Hard sphere colloidal dispersions: Mechanical relaxation pertaining to thermodynamic forces

The complex viscosity of sterically stabilized (hard) silica spheres in cyclohexane has been measured between 80 Hz and 170 kHz with torsion pendulums and a nickel tube resonator. The observed relaxation behaviour can be attributed to the interplay of hydrodynamic and thermodynamic forces. The validity of the Cox-Merz rule is checked

The detection of deception within investigative contexts: Key challenges and core issues

A large and continually-growing body of research has explored the ways in which deception might be detected. The area is developing rapidly, opening up new avenues of study. This special issue of the Journal of Investigative Psychology and Offender Profiling brings together an exciting array of papers on the detection of deception within investigative contexts, examining a wide range of issues including; the efficacy of different interviewing techniques, the reliability of statement veracity assessment, factors influencing ability to detect deception and the need for applied research and ecologically valid studies. This examination of the key challenges and core issues surrounding the detection of deception within the criminal justice domain helps move the field forward, providing powerful results that have potentially far-reaching impacts. These are considered in detail throughout the following discussion

Adhesive Hard-Sphere Colloidal Dispersions. A Small-Angle Neutron-Scattering Study of Stickiness and the Structure Factor

Small-angle neutron-scattering structure factor measurements were made on sterically stabilized silica spheres dispersed in benzene up to volume fractions of 0.30. Benzene is only a marginal solvent for the stabilizing layer on the surface of the particles. The particles are made attractive by lowering temperature. This attraction is modeled by a square well potential, the depth of which varies with temperature. At the highest temperature studied, our experimental system behaved effectively as an assembly of hard spheres, whereas at the lowest temperature the system approaches a spinodal. Using Baxter's theory we were able to evaluate the interaction parameters and to calculate the structure factor. Experimental structure factors were satisfactorily reproduced over the entire temperature range studied

How hibernation and hypothermia help to improve anticoagulant control

Winter is coming. Some animals successfully cope with the hostility of this season by hibernating. But how do hibernators survive the procoagulant state of months of immobility at very low body temperatures, with strongly decreased blood flow and increased blood viscosity? Changing the coagulation system seems crucial for preventing thromboembolic complications

Improvement of oncolytic adenovirus vectors through genetic capsid modifications

Recombinant viral vectors hold great promise in the field of cancer gene therapy. While a plethora of viruses is being evaluated as oncolytic agents, human adenoviruses of serotype 5 (HAdV-5) are among the most popular of viruses to be developed. Although clinical studies have demonstrated safety of cancer gene therapy with HAdV-5-derived vectors, the efficacy still needs further enhancement. Several factors have been identified that limit the anti-tumor efficacy. One major bottleneck is the inadequate penetration and spread of the virus within the tumor. This is attributable, at least in part, to the low or heterogeneous expression of the coxsackie and adenovirus receptor (CAR) on the tumor cells. This thesis describes the development and preclinical evaluation of novel tumor-targeted HAdV-5 vectors, through implementing the genetic fusion of capsid proteins (protein IX and fiber) with a variety of tumor-targetin g polypeptides.European Union - 6th Framework Program GIANT (contract no. 512087)UBL - phd migration 201