Inhibition of Acetylcholinesterase by N-Alkylpyridinium and N-Alkylpyridinium-2-aldoxime Salts

The interaction of a series of N-a1kylpyridinium and N-alkylpyridinium- 2-aldoxime salts with bovine erythrocyte acetylcholinesterase was investigated for inhibition of the hydrolysis of the substrates acetylcholine and dimethylaminoethyl acetate. The compounds cause a mixed inhibition of the acetylcholine hydrolysis which is interpreted as an interaction with the free enzyme (competitive component) and with the acetylenzyme (non- competitive component). The results suggest that the compounds have a higher affinity for the free enzyme than for the acetyl- enzyme. Enlargement of the alkyl-group increases the binding capacity to the free enzyme. The aldoxime group hardly effects the binding to the free enzyme, but tends to increase the binding to the acetyl-enzyme. Some results obtained with dimethylaminoethyl acetate support the mechanism of inhibition as proposed from acetylcholine hydrolysis inhibition. In contrast to this mechanism some compounds do not influence or even increase the maximum velocity of the dimethylaminoethyl acetate hydrolysis. It is suggested that a ternary complex of enzyme, substrate and pyridinium compound may be formed from which, in case of dimethylaminoethyl acetate, the enzyme is more rapidly acetylated

Inhibition of Acetylcholinesterase by N-Alkylpyridinium and N-Alkylpyridinium-2-aldoxime Salts

The interaction of a series of N-a1kylpyridinium and N-alkylpyridinium- 2-aldoxime salts with bovine erythrocyte acetylcholinesterase was investigated for inhibition of the hydrolysis of the substrates acetylcholine and dimethylaminoethyl acetate. The compounds cause a mixed inhibition of the acetylcholine hydrolysis which is interpreted as an interaction with the free enzyme (competitive component) and with the acetylenzyme (non- competitive component). The results suggest that the compounds have a higher affinity for the free enzyme than for the acetyl- enzyme. Enlargement of the alkyl-group increases the binding capacity to the free enzyme. The aldoxime group hardly effects the binding to the free enzyme, but tends to increase the binding to the acetyl-enzyme. Some results obtained with dimethylaminoethyl acetate support the mechanism of inhibition as proposed from acetylcholine hydrolysis inhibition. In contrast to this mechanism some compounds do not influence or even increase the maximum velocity of the dimethylaminoethyl acetate hydrolysis. It is suggested that a ternary complex of enzyme, substrate and pyridinium compound may be formed from which, in case of dimethylaminoethyl acetate, the enzyme is more rapidly acetylated

Adaptive mutation using statistics mechanism for genetic algorithms

Copyright @ 2004 Springer-Verla

Galaxies with Spiral Structure up to z = 0.87 --Limits on M/L and the Stellar Velocity Dispersion

We consider seven distant galaxies with clearly evident spiral structure from HST images. Three of these were chosen from Vogt et al. (1996) (VFP) and have measured rotational velocities. Five were chosen from the Medium Deep Survey and are studied in Sarajedini et al. 1996 (SGGR), and one galaxy is found in both papers. We place upper limits on their mass-to-light ratios (M/L) by computing M/L_B for a maximal disk. We find that these galaxies have maximal disk mass-to-light ratios M/L_B = 1.5 - 3.5 M_sol/L_Bsol at the low end, but within the range seen in nearby galaxies. The mass-to-light ratios are low enough to suggest that the galaxies contain a young, rapidly formed stellar population. By using a Toomre stability criterion for formation of spiral structure, we place constraints on the ratio of M/L to the stellar velocity dispersion. If these galaxies have maximal disks they would have to be nearly unstable so as to have small enough velocity dispersions that their disks are not unrealistically thick. This suggests that there is a substantial amount of dark matter present in the luminous regions of the galaxy.Comment: AAS Latex + PS Figure, accepted for publication in A

Structure of Disk Dominated Galaxies I. Bulge/Disk Parameters, Simulations, and Secular Evolution

(Abridged) A robust analysis of galaxy structural parameters, based on the modeling of bulge and disk brightnesses in the BVRH bandpasses, is presented for 121 face-on and moderately inclined late-type spirals. Each surface brightness (SB) profile is decomposed into a sum of a generalized Sersic bulge and an exponential disk. The reliability and limitations of our bulge-to-disk (B/D) decompositions are tested with extensive simulations of galaxy brightness profiles (1D) and images (2D). Galaxy types are divided into 3 classes according to their SB profile shapes; Freeman Type-I and Type-II, and a third ``Transition'' class for galaxies whose profiles change from Type-II in the optical to Type-I in the infrared. We discuss possible interpretations of Freeman Type-II profiles. The Sersic bulge shape parameter for nearby Type-I late-type spirals shows a range between n=0.1-2 but, on average, the underlying surface density profile for the bulge and disk of these galaxies is adequately described by a double-exponential distribution. We confirm a coupling between the bulge and disk with a scale length ratio r_e/h=0.22+/-0.09, or h_bulge/h_disk=0.13+/-0.06 for late-type spirals, in agreement with recent N-body simulations of disk formation and models of secular evolution. This ratio increases from ~0.20 for late-type spirals to ~0.24 for earlier types. The similar scaling relations for early and late-type spirals suggest comparable formation and/or evolution scenarios for disk galaxies of all Hubble types.Comment: 78 pages with 23 embedded color figures + tables of galaxy structural parameters. Accepted for publication in the Astrophysical Journal. The interested reader is strongly encouraged to ignore some of the low res figures within; instead, download the high resolution version from http://www.astro.ubc.ca/people/courteau/public/macarthur02_disks.ps.g

