Morphologically Directed Raman Spectroscopic Analysis of Forensic Samples

Morphologically directed Raman spectroscopy (MDRS) is a novel and reliable tool that would enable criminalists to obtain more discriminatory information from forensic samples than their current capabilities. MDRS combines automated particle imaging and Raman spectroscopy into one instrument. Particle imaging is performed to determine particle size and shape distributions of components in a blended sample. Particle size is an important physical property of particulate samples and can be used in conjunction with Raman spectroscopy in the analysis of a range of samples of forensic interest, including illicit and counterfeit drugs, soils, gunshot residue (GSR), and white powders. Although measurement of particle size distributions is routinely carried out across a wide range of industries and is often a critical parameter in the manufacture and analysis of many products and substances, it is not widely used in the forensic sciences. Raman spectroscopy is used in forensic science to determine the molecular chemistry of materials because it is rapid, reliable, allows for analysis without contacting the sample, is nondestructive, and enables detection at low concentrations. Combining these two analytical techniques into a single platform allows the individual components present within a blend or mixture to be independently characterized and compared

Mesomorphic silver(I) complexes of polycatenar 2 '- and 3 '-stilbazoles. Crystal and molecular structure of 3,4-dimethoxy-3 '-stilbazole and of two silver triflate complexes

The synthesis of 3,4-dialkoxy and 3,4,5-trialkoxy derivatives of 2- and 3-stilbazole are reported along with their related complexes with silver dodecylsulphate and silver triflate. The single crystal structures of one ligand and two complexes are reported. While none of the complexes of the 2-stilbazoles is liquid-crystalline, several complexes of the 3-stilbazoles show columnar mesophases as characterised by polarised optical microscopy and X-ray diffraction. The liquid crystal phase behaviour is compared with that of the parent 4-stilbazole derivatives

Preparation and single crystal structure of a dirhenium(I) complex of a bent-core mesogen

Dinuclear complexes of ReI are prepared by functionalising a symmetric, bent-core mesogen containing two imine groups. The resulting complex is characterised by single crystal X-ray diffraction and presents the expected geometry, but unfortunately the introduction of the two Re(CO)4 moieties suppresses the mesomorphism of the parent ligan

Mesomorphism of complexed 2,6-disubstituted pyridine ligands: crystal and molecular structure of two bent-core pyridines

Bent-core, polycatenar pyridines are reported, synthesized via a Siegrist coupling of di- and tri-alkoxybenzylidene fragments with 2,6-dimethylpyridine. None of these pyridines was liquid crystalline. Isomeric materials based on a 3,5-disubstituted pyridine core were mesomorphic in hydrogen-bonded complexes, whereas these new materials were not. However, the new pyridines did form mesomorphic metal complexes with silver salts. Some insight into this behaviour is gleaned from single crystal structure determinations of the model systems, 3,5-bis(3',4'-dimethoxystyryl) pyridine and 2,6-bis(3',4'-dimethoxystyryl) pyridine

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (<b>8</b>) and alisertib (MLN8237, <b>10</b>) have been identified as high affinity, selective, orally bioavailable inhibitors of Aurora A that have advanced into human clinical trials. Alisertib (<b>10</b>) is currently being evaluated in multiple Phase II and III clinical trials in hematological malignancies and solid tumors