5,188 research outputs found
Mesoscopic continuous and discrete channels for quantum information transfer
We study the possibility of realizing perfect quantum state transfer in
mesoscopic devices. We discuss the case of the Fano-Anderson model extended to
two impurities. For a channel with an infinite number of degrees of freedom, we
obtain coherent behavior in the case of strong coupling or in weak coupling
off-resonance. For a finite number of degrees of freedom, coherent behavior is
associated to weak coupling and resonance conditions
Double dot chain as a macroscopic quantum bit
We consider an array of N quantum dot pairs interacting via Coulomb
interaction between adjacent dots and hopping inside each pair. We show that at
the first order in the ratio of hopping and interaction amplitudes, the array
maps in an effective two level system with energy separation becoming
exponentially small in the macroscopic (large N) limit. Decoherence at zero
temperature is studied in the limit of weak coupling with phonons. In this case
the macroscopic limit is robust with respect to decoherence. Some possible
applications in quantum information processing are discussed.Comment: Phys. Rev. A (in press
Early use of abiraterone and radium-223 in metastatic prostate cancer
[No abstract available
Therapeutic challenges for cisplatin-resistant ovarian germ cell tumors
The majority of patients with advanced ovarian germ cell cancer are treated by cisplatin-based chemotherapy. Despite adequate first-line treatment, nearly one third of patients relapse and almost half develop cisplatin-resistant disease, which is often fatal. The treatment of cisplatin-resistant disease is challenging and prognosis remains poor. There are limited data on the efficacy of specific chemotherapeutic regimens, high-dose chemotherapy with autologous progenitor cell support and targeted therapies. The inclusion of patients in clinical trials is strongly recommended, especially in clinical trials on the most frequent male germ cell tumors, to offer wider therapeutic opportunities. Here, we provide an overview of current and potential new treatment options including combination chemotherapy, high-dose chemotherapy and molecular targeted therapies, for patients with cisplatin-resistant ovarian germ cell tumors
Second-line high-dose chemotherapy in patients with mediastinal and retroperitoneal primary non-seminomatous germ cell tumors: the EBMT experience
Background: Results of second-line chemotherapy in patients with extragonadal non-seminomatous germ cell tumor (NSGCT) appear inferior to results in testicular NSGCT. Patients with retroperitoneal NSGCT achieve a comparable long-term survival rate of 30%, but the salvage rates of patients with mediastinal primary are less than 10%. We conducted a retrospective analysis on patients with mediastinal and retroperitoneal NSGCT treated with second-line high-dose chemotherapy (HDCT) registered with the European Group for Blood and Marrow Transplantation (EBMT). Patients and methods: Between 1987 and 1999, 59 registered patients with retroperitoneal (n=37) and mediastinal (n=22) primary NSGCT, median age 28 years (range 18-60), were treated with second-line HDCT. All had received cisplatin-containing chemotherapy as first-line treatment. Results: Toxic death occurred in three cases (5%). With a median follow-up of 58 months (range 14-114), 18/59 patients (30%) continue to be disease-free. Of three patients who had a disease recurrence after HDCT, one patient achieved a disease-free status with further chemotherapy and surgery. In total, 19 patients (32%) are currently disease-free. Sixteen of 37 patients (43%) with retroperitoneal NSGCT, and three of 22 patients (14%) with mediastinal NSGCT are currently alive and disease-free. Conclusions: Second-line HDCT might represent a possible option for patients with retroperitoneal primary NSGCT. New salvage strategies are needed for patients with mediastinal NSGC
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