Exploring the Structure of Distant Galaxies with Adaptive Optics on the Keck-II Telescope

We report on the first observation of cosmologically distant field galaxies with an high order Adaptive Optics (AO) system on an 8-10 meter class telescope. Two galaxies were observed at 1.6 microns at an angular resolution as high as 50 milliarcsec using the AO system on the Keck-II telescope. Radial profiles of both objects are consistent with those of local spiral galaxies and are decomposed into a classic exponential disk and a central bulge. A star-forming cluster or companion galaxy as well as a compact core are detected in one of the galaxies at a redshift of 0.37+/-0.05. We discuss possible explanations for the core including a small bulge, a nuclear starburst, or an active nucleus. The same galaxy shows a peak disk surface brightness that is brighter than local disks of comparable size. These observations demonstrate the power of AO to reveal details of the morphology of distant faint galaxies and to explore galaxy evolution.Comment: 5 pages, Latex, 3 figures. Accepted for publication in P.A.S.

Drop impact upon micro- and nanostructured superhydrophobic surfaces

We experimentally investigate drop impact dynamics onto different superhydrophobic surfaces, consisting of regular polymeric micropatterns and rough carbon nanofibers, with similar static contact angles. The main control parameters are the Weber number \We and the roughness of the surface. At small \We, i.e. small impact velocity, the impact evolutions are similar for both types of substrates, exhibiting Fakir state, complete bouncing, partial rebouncing, trapping of an air bubble, jetting, and sticky vibrating water balls. At large \We, splashing impacts emerge forming several satellite droplets, which are more pronounced for the multiscale rough carbon nanofiber jungles. The results imply that the multiscale surface roughness at nanoscale plays a minor role in the impact events for small \We \apprle 120 but an important one for large \We \apprge 120. Finally, we find the effect of ambient air pressure to be negligible in the explored parameter regime \We \apprle 150Comment: 8 pages, 7 figure

Quantum-Statistical Current Correlations in Multi-Lead Chaotic Cavities

Quantum mechanics requires that identical particles are treated as indistinguishable. This requirement leads to correlations in the fluctuating properties of a system. Theoretical predictions are made for an experiment on a multi-lead chaotic quantum dot which can identify exchange effects in electronic current-current correlations. Interestingly, we find that the ensemble averaged exchange effects are of the order of the channel number, and are insensitive to dephasing.Comment: 4 pages REVTEX, including two figure

Influence of Cooled Interstellar Gas on the Fundamental Plane for Elliptical Galaxies

We explore the possibly important influence of cooled interstellar gas on the fundamental plane of elliptical galaxies. Interstellar cooling is described by a parameterized sink term in the equation of continuity. Parameters that give the best fits to the X-ray observations of NGC 4472 are used as a template for the radial distribution of interstellar cooling in structurally homologous elliptical galaxies of lower mass. Gas that cools within an effective radius can contribute an additional 10 - 30 percent to the mass of the old stellar population. If the cooled gas forms into stars of very low mass, $\ll M_{\odot}$, as is commonly assumed, the cooled mass is optically dark. As a result, the mass to light ratios determined from stellar velocities systematically overestimate that of the old stellar population. Moreover, the total mass and spatial distribution of the optically dark young stellar population does not scale homologously with galactic luminosity or radius and the total stellar mass to light ratio varies with galactic radius. We investigate the non-homologous perturbations of cooled gas on the mass to light ratio for several idealized homologous elliptical galaxies and show that they appear to be incompatible with the observed thinness of the fundamental plane. If optically luminous young stars formed from the cooled gas, the disturbance of the fundamental plane would be lessened.Comment: 10 pages with 2 figures; accepted by Astrophysical Journa

Finite voltage shot noise in normal-metal - superconductor junctions

We express the low-frequency shot noise in a disordered normal-metal - superconductor (NS) junction at finite (subgap) voltage in terms of the normal scattering amplitudes and the Andreev reflection amplitude. In the multichannel limit, the conductance exhibits resonances which are accompanied by an enhancement of the (differential) shot noise. In the study of multichannel single and double barrier junctions we discuss the noise properties of coherent transport at low versus high voltage with respect to the Andreev level spacing.Comment: 6 pages, Latex, 2 eps-figures, to be published in PRB, Appendix on Bogoliubov equation