Performance Analysis of Various Routing Protocols in 3D Body Architecture using Qualnet in WBSN

Wireless Body Sensor Network (WBSN) is a connectionless architecture used to monitor health of a patient or an athlete. Various routing strategies have been proposed to increase the network lifetime. In this work, we have compared some well known ad-hoc network routing protocols like DYMO, DSR, ZRP and LAR1 in WBSN. WBSN works in a small area like Bluetooth or Zigbee. Few gateway nodes are also considered to route the traffic. The simulations have been performed using Qualnet 6.1. Various parameters like jitter, throughput, end to end delay, packet delivery ratio has been used for comparison. Results revealed that ZRP have least end to end delay (0.2) and jitter (0.1), but have low throughput i.e. 2362 b/s as compared to DYMO and DSR i.e. 2752 b/s and 3026 b/s

Evolutionary Constraints Acting on DDX3X Protein Potentially Interferes with Rev-Mediated Nuclear Export of HIV-1 RNA

Differential host-pathogen interactions direct viral replication in infected cells. In HIV-1 infected cells, nuclear export of viral RNA transcripts into cellular cytoplasm is governed by interaction of HIV-1 Rev, Exportin-1 (CRM-1) and DDX3X. Knock down of DDX3X has been shown to drastically impair HIV replication. Here we show that evolutionary forces are responsible for demarking previously unidentified critical functionally important residues on the surface of DDX3X. Using computational approaches, we show that these functional residues, depending on their location, are capable of regulating ATPase and RNA helicase functions of DDX3X. The potential of these residues in designing better blockers against HIV-1 replication was also assessed. Also, using stepwise docking simulations, we could identify DDX3X-CRM-1 interface and its critical functional residues. Our data would help explain the role of DDX3X in HIV-1 Rev function with potential to design new intervention strategies against HIV-1 replication

Coherent bremsstrahlung and GDR width from 252Cf cold fission

The energy spectrum of the high energy gamma-rays in coincidence with the prompt gamma rays has been measured for the spontaneous fission of 252Cf. The nucleus-nucleus coherent bremsstrahlung of the accelerating fission fragments is observed and the result has been substantiated with a theoretical calculation based on the coulomb acceleration model. The width of the giant dipole resonance (GDR) decay from the excited fission fragments has been extracted for the first time and compared with the thermal shape fluctuation model (TSFM) in the liquid drop formalism. The extracted GDR width is significantly smaller than the predictions of TSFM.Comment: 12 pages, 3 figures, accepted for publication in Phys. Lett.

Thyroid: Functional Food (Family Welfare, Family Physician, Nurse, Computational Validation, and Drug Discovery)

Goiter needs nursing. It is thyroid gland hypertrophy, important organ of endocrine system produces hormones for metabolism, poly organ normal function including blood chemistry, hemodynamics & erythropoiesis. Arising out of  Iodine deficiency and or life style, jointly or severally. Rarely cancer. Hypothalamus signals pituitary gland to produce thyroid-stimulating hormone (TSH), which regulates hormone production. TSH uptake and\or efficient conversion is the pathophysiology. Current standard medication for such pathophysiology  being long period ‘hormone replacement therapy’ (HRT). No prophylaxis; no synergic medicaments; no functional food. There are several natural sources (a) Star Anise -Illicium Verumtree (b) Cinnamon Bark - Cinnamon verum\cassia (c) Fruit & flower of  Myristica  fragrans are rich in (i) caffeic (ii) cinnamic acids; no conflicting and or confounding co-moieties; have abundant availability; historical (non-goiter specific) home use worldwide & non-toxic. Study indicates the theoretical-computational interaction of TSH with compound (i) & (ii). RESULT :   Binding affinity is of the order -5 kcal/Mol for either with a minimum of 4 ‘H’ bonds at ~ 2 Å distance and a stable-high ‘inhibition constant’ of   >180µm. Thus, compound (i) & (ii) present likeness, compatibility with TSH as Drug Discovery candidates at molecular level and also as ‘synergic’ with TSH.  Medicinal plant products  ‘A-B-C’ posits the immediate possibility of use as ‘Functional Foods’ targeting TSH uptake and\or efficient conversion. Goiter is chronic and is treated as  out-patient malady.  Caffeic & cinnamic acids rich functional foods are (A) prophylactic  (B) effective tools in the hands of the nurses. Paradigm shift in concept. &nbsp

MoS 2 ‐Polyaniline Based Flexible Electrochemical Biosensor: Toward pH Monitoring in Human Sweat

Abstract Wearable pH sensors for sweat analysis have garnered significant scientific attention for the detection of early signs of many physiological diseases. In this study, a MoS2‐polyaniline (PANI) modified screen‐printed carbon electrode (SPCE) is fabricated and used as a sweat biosensor. The exfoliated MoS2 nanosheets are drop casted over an SPCE and are functionalized by a conducting polymer, polyaniline (PANI) via the electropolymerization technique. The as‐fabricated biosensor exhibits high super‐Nernstian sensitivity of −70.4 ± 1.7 mV pH−1 in the linear range of pH 4 to 8 of 0.1 m standard phosphate buffer solution (PBS), with outstanding reproducibility. The sensor exhibits excellent selectivity against the common sweat ions including Na+, Cl−, K+, and NH4+ with tremendous long‐term stability over 180 min from pH 4 to 6. The enhanced active surface area and better electrical conductivity as a consequence of the synergistic effect between MoS2 and PANI are correlated with the boosted performance of the as‐produced biosensor. The feasibility of the sensor is further examined using an artificial sweat specimen and the successful detection confirms the potential of the biosensor for a real‐time noninvasive, skin attachable, and flexible wearable pH sensor

Sun Stroke: Physiological Mechanism and Palliative Intervention

Sun stroke the high emergency clinical condition is a cascade of six prominent symptom groups with failed gravity & intramuscular routes; gut constriction; grave prognosis. 2%KCL+5% NaCl +2% CaOH with diluted milk as vector is proposed.  Institutional framework is absent. Nurses are called upon

Fabrication of Gold Nanoparticles Embedded Laser-Induced Graphene (LIG) Electrode for Hydrogen Evolution Reaction

The advancement of renewable energy technologies like water electrolysis and hydrogen fuel cells relies on the fabrication of effective and reliable catalysts for the hydrogen evolution process (HER). In this regard, we report gold nanoparticles embedded in laser-induced graphene electrodes for regulation of overpotential and electrocatalytic performance of hydrogen evolution reaction. Gold nanoparticles were deposited onto the LIG surface using electrode deposition via cyclic voltammetry (CV) at different cycle lengths. The catalyst fabrication technique enables the manipulation of many electrochemical parameters, such as overpotential value, charge transfer resistance, electrochemical active surface area, and tafel slope, through the adjustment of cyclic voltammetry (CV) cycles. The LIG-Au@50 sample demonstrates remarkable electrocatalytic characteristics, as evidenced by its low overpotential of 141 mV at a current density of 10 mA/cm2 and reduced tafel slope of 131 mV/decade in an acidic environment. Furthermore, the presence of an augmented electrochemical active surface area, a mass activity of 8.80 A/g, and a high turnover frequency of 0.0091 s−1 suggest elevated and significant accessibility to plentiful active sites. A significant decrease in charge transfer resistance resulted in an enhanced rate of the water-splitting reaction