567 research outputs found
Lipodystrophy as a late effect after stem cell transplantation
Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy following hematopoietic stem cell transplantation (HSCT) have been described. In this review, we summarize the cases described so far and discuss potential underlying mechanisms of the disease. The findings suggest that HSCT-associated lipodystrophies may be seen as a novel form of acquired lipodystrophy
Synchronization device for electrocardiography-gated echo-planar imaging
An electrocardiography (ECG) synchronization technique allowed triggering of 1.5-T echo-planar acquisitions of the heart, with high gradient slew rates. In 51 volunteers (37 men and 14 women, aged 21-48 years), the ECG signal was amplified, filtered, and converted into an optical signal directly above the heart and was transmitted optically outside the bore. Reliable and artifact-free ECG tracings were obtained in all cases, regardless of the gradient switching speed
A planar multipole ion trap
We report on the realisation of a chip-based multipole ion trap manufactured
using micro-electromechanical systems (MEMS) technology. It provides ion
confinement in an almost field-free volume between two planes of radiofrequency
electrodes, deposited on glass substrates, which allows for optical access to
the trap. An analytical model of the effective trapping potential is presented
and compared with numerical calculations. Stable trapping of argon ions is
achieved and a lifetime of 16s is measured. Electrostatic charging of the chip
surfaces is studied and found to agree with a numerical estimate
Formation of ultracold RbCs molecules by photoassociation
The formation of ultracold metastable RbCs molecules is observed in a double
species magneto-optical trap through photoassociation below the
^85Rb(5S_1/2)+^133Cs(6P_3/2) dissociation limit followed by spontaneous
emission. The molecules are detected by resonance enhanced two-photon
ionization. Using accurate quantum chemistry calculations of the potential
energy curves and transition dipole moment, we interpret the observed
photoassociation process as occurring at short internuclear distance, in
contrast with most previous cold atom photoassociation studies. The vibrational
levels excited by photoassociation belong to the 5th 0^+ or the 4th 0^-
electronic states correlated to the Rb(5P_1/2,3/2)+Cs(6S_1/2) dissociation
limit. The computed vibrational distribution of the produced molecules shows
that they are stabilized in deeply bound vibrational states of the lowest
triplet state. We also predict that a noticeable fraction of molecules is
produced in the lowest level of the electronic ground state
MR-guided cholecystostomy: Assessment of biplanar, real-time needle tracking in three pigs
Purpose: To demonstrate the feasibility of magnetic resonance (MR)-guided cholecystostomy using active, real-time, biplanar MR tracking in animal experiments. Methods: Experiments were performed on three fully anesthetized pigs in an interventional MR system (GE open). The gallbladder was displayed in two orthogonal planes using a heavily T2-weighted fast spin-echo sequence. These "cholangio roadmaps” were displayed on LCD monitors positioned in front of the interventionalist. A special coaxial MR-tracking needle, equipped with a small receive-only coil at its tip, was inserted percutaneously into the gallbladder under continuous, biplanar MR guidance. The MR-tracking sequence allowed sampling of the coil (needle tip) position every 120 msec. The position of the coil was projected onto the two orthogonal "cholangio roadmap” images. Results: Successful insertion of the needle was confirmed by aspiration of bile from the gallbladder. The process of aspiration and subsequent instillation of Gd-DTPA into the gallbladder was documented with fast gradient-recalled echo imaging. Conclusion: Biplanar, active, real-time MR tracking in combination with "cholangio roadmaps” allows for cholecystostomies in an interventional MRI environmen
CD90 is dispensable for white and beige/brown adipocyte differentiation
Brown adipose tissue (BAT) is a thermogenic organ in rodents and humans. In mice, the transplantation of BAT has been successfully used to combat obesity and its comorbidities. While such beneficial properties of BAT are now evident, the developmental and cellular origins of brown, beige, and white adipocytes have remained only poorly understood, especially in humans. We recently discovered that CD90 is highly expressed in stromal cells isolated from human white adipose tissue (WAT) compared to BAT. Here, we studied whether CD90 interferes with brown or white adipogenesis or white adipocyte beiging. We applied flow cytometric sorting of human adipose tissue stromal cells (ASCs), a CRISPR/Cas9 knockout strategy in the human Simpson-Golabi-Behmel syndrome (SGBS) adipocyte model system, as well as a siRNA approach in human approaches supports the hypothesis that CD90 affects brown or white adipogenesis or white adipocyte beiging in humans. Taken together, our findings call the conclusions drawn from previous studies, which claimed a central role of CD90 in adipocyte differentiation, into question
Ideal Multipole Ion Traps from Planar Ring Electrodes
We present designs for multipole ion traps based on a set of planar, annular,
concentric electrodes which require only rf potentials to confine ions. We
illustrate the desirable properties of the traps by considering a few simple
cases of confined ions. We predict that mm-scale surface traps may have trap
depths as high as tens of electron volts, or micromotion amplitudes in a 2-D
ion crystal as low as tens of nanometers, when parameters of a magnitude common
in the field are chosen. Several example traps are studied, and the scaling of
those properties with voltage, frequency, and trap scale, for small numbers of
ions, is derived. In addition, ions with very high charge-to-mass ratios may be
confined in the trap, and species of very different charge-to-mass ratios may
be simultaneously confined. Applications of these traps include quantum
information science, frequency metrology, and cold ion-atom collisions.Comment: Section on trapping of a single ion added, two figures added, one
formula corrected, otherwise minor change
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