Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK

Although a significant body of research has shown that married people are healthier and live longer, empirical research on sex differences in the link between marital status and health suggests results are mixed. Moreover, the sex disparities in marital status and health relationships vary across adulthood. The literature on partnership status and measures of ageing is largely focused on older age groups and is limited in its view of early adulthood. Data from waves 2 and 3 (2010–2012) of Understanding Society: UKHLS were used to examine the association of current partnership status with epigenetic age acceleration (AA) assessed with DNA methylation (DNAm) algorithms 'Phenoage' and ' DunedinPACE ' in 3492 participants (aged 16–97). Regression models were estimated separately for men and women, and further stratified by age groups. Divorced/separated and widowed people showed positive age acceleration compared to the married/cohabiting people (reference group). Some sex differences were apparent, especially, among the single and divorced/separated groups. Age differences were also apparent, for example in men, being single was negatively associated with DNAmAA in the youngest group, but positively in the oldest group compared to partnered counterparts. These findings illustrate the importance of partnerships on the ageing process, in particular marital change through divorce and widowhood for positive age acceleration in adults. For single groups, observations were heterogenous by age and sex

A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison

Major Depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation (DNAm) may be associated with the condition. However, previous DNAm studies have not so far been widely replicated, suggesting a need for larger meta-analysis studies. In the present study, the Psychiatric Genomics Consortium Major Depressive Disorder working group conducted a meta-analysis of methylome-wide association analysis (MWAS) for life-time MD across 18 studies of 24,754 European-ancestry participants (5,443 MD cases) and an East Asian sample (243 cases, 1846 controls). We identified fifteen CpG sites associated with lifetime MD with methylome-wide significance (p < 6.42e-8). Top CpG effect sizes in European ancestries were positively correlated with those from an independent East Asian MWAS (r = 0.482 and p = 0.068 for significant CpG sites, r = 0.261 and p = 0.009 for the top 100 CpG sites). Methylation score (MS) created using the MWAS summary statistics was significantly associated with MD status in an out-of-sample classification analysis (beta = 0.122, p = 0.005, AUC = 0.53). MS was also associated with five inflammatory markers, with the strongest association found with Tumor Necrosis Factor Beta (beta=-0.154, p=1.5e-5). Mendelian randomisation (MR) analysis demonstrated that 23 CpG sites were potentially causally associated with MD and six of those were replicated in an independent mQTL dataset (Wald's ratio test, absolute β ranged from 0.056 to 0.932, p ranged from 7e-3 to 4.58e-6). CpG sites located in the Major Histocompatibility complex (MHC) region showed the strongest evidence from MR analysis of being associated with MD. Our study provides evidence that variations in DNA methylation are associated with MD, and further evidence supporting involvement of the immune system. Larger sample sizes in diverse ancestries are likely to reveal replicable associations to improve mechanistic inferences with the potential to inform molecular target identification

Genome-wide Association Study of Long COVID

SummaryInfections can lead to persistent or long-term symptoms and diseases such as shingles after varicella zoster, cancers after human papillomavirus, or rheumatic fever after streptococcal infections1, 2. Similarly, infection by SARS-CoV-2 can result in Long COVID, a condition characterized by symptoms of fatigue and pulmonary and cognitive dysfunction3–5. The biological mechanisms that contribute to the development of Long COVID remain to be clarified. We leveraged the COVID-19 Host Genetics Initiative6, 7to perform a genome-wide association study for Long COVID including up to 6,450 Long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We identified the first genome-wide significant association for Long COVID at theFOXP4locus.FOXP4has been previously associated with COVID-19 severity6, lung function8, and cancers9, suggesting a broader role for lung function in the pathophysiology of Long COVID. While we identify COVID-19 severity as a causal risk factor for Long COVID, the impact of the genetic risk factor located in theFOXP4locus could not be solely explained by its association to severe COVID-19. Our findings further support the role of pulmonary dysfunction and COVID-19 severity in the development of Long COVID.</jats:p

Transforming an Urban \u27Burb: Transportation Innovations in Vancouver, Washington

From Complete Streets policy implementation to stronger community engagement, bus rapid transit expansion to waterfront redevelopment—and so much more!—Vancouver, Washington, is on the move. Directly across the river from Portland, Oregon, the City of Vancouver serves as the southern gateway to Washington State; the City encompasses over 50 square miles, and, with a population of nearly 185,000, Vancouver is the fourth largest city in Washington (behind Seattle, Spokane, and Tacoma and just ahead of Bellevue). As Vancouver embarks on an update to the 15-year-old Transportation System Plan, learn about how the City is striving to transform the existing transportation system through more collaborative programs and more efficient measures. Smaller and suburban cities face unique challenges in growing metropolitan areas with economic and demographic shifts—and these communities must balance multiple, sometimes differing, expectations that the transportation system will provide everyone with an excellent level of service. In the changing landscape of ever-improving mobility options, advancing technology, and evolving best practices, find out how Vancouver is working to ensure that the transportation system operates as safely, efficiently, and innovatively as possible.https://pdxscholar.library.pdx.edu/trec_seminar/1176/thumbnail.jp

Biological datasets in Understanding Society

In this video, Senior Research Officer Anna Dearman gives an overview of the biological datasets available in Understanding Society, the UK Household Longitudinal Study (UKHLS), and describes the relevant biology for lay audiences

An introduction to multi-omic data analysis methods in biosocial research

In this video, Senior Research Officer Anna Dearman describes some of the ways in which researchers are using biological “-omics” datasets, and discusses approaches which could be adopted by social scientists

Pathway 1000 Community Housing Plan

Housing prices in the City of Portland have risen dramatically in recent years, and low income and communities of color have been particularly hard hit in the northeast neighborhoods of the city. Portland Community Reinvestment Initiatives has embarked on the development of 1000 affordable units over the next 10 years to help meet the needs of displaced residents. The Pathway 1000 Community Housing Plan sets out a strategy for providing those 1000 affordable, stable homes. This project was conducted under the supervision of Marisa Zapata, Ethan Seltzer, Susam Hartnett, and Lisa Bates

Engineering geological map of the Chiavari city area (Liguria, Italy)

An engineering geological map at a scale of 1:10,000 of the Chiavari city area (Northern Italy) – a major tourist and economic attraction of the Ligurian East Riviera – is presented in this paper. The municipality land shows an excellent geomorphological case-study of the well-known Ligurian coast: a floodplain, fairly wide and inhabited, formed by several floods of the two main rivers, a hill hinterland, reasonably inhabited, developed in marly limestones and sandy shales flysch and the coast – featuring cliffs and narrow pebbly beaches – deeply modified. This map was compiled by combining available geological data with a new engineering geomorphological field survey and including geotechnical data which were obtained from studies carried out for town planning and building purposes. On the basis of the critical review of the available lithostratigraphic data from drilling, as well as geotechnical and geophysical analyses carried out between 1981 and 2010 on the municipality land, an engineering geologica..