Additional file 1: of TOPPITS: Trial Of Proton Pump Inhibitors in Throat Symptoms. Study protocol for a randomised controlled trial

presents the CONSORT 2010 checklist of information to include when reporting a randomised trial, completed for TOPPITS. (PDF 43 kb

Additional file 2: of TOPPITS: Trial Of Proton Pump Inhibitors in Throat Symptoms. Study protocol for a randomised controlled trial

presents the SPIRIT 2013 Checklist—recommended items to address in a clinical trial protocol and related documents completed for TOPPITS. (PDF 35 kb

Additional file 1: Table S1. of Prevalence and socio-demographic correlates of cooking skills in UK adults: cross-sectional analysis of data from the UK National Diet and Nutrition Survey

Confidence of main food provider in using eight cooking techniques, National Diet & Nutrition Survey, 2008–09, n = 490. Table S2. Odds of main food provider having confidence in using eight cooking techniques, National Diet & Nutrition Survey, 2008–09, n = 490. Table S3. Confidence of main food in cooking 10 foods, National Diet & Nutrition Survey, 2008–09, n = 490. Table S4. Odds of main food provider having confidence in cooking 10 foods, National Diet & Nutrition Survey, 2008–09, n = 490. Table S5. Ability of main food provider to prepare four dish types without help, National Diet & Nutrition Survey, 2008–09, n = 490. (DOC 110 kb

Cover & Contents

SPIRIT figure showing schedule of events in cohort 2 of the trial. (PDF 180 kb

Additional file 5: of Tropomyosin Receptor Antagonism in Cylindromatosis (TRAC), an early phase trial of a topical tropomyosin kinase inhibitor as a treatment for inherited CYLD defective skin tumours: study protocol for a randomised controlled trial

SPIRIT figure showing schedule of events in cohort 1 of the trial. (PDF 140 kb

Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial

   Objective Analyse the impact of modern glucose-monitoring strategies on glycemic and patient-related outcomes in individuals with type 2 diabetes (T2D) and recent myocardial infarction (MI), and also assess cost effectiveness.  Research design and methods LIBERATES was a multicentre, two-arm randomised trial comparing self-monitoring of blood glucose (SMBG) with intermittently scanned continuous glucose monitoring (isCGM), also known as flash CGM, in individuals with T2D and recent MI, treated with insulin and/or sulphonylurea prior to hospital admission.  The primary outcome measure was time in range (TIR; glucose 3.9-10 mmol/l)/day on days 76-90 post randomisation. Secondary and exploratory outcomes included time in hypoglycemia, hemoglobin (Hb)A1c, clinical outcome, quality of life (QoL) and cost effectiveness.  Results  Of 141 participants aged [median 63 IQR (53, 70) years, 73% males] randomised, isCGM was associated with increased TIR by 17mins/day (95% credible interval -105, +153mins/day) with 59% probability for a benefit. Users of isCGM showed lower hypoglycemic exposure ( Combined glycemic emergencies/mortality occurred in 4 isCGM and 7 SMBG study participants. QoL measures marginally favoured isCGM and the intervention proved to be cost-effective.  Conclusions Compared with SMBG, isCGM in T2D individuals with MI marginally increases TIR and significantly reduces hypoglycemic exposure while equally improving HbA1c, explaining its cost-effectiveness. Studies are required to understand whether these glycemic differences translate into longer term clinical benefit. </p