Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of the biological characteristics and behaviour of metastatic OS cells may provide a rational basis for innovative treatment strategies. The aim of this review is to give an overview of the biological changes in metastatic OS cells and the preclinical and clinical efforts targeting the different steps in OS metastases and how these contribute to designing a metastasis directed treatment for OS

The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

Instrumentatio

Fabrication of Flexible Superconducting Wiring with High Current-Carrying Capacity Indium Interconnects

The X-ray integral field unit (X-IFU) is a cryogenic spectrometer for the Advanced Telescope for High ENergy Astrophysics (ATHENA). ATHENA is a planned next-generation space-based X-ray observatory with capabilities that surpass the spectral resolution of prior missions. Proposed device designs contain up to 3840 transition edge sensors, each acting as an individual pixel on the detector, presenting a unique challenge for wiring superconducting leads in the focal plane assembly. In prototypes that require direct wiring, the edges of X-IFU focal plane have hosted aluminum wirebonding pads; however, indium (In) bumps deposited on an interface layer such as molybdenum nitride (MoN) can instead be used as an array of superconducting interconnects. We investigated bumped MoN:In structures with different process cleans and layer thicknesses. Measurements of the resistive transitions showed variation of transition temperature T(sub c) as a function of bias and generally differed from the expected bulk T(sub c) of In (3.41 K). Observed resistance of the In bump structures at temperatures below the MoN transition (at 8.0 K) also depended on the varied parameters. For our proposed X-IFU geometry (10 m of In mated to a 1-m In bump), we measured a minimum T(sub c) of 3.14 K at a bias current of 3 mA and a normal resistance of 0.59 m per interconnect. We also investigated the design and fabrication of superconducting niobium (Nb) microstrip atop flexible polyimide. We present a process for integrating In bumps with the flexible Nb leads to enable high-density wiring for the ATHENA X-IFU focal plane

The TolTEC camera: an overview of the instrument and in-lab testing results

TolTEC is a three-band imaging polarimeter for the Large Millimeter Telescope. Simultaneously observing with passbands at 1.1mm, 1.4mm and 2.0mm, TolTEC has diffraction-limited beams with FWHM of 5, 7, and 11 arcsec, respectively. Over the coming decade, TolTEC will perform a combination of PI-led and Open-access Legacy Survey projects. Herein we provide an overview of the instrument and give the first quantitative measures of its performance in the lab prior to shipping to the telescope in 2021