12,812 research outputs found
Nonlinear elastic model for faceting of vesicles with soft grain boundaries
We use an elastic model to explore faceting of solid-wall vesicles with
elastic heterogeneities. We show that faceting occurs in regions where the
vesicle wall is softer, such as areas of reduced wall thicknesses or
concentrated in crystalline defects. The elastic heterogeneities are modeled as
a second component with reduced elastic parameters. Using simulated annealing
Monte Carlo simulations we obtain the vesicle shape by optimizing the
distributions of facets and boundaries. Our model allows us to reduce the
effects of the residual stress generated by crystalline defects, and reveals a
robust faceting mechanism into polyhedra other than the icosahedron.Comment: 4.5 pages, 4 figure
Zeta Potential of Modified Multi-walled Carbon Nanotubes in Presence of poly (vinyl alcohol) Hydrogel
The main objective of this study is investigate the behavior of the Zeta Potential of the MWCNT modified with SDS(Sodium Dodecyl Sulfate) and CTAB(Cetyl Tetraethyl Ammonium Bromide) in presence of PVA. Full hydrolyzed PVA was used. As a result, adding PVA in the CNT solution led to decrease the Zeta Potential. The Zeta Potential of suspended colloid varied from 42.00mV to 6.48mV and -45.00mV to -6.4mV at 1.5% concentration of PVA; according with the changing pH, the Zeta Potential dropped to near zero at pH 3 and 11. The pH and PVA has strong influence in the reduction of ZP of MWCNT solution. MWCNT-PVA solution with 33.30mV, -35.69mV at 0.01% of PVA was exposed under AC field; a uniform coat was obtained, with the SDS-MWCNT-PVA solution.National Natural Science Foundation of China Project (Grant No.51073024), the Royal Society-NSFC international joint project (Grant No.51111130207) and Beijing Municipal Science and Technology Plan Projects (No. Z111103066611005)
Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress.
Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by stimulating mitochondrial biogenesis. Here, we examine the neurodegenerative and aging consequences of altering CycD/Cdk4 function in Drosophila. We show that pan-neuronal loss or gain of CycD/Cdk4 increases mitochondrial superoxide, oxidative stress markers, and neurodegeneration and decreases lifespan. We find that RNAi-mediated depletion of the mitochondrial transcription factor, Tfam, can abrogate CycD/Cdk4's detrimental effects on both lifespan and neurodegeneration. This indicates that CycD/Cdk4's pathological consequences are mediated through altered mitochondrial function and a concomitant increase in reactive oxygen species. In support of this, we demonstrate that CycD/Cdk4 activity levels in the brain affect the expression of a set of 'oxidative stress' genes. Our results indicate that the precise regulation of neuronal CycD/Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration
Charged Particles on Surfaces: Coexistence of Dilute Phases and Periodic Structures on Membranes
We consider a mixture of one neutral and two oppositely charged types of
molecules confined to a surface. Using analytical techniques and molecular
dynamics simulations, we construct the phase diagram of the system and exhibit
the coexistence between a patterned solid phase and a charge-dilute phase. The
patterns in the solid phase arise from competition between short-range
immiscibility and long-range electrostatic attractions between the charged
species. The coexistence between phases leads to observations of stable
patterned domains immersed in a neutral matrix background.Comment: 5 pages, 3 figure
Photon spectra from WIMP annihilation
If the present dark matter in the Universe annihilates into Standard Model
particles, it must contribute to the fluxes of cosmic rays that are detected on
the Earth, and in particular, to the observed gamma ray fluxes. The magnitude
of such contribution depends on the particular dark matter candidate, but
certain features of the produced photon spectra may be analyzed in a rather
model-independent fashion. In this work we provide the complete photon spectra
coming from WIMP annihilation into Standard Model particle-antiparticle pairs
obtained by extensive Monte Carlo simulations. We present results for each
individual annihilation channel and provide analytical fitting formulae for the
different spectra for a wide range of WIMP masses.Comment: 23 pages, 37 figures and 23 table
Evaluation of the shrinkage and creep of medium strength self compacting concrete
The difference between self compacting concrete (SCC) and conventional concrete (CC) is in fresh state, is the high fluidity at first and the need for vibration at second, but in hardened state, both concretes must comply with the resistance specified, in addition to securing the safety and functionality for which it was designed. This article describes the tests and results for shrinkage and creep at some medium strength Self Compacting Concrete with added sand (SCC-MSs) and two types of cement. The research was conducted at the
Laboratorio de TecnologĂa de Estructuras (LTE) of the Universitat PolitĂ©cnica de Catalunya (UPC), in dosages of 200 liters; with the idea of evaluating the effectiveness of implementation of these new concretes at elements designed with conventional concrete (CCs).Peer ReviewedPostprint (published version
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