39 research outputs found

    A Point of View: In Praise of the Zoo

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    A Point of View: In Praise of the Zoo

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    Do we have free will or are we predetermined?

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    The question of whether we are fundamentally free or determined in our thoughts and actions has been in the middle of philosophical debate for many centuries. A film directed and animated by Rachel Lillie, commissioned by The School of Life, written by Alain de Botton

    The cost of child abuse in Australia

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    The Australian Childhood Foundation and Child Abuse Prevention Research Australia at Monash University commissioned Access Economics and collaborated with them to estimate the cost of child abuse (physical, sexual and emotional abuse, neglect and being forced to live with family violence). Two different types of costs were calculated using two separate approaches. The calculations made throughout the report have been chosen specifically to be inherently conservative in order to ensure that final results are not inflated or disputable.  Authors: Taylor, P., Moore, P., Pezzullo, L., Tucci, J., Goddard, C. and De Bortoli, L

    Globalisation vs. a simple life

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    Whitney Fitzsimmons speaks to author Alain de Botton, about globalisation, its effects and how it impacts the way we live

    Chromosomal minimal critical regions in therapy-related leukemia appear different from those of de novo leukemia by high-resolution aCGH.

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    Therapy-related acute leukemia (t-AML), is a severe complication of cytotoxic therapy used for primary cancer treatment. The outcome of these patients is poor, compared to people who develop de novo acute leukemia (p-AML). Cytogenetic abnormalities in t-AML are similar to those found in p-AML but present more frequent unfavorable karyotypes depending on the inducting agent. Losses of chromosome 5 or 7 are observed after alkylating agents while balanced translocations are found after topoisomerase II inhibitors. This study compared t-AML to p-AML using high resolution array CGH in order to find copy number abnormalities (CNA) at a higher resolution than conventional cytogenetics. More CNAs were observed in 30 t-AML than in 36 p-AML: 104 CNAs were observed with 63 losses and 41 gains (mean number 3.46 per case) in t-AML, while in p-AML, 69 CNAs were observed with 32 losses and 37 gains (mean number of 1.9 per case). In primary leukemia with a previously "normal" karyotype, 18% exhibited a previously undetected CNA, whereas in the (few) t-AML with a normal karyotype, the rate was 50%. Several minimal critical regions (MCRs) were found in t-AML and p-AML. No common MCRs were found in the two groups. In t-AML a 40 kb deleted MCR pointed to RUNX1 on 21q22, a gene coding for a transcription factor implicated in frequent rearrangements in leukemia and in familial thrombocytopenia. In de novo AML, a 1 Mb MCR harboring ERG and ETS2 was observed from patients with complex aCGH profiles. High resolution cytogenomics obtained by aCGH and similar techniques already published allowed us to characterize numerous non random chromosome abnormalities. This work supports the hypothesis that they can be classified into several categories: abnormalities common to all AML; those more frequently found in t-AML and those specifically found in p-AML
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