9,414 research outputs found
Editorial commentary: The challenge of sudden cardiac arrest in patients with structural heart disease: Still a long way to go
The sympathetic nervous system and arrhythmogenic right ventricular cardiomyopathy: Further evidence of a strong tie
Effect of ELF e.m. fields on metalloprotein redox-active sites
The peculiarity of the distribution and geometry of metallic ions in enzymes
pushed us to set the hypothesis that metallic ions in active-site act like tiny
antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+,
Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been
studied, following in vitro generation and removal of free radicals. We
observed that Superoxide radicals generation by XO is increased by a weak field
having the Larmor frequency fL of Fe2+ while the SOD1 kinetics is sensibly
reduced by exposure to a weak field having the frequency fL of Cu2+ ion.Comment: 18 pages, 4 figure
Neutrino scattering on polarized electron target and neutrino magnetic moment
The completed and proposed experiments for the measurement of the neutrino
magnetic moment are discussed. To improve the sensitivity of the search for the
neutrino magnetic moment we suggest to use a polarized electron target in the
processes of neutrino (antineutrino) -- electron scattering. It is shown that
in this case the weak interaction term in the total cross section is few times
smaller comparing with unpolarized case, but the electromagnetic term does not
depend on electron polarization.Comment: 12 pages, 7 figures. Talk given at the XXVIII ITEP Winter School of
Physics, Snegiri, Russia, February 22 - March 1, 200
Análise quÃmica do solo e produtividade do algodoeiro em resposta a doses de nitrogênio e plantas de cobertura no perÃodo de inverno.
CSL-1: a chance projection effect or serendipitous discovery of a gravitational lens induced by a cosmic string?
CSL-1 (Capodimonte--Sternberg--Lens Candidate, No.1) is an extragalactic
double source detected in the OAC-DF (Osservatorio Astronomico di Capodimonte -
Deep Field). It can be interpreted either as the chance alignment of two
identical galaxies at z=0.46 or as the first case of gravitational lensing by a
cosmic string. Extensive modeling shows in fact that cosmic strings are the
only type of lens which (at least at low angular resolution) can produce
undistorted double images of a background source. We propose an experimentum
crucis to disentangle between these two possible explanations. If the lensing
by a cosmic string should be confirmed, it would provide the first measurements
of energy scale of symmetry breaking and of the energy scale of Grand Unified
Theory (GUT).Comment: Accepted for publication in the Mon. Not. Royal Astron. Societ
Drug-eluting compared to bare metal stents in patients with end-stage renal disease on dialysis: A meta-analysis
Topological Entanglement of Polymers and Chern-Simons Field Theory
In recent times some interesting field theoretical descriptions of the
statistical mechanics of entangling polymers have been proposed by various
authors. In these approaches, a single test polymer fluctuating in a background
of static polymers or in a lattice of obstacles is considered. The extension to
the case in which the configurations of two or more polymers become non-static
is not straightforward unless their trajectories are severely constrained. In
this paper we present another approach, based on Chern--Simons field theory,
which is able to describe the topological entanglements of two fluctuating
polymers in terms of gauge fields and second quantized replica fields.Comment: 16 pages, corrected some typos, added two new reference
IART® (Intra-Operative Avidination for Radionuclide Therapy) for accelerated radiotherapy in breast cancer patients. Technical aspects and preliminary results of a phase II study with 90Y-labelled biotin
Background: Breast conserving surgery (BCS) plus external beam radiotherapy (EBRT) is considered the standard treatment for early breast cancer. We have investigated the possibility of irradiating the residual gland, using an innovative nuclear medicine approach named IART® (Intra-operative Avidination for Radionuclide Therapy). Aim: The objective of this study was to determine the optimal dose of avidin with a fixed activity (3.7 GBq) of 90Y-biotin, in order to provide a boost of 20 Gy, followed by EBRT to the whole breast (WB) at the reduced dose of 40 Gy. Local and systemic toxicity, patient's quality of life, including the cosmetic results after the combined treatment with IART® and EBRT, were assessed. Methods: After tumour excision, the surgeon injected native avidin diluted in 30 ml of saline solution into and around the tumour bed (see video). Patients received one of three avidin dose levels: 50 mg (10 pts), 100 mg (15 pts) and 150 mg (10 pts). Between 12 to 24 h after surgery, 3.7 GBq 90Y-biotin spiked with 185 MBq 111In-biotin was administered intravenously (i.v.). Whole body scans and SPECT images were performed up to 30 h post-injection for dosimetric purposes. WB-EBRT was administered four weeks after the IART® boost. Local toxicity and quality of life were evaluated. Results: Thirty-five patients were evaluated. No side effects were observed after avidin administration and 90Y-biotin infusion. An avidin dose level of 100 mg resulted the most appropriate in order to deliver the required radiation dose (19.5 + 4.0 Gy) to the surgical bed. At the end of IART®, no local toxicity occurred and the overall cosmetic result was good. The tolerance to the reduced EBRT was also good. The highest grade of transient local toxicity was G3, which occurred in 3/32 pts following the completion of WB-EBRT. The combination of IART® +EBRT was well accepted by the patients, without any changes to their quality of life. Conclusions: These preliminary results support the hypothesis that IART® may represent a valid approach to accelerated WB irradiation after BCS. We hope that this nuclear medicine technique will contribute to a better management of breast cancer patients. © the authors; licensee ecancermedicalscience
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