Current pharmacological agents for the treatment of premature ejaculation

This study was aimed to review and assess the update studies regarding medical treatment for premature ejaculation (PE). It is the most common sexual problem affecting men. It can affect men at all ages and has a serious impact on the quality of life for men and their partners. A wide variety of therapeutic modalities have been tried for treatment of premature ejaculation. Psychological therapies may be helpful for patients with complaint PE. Several topical therapies have been used including lidocaine cream, lidocaine-prilocaine cream. There has been recent interest in the selective serotonin reuptake inhibitors (SSRI) for the treatment of PE, due to the fact that one of their common side effects is delayed ejaculation. Currently used SSRIs have several non-sexual side effects and long half lives, therefore there has been interest in developing a short acting, and efficacious SSRI that can be used on-demand for PE. Dapoxetine has been recently evaluated for the treatment of PE by several groups, and results so far appear promising

Next-gen traffic surveillance: AI-assisted mobile traffic violation detection system

Road traffic accidents pose a significant global public health concern, leading to injuries, fatalities, and vehicle damage. Approximately 1,3 million people lose their lives daily due to traffic accidents [World Health Organization, 2022]. Addressing this issue requires accurate traffic law violation detection systems to ensure adherence to regulations. The integration of Artificial Intelligence algorithms, leveraging machine learning and computer vision, has facilitated the development of precise traffic rule enforcement. This paper illustrates how computer vision and machine learning enable the creation of robust algorithms for detecting various traffic violations. Our model, capable of identifying six common traffic infractions, detects red light violations, illegal use of breakdown lanes, violations of vehicle following distance, breaches of marked crosswalk laws, illegal parking, and parking on marked crosswalks. Utilizing online traffic footage and a self-mounted on-dash camera, we apply the YOLOv5 algorithm's detection module to identify traffic agents such as cars, pedestrians, and traffic signs, and the strongSORT algorithm for continuous interframe tracking. Six discrete algorithms analyze agents' behavior and trajectory to detect violations. Subsequently, an Identification Module extracts vehicle ID information, such as the license plate, to generate violation notices sent to relevant authorities

Alloyed Heterostructures of CdSexS1-x Nanoplatelets with Highly Tunable Optical Gain Performance

Here, we designed and synthesized alloyed heterostructures of CdSexS1-x nanoplatelets (NPLs) using CdS coating in the lateral and vertical directions for the achievement of highly tunable optical gain performance. By using homogeneously alloyed CdSexS1-x core NPLs as a seed, we prepared CdSexS1-x/CdS core/crown NPLs, where CdS crown region is extended only in the lateral direction. With the sidewall passivation around inner CdSexS1-x cores) we achieved enhanced photoluminescence quantum yield (PL-QY) (reaching 60%), together-with increased absorption cross-section and improved stability without changing the emission Spectrum of CdSexS1-x, alloyed core NPLs. In addition, we further extended the spectral tunability of these solution-processed NPLs with the synthesis of CdSexS1-x/CdS core/shell NPLs. Depending on the sulfur composition of the CdSexS1-x, core and thickness of the CdS shell, CdSexS1-x/CdS core/shell NPLs possessed highly tunable emission characteristics within the spectral range of 560-650 nm. Finally, we studied the optical gain performances of different heterostructures of CdSexS1-x, alloyed NPLs offering great advantages, including reduced reabsorption and spectrally tunable optical gain range. Despite their decreased PL-QY and reduced absorption cross-section upon increasing the sulfur composition, CdSexS1-x based NPLs exhibit highly tunable amplified spontaneous emission performance together with low gain thresholds down to similar to 53 mu J/cm(2)

Influences of Toothbrushing and Different Toothpastes on the Surface Roughness and Color Stability of Interim Prosthodontic Materials.

The surface properties and color stability of interim crown materials may vary depending on the toothbrushing procedure. This study aimed to investigate the effects of toothbrushing and different toothpastes on the surface roughness (Ra) and color stability of different interim crown materials. Disc-shaped specimens were prepared from four interim crown materials (Tab 2000 (ChPM), Imident (LaPM), Protemp 4 (ChDM), and Telio-CAD (CadPM)). Specimens were divided into four subgroups for the control group (Cnt) and for simulated toothbrushing with distilled water (Dw) or with two different toothpastes (whitening toothpaste (WTp), activated charcoal toothpaste (ACTp)). The specimens' Ra values were measured before and after 10,000 cycles of toothbrushing. The color parameters were measured and the color differences (ΔE00) were calculated. Data were statistically analyzed by two-way analysis of variance (ANOVA) and Tukey's HSD tests. A significant increase in the Ra values was observed after toothbrushing, except for the LaPM_Dw, ChDM_Dw, and all the CadPM specimens (p < 0.05). Toothbrushing with toothpastes increased the ΔE00 values of all ChPM and ChDM interim materials (p < 0.05). Before and after all toothbrushing procedures, the CadPM specimens had smoother and ChPM specimens had rougher surfaces than the other interim materials. The two tested toothpastes had similar effects on the Ra of all interim materials. Non-perceivable color changes were seen only with the CadPM_Dw group

Holmium: yttrium-aluminum-garnet (Ho:YAG) laser for resection of bladder tumor in a pediatric patient

Bladder tumours are rare in children, with only 0.4% of cases occurring in the first 2 decades of life. Herein, a pediatric patient who underwent TUR-B with a holmium: yttrium-aluminum-garnet (Ho:YAG) laser is presented. Its histopathology was reported as urothelial papilloma

Clinical Outcomes of Penile Prosthesis Implantation Surgery

Objective: We aimed to evaluating the outcomes of in­flatable penile prosthesis implantations and partner sat­isfaction. Methods: Data of 52 patients who underwent penile prosthesis implantation in single center between May 2010 and December 2015 were retrospectively analyzed. Types of prosthesis, complication and satisfaction rates of patients were recorded by EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction) questionnaire was used. Results: The mean age was 49.2±14.7 years for patients. The mean follow-up durations for 34.3±12.5 months. The mean hospital stay was 3.84±1.52 days. Evaluating of the couples satisfaction revealed that 44 (84%) of the patient were very satisfied. There was not any complication and no patient need to underwent revision surgery. Conclusion: Inflatable penile prosthesis implants, with high levels of treatment success, patient and partner sat­isfaction, are effective and safe options for treatment of organic erectile dysfunction with acceptable complication and revision rates

Conservative treatments for overactive bladder

Tüm kılavuzlarda, aşırı aktif mesane hastalığının ilk basamak tedavisinde konservatif yöntemler önerilmektedir. Bu makalede aşırı aktif mesane tedavisinde konservatif tedavilerin yeri ve etkinliği literatür bilgileri ışığında değerlendirilmiştir.Conservative treatments are recommended as the first line for the treatment of overactive bladder. In this paper, we reviewed the conservative treatments of overactive bladder on the light of literatur