Indirect Sensitivity to Heavy Z' Bosons at a Multi-TeV e+e- Collider

We compare the phenomenology of two models, the so-called minimal Z' and an effective model for a SM-like Higgs realised as a composite state of a new strong interaction, at a multi-TeV linear collider in the hypothesis that the new physics is at a scale beyond the direct reach of the machine.Comment: 6 pages, 5 figures, to appear in the Proceedings of the International Workshop on Future Linear Colliders LCWS201

Probing New Scales at a e+e- Linear Collider

Extending the sensitivity to New Physics beyond the anticipated reach of the LHC is a prime aim of future colliders. This paper summarises the potential of an e+e- linear collider, at and beyond 1 TeV, using a realistic simulation of the detector response and the accelerator induced background. The possible LC energy-luminosity trade-offs offered in probing multi-TeV scales for new phenomena with electro-weak observables are also discussed

Effect of different lignocellulosic fibres on poly(ε-caprolactone)-based composites for potential applications in orthotics

This work compares the mechanical and thermal behaviour of fully biodegradable biocomposites based on polycaprolactone reinforced with three different natural fibres, namely hemp, sisal and coir, for potential applications in the field of orthoses. The same properties were further compared to those of two commercially available materials commonly used in the same prospective field. The results confirmed that the addition of natural fibres, irrespective of the origin of the fibres (leaf, bast or fruit) to a biodegradable matrix allows for significant improvement of the mechanical behaviour of the ensuing composites compared to traditional thermoplastic materials used in orthotics

Room temperature Bloch surface wave polaritons

Polaritons are hybrid light-matter quasi-particles that have gathered a significant attention for their capability to show room temperature and out-of-equilibrium Bose-Einstein condensation. More recently, a novel class of ultrafast optical devices have been realized by using flows of polariton fluids, such as switches, interferometers and logical gates. However, polariton lifetimes and propagation distance are strongly limited by photon losses and accessible in-plane momenta in usual microcavity samples. In this work, we show experimental evidence of the formation of room temperature propagating polariton states arising from the strong coupling between organic excitons and a Bloch surface wave. This result, which was only recently predicted, paves the way for the realization of polariton devices that could allow lossless propagation up to macroscopic distances

On the Complementarity of Higgs and Radion Searches at LHC

Models with 3-branes in extra dimensions typically imply the existence of a radion, phi that can mix with the Higgs, h, thereby modifying the Higgs properties and the prospects for its detectability at the LHC. The presence of the phi will extend the scope of the LHC searches. Detection of both the phi and the h might be possible. In this paper, we study the complementarity of the observation of gg -> h, with h -> gamma gamma or h -> ZZ -> 4 leptons, and gg -> phi -> ZZ -> 4 leptons at the LHC in the context of the Randall-Sundrum model. The potential for determining the nature of the detected scalar(s) at the LHC and at an e+e- linear collider is discussed, both separately and in combination.Comment: 11 pages, 5 figure

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2.

CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue. The anti-inflammatory COX2 inhibitor celecoxib has been utilized as anti-tumour drug due to its anti-proliferative activity. However, its effects in hematological malignancies, in particular CML, have not been investigated yet. Thus, we tested biological effects and mechanisms of action of celecoxib in Philadelphia-positive (Ph+) CML and ALL cells.We show here that celecoxib suppresses the growth of Ph+ cell lines by increasing G1-phase and apoptotic cells and reducing S- and G2-phase cells. These effects were independent of COX2 inhibition but required the rapid activation of AMP-activated protein kinase (AMPK) and the consequent inhibition mTORC1 and 2. Treatment with celecoxib also restored GSK3β function and led to down-regulation of β-catenin activity through transcriptional and post-translational mechanisms, two effects likely to contribute to Ph+ cell growth suppression by celecoxib.Celecoxib inhibited colony formation of TKI-resistant Ph+ cell lines including those with the T315I BCR-ABL mutation and acted synergistically with imatinib in suppressing colony formation of TKI-sensitive Ph+ cell lines. Finally, it suppressed colony formation of CD34+ cells from CML patients, while sparing most CD34+ progenitors from healthy donors, and induced apoptosis of primary Ph+ ALL cells.Together, these findings indicate that celecoxib may serve as a COX2-independent lead compound to simultaneously target the mTOR and β-catenin pathways, key players in the resistance of CML stem cells to TKIs

Targeting CDK6 and BCL2 Exploits the MYB Addiction of Ph+ Acute Lymphoblastic Leukemia

Philadelphia chromosome–positive acute lymphoblastic leukemia (Phþ ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with chemotherapy. However, most patients develop resistance to TKI through BCR-ABL1–dependent and –independent mechanisms. Newly developed TKI can target Phþ ALL cells with BCR-ABL1–dependent resistance; however, overcoming BCR-ABL1–independent mechanisms of resistance remains challenging because transcription factors, which are difficult to inhibit, are often involved. We show here that (i) the growth of Phþ ALL cell lines and primary cells is highly dependent on MYB-mediated transcriptional upregulation of CDK6, cyclin D3, and BCL2, and (ii) restoring their expression in MYB-silenced Phþ ALL cells rescues their impaired proliferation and survival. Levels of MYB and CDK6 were highly correlated in adult Phþ ALL (P ¼ 0.00008). Moreover, Phþ ALL cells exhibited a specific requirement for CDK6 but not CDK4 expression, most likely because, in these cells, CDK6 was predominantly localized in the nucleus, whereas CDK4 was almost exclusively cytoplasmic. Consistent with their essential role in Phþ ALL, pharmacologic inhibition of CDK6 and BCL2 markedly suppressed proliferation, colony formation, and survival of Phþ ALL cells ex vivo and in mice. In summary, these findings provide a proof-of-principle, rational strategy to target the MYB addiction of Phþ ALL. © 2017 American Association for Cancer Research