraum auf die Umströmung sowie die Partikelausbreitung im Nachlauf von potentiellen Partikelquellen einander gegenübergestellt. Aus den gewonnenen Ergebnissen resultiert die Beurteilung der jeweiligen Strömungsbedingungen