79 research outputs found
Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study
Objectives/methods: This 1-yr prospective phase II trial evaluated the efficacy of deferasirox in regularly transfused patients aged 3-81 yrs with myelodysplastic syndromes (MDS; n = 47), Diamond-Blackfan anaemia (DBA; n = 30), other rare anaemias (n = 22) or beta-thalassaemia (n = 85). Dosage was determined by baseline liver iron concentration (LIC). Results: In patients with baseline LIC >= 7 mg Fe/g dry weight, deferasirox initiated at 20 or 30 mg/kg/d produced statistically significant decreases in LIC (P < 0.001); these decreases were greatest in MDS and least in DBA. As chelation efficiency and iron excretion did not differ significantly between disease groups, the differences in LIC changes are consistent with mean transfusional iron intake (least in MDS: 0.28 +/- 0.14 mg/kg/d; greatest in DBA: 0.4 +/- 0.11 mg/kg/d). Overall, LIC changes were dependent on dose (P < 0.001) and transfusional iron intake (P < 0.01), but not statistically different between disease groups. Changes in serum ferritin and LIC were correlated irrespective of disease group (r = 0.59), supporting the potential use of serum ferritin for monitoring deferasirox therapy. Deferasirox had a safety profile compatible with long-term use. There were no disease-specific safety/tolerability effects: the most common adverse events were gastrointestinal disturbances, skin rash and non-progressive serum creatinine increases. Conclusions: Deferasirox is effective for reducing iron burden with a defined, clinically manageable safety profile in patients with various transfusion-dependent anaemias. There were no disease-specific adverse events. Once differences in transfusional iron intake are accounted for, dose-dependent changes in LIC or serum ferritin are similar in MDS and other disease groups
Biennale de l'Association européenne des études américaines, Bordeaux, 22-25 mars 2002
Debusscher Gilbert. Biennale de l'Association européenne des études américaines, Bordeaux, 22-25 mars 2002. In: Bulletin de la Classe des lettres et des sciences morales et politiques, tome 14, n°1-6, 2003. pp. 277-279
Le 11e festival de littérature Tenessee Williams à la Nouvelle Orléans, 20-23 mars 1997
Debusscher Gilbert. Le 11e festival de littérature Tenessee Williams à la Nouvelle Orléans, 20-23 mars 1997. In: Bulletin de la Classe des lettres et des sciences morales et politiques, tome 8, n°7-12, 1997. pp. 559-562
Pratique de l'anglais contemporain II
5e édition 1993-1994/1Documents destinés aux étudiants de seconde candidature en Journalisme et Communicationinfo:eu-repo/semantics/published
English Poetry from the Beginning to the Romantic Period
SYL-2543 = fascicule 1 ;SYL-2544 = fascicule 2Fascicule 2 :finEdition 1977-1978Fascicule 2 n'a pas été exécutée par les Presses Universitaires de Bruxelles1e et 2e candi. Philo. Germ.info:eu-repo/semantics/publishe
History of English Literature II: Historical Survey of English Poetry
SYL-060 = Volume I ;SYL-061 = Volume IIVolume I :English Poetry :From Antiquity to the End of the Romantic Period1re Ă©dition 1992-1993/12e candid. germ. langues et linguistiqueinfo:eu-repo/semantics/published
Conférence biennale de EAAS (European Association of American Studies), à Prague du 2 au 5 avril 2004
Debusscher Gilbert. Conférence biennale de EAAS (European Association of American Studies), à Prague du 2 au 5 avril 2004. In: Bulletin de la Classe des lettres et des sciences morales et politiques, tome 15, n°7-12, 2004. pp. 497-499
Pratique de l'anglais contemporain I
INFJOU1, INFLIV - GERM004info:eu-repo/semantics/published1
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