Accretion and photodesorption of CO ice as a function of the incident angle of deposition

Non-thermal desorption of inter- and circum-stellar ice mantles on dust grains, in particular ultraviolet photon-induced desorption, has gained importance in recent years. These processes may account for the observed gas phase abundances of molecules like CO toward cold interstellar clouds. Ice mantle growth results from gas molecules impinging on the dust from all directions and incidence angles. Nevertheless, the effect of the incident angle for deposition on ice photo-desorption rate has not been studied. This work explores the impact on the accretion and photodesorption rates of the incidence angle of CO gas molecules with the cold surface during deposition of a CO ice layer. Infrared spectroscopy monitored CO ice upon deposition at different angles, ultraviolet-irradiation, and subsequent warm-up. Vacuum-ultraviolet spectroscopy and a Ni-mesh measured the emission of the ultraviolet lamp. Molecules ejected from the ice to the gas during irradiation or warm-up were characterized by a quadrupole mass spectrometer. The photodesorption rate of CO ice deposited at 11 K and different incident angles was rather stable between 0 and 45$^{\circ}$. A maximum in the CO photodesorption rate appeared around 70$^{\circ}$-incidence deposition angle. The same deposition angle leads to the maximum surface area of water ice. Although this study of the surface area could not be performed for CO ice, the similar angle dependence in the photodesorption and the ice surface area suggests that they are closely related. Further evidence for a dependence of CO ice morphology on deposition angle is provided by thermal desorption of CO ice experiments

Massive pre-main sequence stars in M17

The formation process of massive stars is still poorly understood. Massive young stellar objects (mYSOs) are deeply embedded in their parental clouds, they are rare and thus typically distant, and their reddened spectra usually preclude the determination of their photospheric parameters. M17 is one of the best studied HII regions in the sky, is relatively nearby, and hosts a young stellar population. With X-shooter on the ESO Very Large Telescope we have obtained optical to near-infrared spectra of candidate mYSOs, identified by Hanson et al. (1997), and a few OB stars in this region. The large wavelength coverage enables a detailed spectroscopic analysis of their photospheres and circumstellar disks. We confirm the pre-main sequence (PMS) nature of six of the stars and characterise the O stars. The PMS stars have radii consistent with being contracting towards the main sequence and are surrounded by a remnant accretion disk. The observed infrared excess and the (double-peaked) emission lines provide the opportunity to measure structured velocity profiles in the disks. We compare the observed properties of this unique sample of young massive stars with evolutionary tracks of massive protostars by Hosokawa & Omukai (2009), and propose that these mYSOs near the western edge of the HII region are on their way to become main-sequence stars ($\sim 6 - 20$ $M_{\odot}$) after having undergone high mass-accretion rates (${\dot{M}_{\rm acc}} \sim 10^{-4} - 10^{-3}$ $M_{\odot}$ $\rm yr^{-1}$). Their spin distribution upon arrival at the zero age main sequence (ZAMS) is consistent with that observed for young B stars, assuming conservation of angular momentum and homologous contraction.Comment: Accepted for publication in A&A. Appendixes A and B have been truncated due to size limitations, the full version will be available on A&

Tr\'{e}maux trees and planarity

We present a simplified version of the DFS-based Left-Right planarity testing and embedding algorithm implemented in Pigale which has been considered as the fastest implemented one [J.M. Boyer, P.F. Cortese, M. Patrignani, and G. Di Battista. Stop minding your P's and Q's: implementing fast and simple DFS-based planarity and embedding algorithm. In Graph Drawing, volume 2912 of Lecture Notes in Computer Science, pages 25-36. Springer, 2004.]. We give here a simple full justification of the algorithm, based on a preliminary extended study of topological properties of DFS trees.Comment: Special Issue on Graph Drawin

Teste alternativo para avaliação do potencial fisiológico de sementes de milho e feijão de porco.

bitstream/item/56906/1/COT89-lancado.pd

Spin observables for pion photoproduction on the deuteron in the Δ\Delta(1232)-resonance region

Spin observables for the three charge states of the pion for the pion photoproduction reaction on the deuteron, $\gamma d\to\pi NN$, with polarized photon beam and/or oriented deuteron target are predicted. For the beam-target double-spin asymmetries, it is found that only the longitudinal asymmetries $T_{20}^{\ell}$ and $T_{2\pm 2}^{\ell}$ do not vanish, whereas all the circular and the other longitudinal asymmetries do vanish. The sensitivity of spin observables to the model deuteron wave function is investigated. It has been found that only $T_{21}$ and $T_{22}$ are sensitive to the model deuteron wave function, in particular in the case of $\pi^0$-production above the $\Delta$-region, and that other asymmetries are not.Comment: 16 pages, 8 figures, accepted for publication in J. Phys. G: Nucl. Part. Phy

Determining and Controlling External Power Output During Regular Handrim Wheelchair Propulsion

