Role of Genetic and Acquired Prothrombotic Risk Factors in Genesis of Sudden Sensorineural Hearing Loss.

The methylenetetrahydrofolate reductase C677T mutation, factor V G1691A (factor V Leiden) mutation, prothrombin G20210A mutation and 8 other laboratory values associated with increased thrombotic risk were analyzed in 40 patients with sudden sensorineural hearing loss (SSHL). The results were compared with those obtained from 120 controls not affected by SSHL. We found a statistically significant higher frequency of hyperhomocysteinemia in the SSHL group compared with controls, and that this was also associated with the presence of homozygosity for the MTHFR C677T mutation. The study results suggest that SSHL might be caused, among other factors, by a combination of these 2 variables. We suggest that this analysis of the MTHFR C677T mutation should be further investigated to establish the etiology of SSHL, and that the same analysis should be taken into account in those patients with high levels of homocysteine

Development and validation of a scale to measure social isolation in adolescents

Background: There is a lack of questionnaires specifically designed to assess social isolation in adolescents. We developed and validated a self-report measure of social isolation in adolescents, the Social Isolation Questionnaire (QIS). Methods: A literature review on social isolation and mental health in adolescents indicated 20 questions to form QIS. Two cross-sectional surveys with 48 and 1,135 adolescents, respectively, evaluated the reproducibility and validity of QIS. Results: The Bland-Altman plot did not indicate a systematic difference between measurements 15 days apart. Bartlett’s sphericity test verified a correlation between the questions and the Kaiser-Meyer-Olkin test showed good adequacy (0.896) to the factor analysis. Exploratory factor analysis suggested the exclusion of three questions (loading factors <0.3), and eigenvalues (4.9 to 0.8) indicated that the questionnaire should be composed of three factors (dimensions). The Cronbach’s alpha indicated high internal consistency of the 17 questions (0.850 overall; Dimensions: 0.815 ‘feeling of loneliness’; 0.760 ‘friendship’; and, 0.680 ‘Family support’). The QIS score ranged from 0 to 131 (maximum social isolation score). Correlation between QIS and depressive symptoms (r=0.543) indicated the construct validity of QIS. Limitations: We evaluated QIS in the Portuguese version, thus translation and cultural adaptation are necessary to evaluate the questionnaire in other settings. Conclusions: We constructed and validated the QIS questionnaire, a self-administered questionnaire to assess social isolation in adolescents, composed of three dimensions; feeling of loneliness, friendship and family support. The QIS questionnaire seems a very promising tool to support practitioners and researchers in assessing social isolation among adolescents

CD-62°1346: An extreme halo or hypervelocity CH star?

High-velocity halo stars provide important information about the properties of the extreme Galactic halo. The study of unbound and bound Population II stars permits us to better estimate the mass of the halo. Aims: We carried out a detailed spectroscopic and kinematic study and have significantly refined the distance and the evolutionary state of the star. Methods: Its atmospheric parameters, chemical abundances and kinematical properties were determined using high-resolution optical spectroscopy and employing the local-thermodynamic-equilibrium model atmospheres of Kurucz and the spectral analysis code moog. Results: We found that CD-62°1346 is a metal-poor ([Fe/H] = -1.6) evolved giant star with Teff = 5300 K and log g = 1.7. The star exhibits high carbon and s-element abundances typical of CH stars. It is also a lead star. Our kinematic analysis of its 3D space motions shows that this star has a highly eccentric (e = 0.91) retrograde orbit with an apogalactic distance of ~100 kpc, exceeding by a factor of two the distance of the Magellanic Clouds. The star travels with very high velocity relative to the Galactocentric reference frame (VGRF = 570 km s-1). Conclusions: CD-62°1346 is an evolved giant star and not a subgiant star, as was considered earlier. Whether it is bound or unbound to the Galaxy depends on the assumed mass and on the adopted Galactic potential. We also show that the star HD 5223 is another example of a high-velocity CH star that exceeds the Galactic escape velocity. Possible origins of these two high-velocity stars are briefly discussed. CD-62°1346 and HD 5223 are the first red giant stars to join the restricted group of hypervelocity stars.Fil: Pereira, C. B.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Jilinski, E.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Universidade do Estado de Rio do Janeiro; Brasil. Russian Academy of Sciences. Pulkovo Observatory; RusiaFil: Drake, N. A.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Russian Academy of Sciences. Pulkovo Observatory; RusiaFil: de Castro, D. B.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Ortega, V. G.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Chavero, Carolina Andrea. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Roig, Fernando Virgilio. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasi

The GINGER Project and status of the ring-laser of LNGS

A ring-laser attached to the Earth measures the absolute angular velocity of the Earth summed to the relativistic precessions, de Sitter and Lense-Thirring. GINGER (Gyroscopes IN GEneral Relativity) is a project aiming at measuring the LenseThirring effect with a ground based detector; it is based on an array of ring-lasers. Comparing the Earth angular velocity measured by IERS and the measurement done with the GINGER array, the Lense-Thirring effect can be evaluated. Compared to the existing space experiments, GINGER provides a local measurement, not the averaged value and it is unnecessary to model the gravitational field. It is a proposal, but it is not far from being a reality. In fact the GrossRing G of the Geodesy Observatory of Wettzell has a sensitivity very close to the necessary one. G ofWettzell is part of the IERS system which provides the measure of the Length Of the DAY (LOD); G provides information on the fast component of LOD. In the last few years, a roadmap toward GINGER has been outlined. The experiment G-GranSasso, financed by the INFN Commission II, is developing instrumentations and tests along the roadmap of GINGER. In this short paper the main activities of G-GranSasso and some results will be presented. The first results of GINGERino will be reported, GINGERino is the large ring-laser installed inside LNGS and now in the commissioning phase. Ring-lasers provide as well important informations for geophysics, in particular the rotational seismology, which is an emerging field of science. GINGERino is one of the three experiments of common interest between INFN and INGV

