Immunotherapy: is a minor god yet in the pantheon of treatments for lung cancer?

Immunotherapy has been studied for many years in lung cancer without significant results, making the majority of oncologists quite skeptical about its possible application for non-small cell lung cancer treatment. However, the recent knowledge about immune escape and subsequent 'cancer immunoediting' has yielded the development of new strategies of cancer immunotherapy, heralding a new era of lung cancer treatment. Cancer vaccines, including both whole-cell and peptide vaccines have been tested both in early and advanced stages of non-small cell lung cancer. New immunomodulatory agents, including anti-CTLA4, anti-PD1/PDL1 monoclonal antibodies, have been investigated as monotherapy in metastatic lung cancer. To date, these treatments have shown impressive results of efficacy and tolerability in early clinical trials, leading to testing in several large, randomized Phase III trials. As these results will be confirmed, these drugs will be available in the near future, offering new exciting therapeutic options for lung cancer treatment

Double jeopardy:subordinates' worldviews and poor performance as predictors of abusive supervision

Purpose - To test a moderated mediation model where a positive relationship between subordinates’ perceptions of a dangerous world—the extent to which an individual views the world as a dangerous place—and supervisory abuse is mediated by their submission to authority figures, and that this relationship is heightened for more poorly performing employees. Design/Methodology/Approach - Data were obtained from 173 subordinates and 45 supervisors working in different private sector organizations in Pakistan. Findings - Our model was supported. It appears that subordinates’ dangerous worldviews are positively associated with their perceptions of abusive supervision and that this is because such views are likely to lead to greater submission to authority figures. But this is only for those employees who are performing more poorly. Implications - We highlight the possibility that individual differences (worldviews, attitudes to authority figures, and performance levels) may lead employees to become victims of abusive supervision. As such, our research informs organizations on how they may better support supervisors in managing effectively their subordinate relationships and, in particular, subordinate poor performance. Originality/Value - We add to recent work exploring subordinate-focused antecedents of abusive supervision, finding support for the salience of the previously untested constructs of individual worldviews, authoritarian submission, and individual job performance. In so doing we also extend research on dangerous worldviews into a new organizational setting. Finally, our research takes place within a new Pakistani context, adding to the burgeoning non-US based body of empirical work into the antecedents and consequences of abusive supervision

Influence of the projectile geometry on the momentum transfer from a kinetic impactor and implications for the DART mission

The DART spacecraft will impact Didymos’s secondary, Dimorphos, at the end of 2022 and cause a change in the orbital period of the secondary. For simplicity, most previous numerical simulations of the impact used a spherical projectile geometry to model the DART spacecraft. To investigate the effects of alternative, simple projectile geometries on the DART impact outcome we used the iSALE shock physics code in two and thee-dimensions to model vertical impacts of projectiles with a mass and speed equivalent to the nominal DART impact, into porous basalt targets. We found that the simple projectile geometries investigated here have minimal effects on the crater morphology and momentum enhancement. Projectile geometries modelled in two-dimensions that have similar surface areas at the point of impact, affect the crater radius and the crater volume by less than 5%. In the case of a more extreme projectile geometry (i.e., a rod, modelled in three-dimensions), the crater was elliptical and 50% shallower compared to the crater produced by a spherical projectile of the same momentum. The momentum enhancement factor in these test cases, commonly referred to as , was within 7% for the 2D simulations and within 10% for the 3D simulations, of the value obtained for a uniform spherical projectile. The most prominent effects of projectile geometry are seen in the ejection velocity as a function of launch position and ejection angle of the fast ejecta that resides in the so-called ‘coupling zone’. These results will inform the LICIACube ejecta cone analysis

Analysis of responder-based endpoints: improving power through utilising continuous components

Astro-WISE is a scientific information system for the data processing of optical images. In this paper we review main features of Astro-WISE and describe the current status of the system.Comment: 4 pages, Proc. of ADASS XXI, ASP Conference Serie