The use of a manual wheelchair is critical to 1% of the world's population. Human powered wheeled mobility research has considerably matured, which has led to improved research techniques becoming available over the last decades. To increase the understanding of wheeled mobility performance, monitoring, training, skill acquisition, and optimization of the wheelchair-user interface in rehabilitation, daily life, and sports, further standardization of measurement set-ups and analyses is required. A crucial stepping-stone is the accurate measurement and standardization of external power output (measured in Watts), which is pivotal for the interpretation and comparison of experiments aiming to improve rehabilitation practice, activities of daily living, and adaptive sports. The different methodologies and advantages of accurate power output determination during overground, treadmill, and ergometer-based testing are presented and discussed in detail. Overground propulsion provides the most externally valid mode for testing, but standardization can be troublesome. Treadmill propulsion is mechanically similar to overground propulsion, but turning and accelerating is not possible. An ergometer is the most constrained and standardization is relatively easy. The goal is to stimulate good practice and standardization to facilitate the further development of theory and its application among research facilities and applied clinical and sports sciences around the world

Side-lobe level reduction in bio-inspired optical phased-array antennas

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQPhased arrays are expected to play a critical role in visible and infrared wireless systems. Their improved performance compared to single element antennas finds uses in communications, imaging, and sensing. However, fabrication of photonic antennas and their feeding network require long element separation, leading to the appearance of secondary radiation lobes and, consequently, crosstalk and interference. In this work, we experimentally show that by arranging the elements according to the Fermat's spiral, the side lobe level (SLL) can be reduced. This reduction is proved in a CMOS-compatible 8-element array, revealing a SLL decrement of 0.9 dB. Arrays with larger numbers of elements and inter-element spacing are demonstrated through a spatial light modulator (SLM) and an SLL drop of 6.9 dB is measured for a 64-element array. The reduced SLL, consequently, makes the proposed approach a promising candidate for applications in which antenna gain, power loss, or information security are key requirements.25243010530114COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQSem informação08/57857-22013/20180-32015/04113-0574017/2008-9446746/2014-

Phase IB study of doxorubicin in combination with the multidrug resistance reversing agent S9788 in advanced colorectal and renal cell cancer.

S9788 is a new triazineaminopiperidine derivate capable of reversing multidrug resistance (MDR) in cells resistant to chemotherapeutic agents such as doxorubicin. It does not belong to a known class of MDR revertants, but its action involves the binding of P-glycoprotein. Thirty-eight evaluable patients with advanced colorectal or renal cell cancer were treated with doxorubicin alone (16 patients) followed after disease progression with combination treatment of doxorubicin plus S9788 (12 patients) or upfront with the combination of doxorubicin plus S9788 (22 patients). S9788 was given i.v. as a loading dose of 56 mg m-2 over 30 min followed by doxorubicin given at 50 mg m-2 as a bolus infusion. Thereafter, a 2-h infusion of S9788 was administered at escalating doses ranging from 24 to 120 mg m-2 in subsequent cohorts of 4-10 patients. Pharmacokinetic analysis demonstrated that concentrations of S9788 that are known to reverse MDR in vitro were achieved in patients at non-toxic doses. Compared with treatment with doxorubicin alone, treatment with the combination of doxorubicin and S9788 produced a significant increase in the occurrence of WHO grade 3-4 granulocytopenia. Treatment with S9788 was cardiotoxic as it caused a dose-dependent and reversible increase in corrected QT intervals as well as clinically non-significant arrhythmias on 24- or 48-h Holter recordings. Although clinically relevant cardiac toxicities did not occur, the study was terminated as higher doses of S9788 may increase the risk of severe cardiac arrhythmias. Twenty-nine patients treated with S9788 plus doxorubicin were evaluable for response, and one patient, who progressed after treatment with doxorubicin alone, achieved a partial response. We conclude that S9788 administered at the doses and schedule used in this study results in relevant plasma concentrations in humans and can safely be administered in combination with doxorubicin

MRI evaluation of shoulder pathologies in wheelchair users with spinal cord injury and the relation to shoulder pain

OBJECTIVE: To describe the number, specifics and co-occurrence of shoulder pathologies detected by MRI in manual wheelchair users with spinal cord injury and to evaluate the association between shoulder pathologies and presence of shoulder pain.DESIGN: Cross-sectional observation study.SETTING: Community.PARTICIPANTS: Fifty-one wheelchair-dependent persons with spinal cord injury (44 males, 7 females, median age 50 years (IQR 14), median time since injury 24 years (IQR 16)) were allocated to pain or no-pain group based on the Wheelchair User Shoulder Pain Index.INTERVENTIONS: Not applicable.OUTCOME MEASURES: All persons underwent shoulder MRI. Pathologies were scored blinded by two experienced radiologists. Participant characteristics, number and severity of shoulder pathologies were analyzed descriptively. Logistic regression was performed to evaluate the association between MRI findings and shoulder pain.RESULTS: The median number of co-occurring MRI findings per person ranged from 0 to 19 (out of 31 possible findings). The cluster of MRI findings occurring most often together were tendon tears of supraspinatus (present in 84%), subscapularis (69%) and biceps (67%) and osteoarthritis of acromioclavicular joint (80%). When correcting for age and time since injury, the logistic regression showed no statistically significant correlation between the individual pathologies and shoulder pain.CONCLUSION: MRI findings of shoulder pathology are very frequent in persons with and without shoulder pain. Therefore, when diagnosing the cause of shoulder pain and planning interventions, health care professionals should keep this finding in mind and MRI should not be interpreted without careful consideration of clinical history and functional testing.</p