Different conformations and packing motifs in the crystal structures of four thiophene--carbohydrazide--pyridine derivatives

Peer reviewedPublisher PD

Comparison of diverse methods for the correction of atmospheric effects on LANDSAT and SKYLAB images

Earth's atmosphere reduces a sensors ability in currently discriminating targets. Using radiometric correction to reduce the atmospheric effects may improve considerably the performance of an automatic image interpreter. Several methods for radiometric correction from the open literature are compared leading to the development of an atmospheric correction system

Angular Dependence in Proton-Proton Correlation Functions in Central 40Ca+40Ca^{40}Ca+^{40}Ca and 48Ca+48Ca^{48}Ca+^{48}Ca Reactions

The angular dependence of proton-proton correlation functions is studied in central $^{40}Ca+^{40}Ca$ and $^{48}Ca+^{48}Ca$ nuclear reactions at E=80 MeV/A. Measurements were performed with the HiRA detector complemented by the 4$\pi$ Array at NSCL. A striking angular dependence in the laboratory frame is found within p-p correlation functions for both systems that greatly exceeds the measured and expected isospin dependent difference between the neutron-rich and neutron-deficient systems. Sources measured at backward angles reflect the participant zone of the reaction, while much larger sources observed at forward angles reflect the expanding, fragmenting and evaporating projectile remnants. The decrease of the size of the source with increasing momentum is observed at backward angles while a weaker trend in the opposite direction is observed at forward angles. The results are compared to the theoretical calculations using the BUU transport model.Comment: 8 pages, 3 figures, submitted to PR

A statistical interpretation of the correlation between intermediate mass fragment multiplicity and transverse energy

Multifragment emission following Xe+Au collisions at 30, 40, 50 and 60 AMeV has been studied with multidetector systems covering nearly 4-pi in solid angle. The correlations of both the intermediate mass fragment and light charged particle multiplicities with the transverse energy are explored. A comparison is made with results from a similar system, Xe+Bi at 28 AMeV. The experimental trends are compared to statistical model predictions.Comment: 7 pages, submitted to Phys. Rev.

Circumstantial Evidence for a Critical Behavior in Peripheral Au + Au Collisions at 35 MeV/nucleon

The fragmentation resulting from peripheral Au + Au collisions at an incident energy of E = 35 MeV/nucleon is investigated. A power-law charge distribution, $A^{-\tau}$ with $\tau \approx 2.2$, and an intermittency signal are observed for events selected in the region of the Campi scatter plot where "critical" behavior is expected.Comment: 11 pages, RevTex file, 4 postscript figures available upon request from [email protected]

Identification of Novel Molecular Targets for Endometrial Cancer Using a Drill-Down LC-MS/MS Approach with iTRAQ

BACKGROUND: The number of patients with endometrial carcinoma (EmCa) with advanced stage or high histological grade is increasing and prognosis has not improved for over the last decade. There is an urgent need for the discovery of novel molecular targets for diagnosis, prognosis and treatment of EmCa, which will have the potential to improve the clinical strategy and outcome of this disease. METHODOLOGY AND RESULTS: We used a "drill-down" proteomics approach to facilitate the identification of novel molecular targets for diagnosis, prognosis and/or therapeutic intervention for EmCa. Based on peptide ions identified and their retention times in the first LC-MS/MS analysis, an exclusion list was generated for subsequent iterations. A total of 1529 proteins have been identified below the Proteinpilot® 5% error threshold from the seven sets of iTRAQ experiments performed. On average, the second iteration added 78% new peptides to those identified after the first run, while the third iteration added 36% additional peptides. Of the 1529 proteins identified, only 40 satisfied our criteria for significant differential expression in EmCa in comparison to normal proliferative tissues. These proteins included metabolic enzymes (pyruvate kinase M2 and lactate dehydrogenase A); calcium binding proteins (S100A6, calcyphosine and calumenin), and proteins involved in regulating inflammation, proliferation and invasion (annexin A1, interleukin enhancer-binding factor 3, alpha-1-antitrypsin, macrophage capping protein and cathepsin B). Network analyses revealed regulation of these molecular targets by c-myc, Her2/neu and TNF alpha, suggesting intervention with these pathways may be a promising strategy for the development of novel molecular targeted therapies for EmCa. CONCLUSIONS: Our analyses revealed the significance of drill-down proteomics approach in combination with iTRAQ to overcome some of the limitations of current proteomics strategies. This study led to the identification of a number of novel molecular targets having therapeutic potential for targeted molecular therapies for endometrial carcinoma

Searching for the Nuclear Liquid-Gas Phase Transition in Au + Au Collisions at 35 MeV/nucleon

Within the framework of Classical Molecular Dynamics, we study the collision Au + Au at an incident energy of 35 MeV/nucleon. It is found that the system shows a critical behaviour at peripheral impact parameters, revealed through the analysis of conditional moments of charge distributions, Campi Scatter Plot, and the occurrence of large fluctuations in the region of the Campi plot where this critical behaviour is expected. When applying the experimental filters of the MULTICS-MINIBALL apparatus, it is found that criticality signals can be hidden due to the inefficiency of the experimental apparatus. The signals are then recovered by identifying semi-peripheral and peripheral collisions looking to the velocity distribution of the largest fragment, then by selecting the most complete events.Comment: RevTex file, 21 pages + 19 figures available upon request from [email protected]

Understanding our seas: National Institute of Oceanography, Goa

The present article summarizes the research done at the CSIR–National Institute of Oceanography in 2014 in ocean science, resources and technology. Significant research has been conducted on air–sea interactions and coastal circulation, biogeochemistry, biology, marine geophysics, palaeoceanography, marine fishery, gas hydrates and wave energy. Technological advances covered topics like oceanographic tools. Major strides have been made in marine resources research and evaluation