The observed oogenesis impairment in greater amberjack Seriola dumerili (Risso, 1810) reared in captivity is not related to an insufficient liver transcription or oocyte uptake of vitellogenin

The greater amberjack Seriola dumerili is an excellent candidate for the Mediterranean aquaculture, due to its large body size and high growth rate, as well as its high flesh quality and commercial value worldwide. For its successful incorporation in the aquaculture industry, an in-depth understanding of the reproductive function of the species under rearing conditions is necessary, since completion of oogenesis in captivity is currently a bottleneck for the commercial production of the species. Liver and ovary samples from wild and captive-reared greater amberjack females were collected at three different phases of the reproductive cycle: early gametogenesis (EARLY, late April-early May), advanced gametogenesis (ADVANCED, late May-early June) and spawning (SPAWNING, late June-July). The cDNAs of three vitellogenins (VtgA, VtgB and VtgC) were partially sequenced and a qRT-PCR for their expression was used to compare ovarian maturity stage and liver vitellogenin transcript levels between wild and captive-reared individuals. An extensive atresia of late vitellogenic follicles, which prevented any further oocyte development and spawning was observed in captive-reared individuals during the ADVANCED phase. The expression levels of the three vitellogenins, as well as the amount of yolk globules in vitellogenic oocytes, did not differ significantly between captive-reared and wild females, indicating that the observed oogenesis impairment in greater amberjack reared in captivity was not related to an insufficient liver synthesis or a reduced oocyte uptake of vitellogenin

Management of oxygen saturation monitoring in preterm newborns in the NICU: the Italian picture

Background: Although many studies emphasize the importance of using oxygen saturation (SpO2) targets in the NICUs, there is a wide variability in used saturation ranges among centers. Primary aim was to draw a representative picture on how the management of oxygen monitoring is performed in the Italian NICUs. Second aim was to identify healthcare-professionals related factors associated with oxygen targeting in the preterm population. Methods: Cross-sectional study with data collection via an electronic survey form. A questionnaire containing pre-piloted and open questions on monitoring and management of the SpO2 was administered to neonatologists across the network of the Italian Society of Neonatology. The questions focused on: the infrastructure, specific training, healthcare professionals and patients-related factors. The results of the survey were anonymously collected, summarized and analyzed. Results: Out of 378 questionnaires, 93 were correctly filled. Thirty-six different SpO2 ranges were observed. Centers using written standard operating procedures on oxygen management and SpO2 monitoring maintained a correct average range of SpO2 90–95%, avoided hyperoxia and reconsidered saturation targets in relation to comorbidities. 39.8% of responders disabled alarms during neonatal care. One center used biomarkers for complete monitoring of neonatal oxygenation status. Conclusions: There is considerable variation in SpO2 targets for preterm infants in the Italian NICUs. Standard operating procedures and specific training for health care personnel are the main factors playing a role for the correct maintenance of the recommended oxygen targets in preterms

Systematics of Afrotropical Eristalinae (Diptera: Syrphidae) using mitochondrial phylogenomics

Published online: 11 Jan 2022We examined the phylogeny and intrageneric classification of eristaline hoverfly genera from the Afrotropical Region using mitochondrial genomes. Genome skimming was used to obtain (nearly) full mtDNA and nuclear rDNA (18S, 28S) genomes of 120 museum vouchers from eight genera and 98 species. Phylogenetic reconstructions of mitogenomes and mitogenomes + nuclear rDNA yielded comparable phylogenies while that of rDNA only resulted in poorly resolved phylogenies. Phylogenetic analyses focused on six genera and supported the monophyly of the general Chasmomma Bezzi, Eristalinus Rondani, Mesembrius Rondani and Syritta Le Peletier & Serville, whereas Simoides Loew was not monophyletic and rendered Phytomia Guérin-Méneville paraphyletic. We therefore synonymize Simoides with Phytomia. Within Chasmomma, two species-groups that differ in the colour and the shape of the hind femora (Chasmomma femoratum and Chasmomma nigrum species-groups) were supported. Within Eristalinus, the monophyly of the subgenera Merodonoides Curran and Eristalodes Mik was supported, but not of the subgenus Eristalinus Rondani. Within Syritta, the monophyly of three out of the five species-groups tested was rejected. This approach illustrates the importance of integrative and iterative approaches in taxonomy and shows that genomic data may not only clarify the systematic relationships among hoverfly genera and species, but also offer perspectives into the evolution of morphological and ecological variation within the family

Deep underground rotation measurements: GINGERino ring laser gyroscope in Gran Sasso

GINGERino is a large frame laser gyroscope investigating the ground motion in the most inner part of the underground international laboratory of the Gran Sasso, in central Italy. It consists of a square ring laser with a $3.6$ m side. Several days of continuous measurements have been collected, with the apparatus running unattended. The power spectral density in the seismic bandwidth is at the level of $10^{-10} \rm{(rad/s)/\sqrt{Hz}}$. A maximum resolution of $30\,\rm{prad/s}$ is obtained with an integration time of few hundred seconds. The ring laser routinely detects seismic rotations induced by both regional earthquakes and teleseisms. A broadband seismic station is installed on the same structure of the gyroscope. First analysis of the correlation between the rotational and the translational signal are presented.Published0345027TM. Sviluppo e Trasferimento TecnologicoJCR Journa