Prayer and subjective well-being : the application of a cognitive-behavioural framework

The aim of the present study was to examine the relationship between a model of prayer and a measure of subjective well-being within the context of a cognitive-behavioural framework. A community sample of 173 (77 males and 96 females) British adults completed measures of prayer activity and the General Health Questionnaire-28. The present findings suggest that meditative prayer, frequency of prayer, and prayer experience account for unique variance (among other measures of prayer) in a general measure of subjective well-being. The results demonstrate the potential usefulness of a cognitive-behavioural framework to help better understand the relationship between prayer and subjective well-being

Adolescence: The importance of the peer group and friendship

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis is concerned with the nature of the peer group experience and friendship patterns amongst a sample of 3rd, 4th and 5th year secondary school pupils. The thesis has four parts and a General Introduction in which the need for more sociological research in the area of the peer group and friendship is asserted. Certain themes are developed in relation to the peer group and friendship, and arguments for the research established. In the final part of the General Introduction consideration is given to the nature of the sociology of youth in relation to social class and age grading in society. Part One has three Chapters. The first deals with recent research into the peer group, most of which is American in origin with the exception of certain ethnographic studies which have been published in this country over the last few years. In Chapter Two research into friendship is considered with Chapter Three providing a critical evaluation of the research presented. A general schema is provided, drawing on the literature review which provides the basis for the development of research methods and the subsequent research programme. Part Two establishes the basis for the thesis research and has one chapter. Four objectives are explored. The first concerns the importance of friendship to young people, the second with levels of friendship, the third with deriving definitions of friendship. The final objective examines the effects of age and sex on friendship and is compared with the findings from four significant studies undertaken in this area. Sociometry is considered in relation to "mapping" a group, a self esteem inventory is developed and the Higher Schools Personality Questionnaire evaluated with a view to measuring a number of personality traits. In Chapter Five of Part Three a research design for quantitative and qualitative research is presented. The data are presented in Chapters Six and Seven. 371 young people completed a questionnaire into their friendship and peer relations and two peer groups were intensively involved in group discussion in an endeavour to provide more detailed information on friendship and peer activities. The final part, Chapter Eight, is devoted to a detailed consideration of the findings from the research in the light of the established objectives. An appraisal is undertaken of the extent to which new knowledge has been provided in the social sciences regarding the peer group and friendship

Lettering in ornament : an inquiry into the decorative use of lettering, past, present and posible

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 2016Fecha en la nota a la 2 ed. en p. [V]: 191

Religion and health : the application of a cognitive-behavioural framework

The empirical examination of the relationship between religion and health has often lacked theoretical direction. The aim of the study was to examine the relationship between dimensions of religiosity and health within the context of James and Wells’ cognitive-behavioural framework of religion. A community sample of 177 UK adults completed measures of religious orientation, religious coping, and prayer activity alongside the SF-36 Health Survey. Consistent with the cognitive-behavioural framework of religion, intrinsic religiosity and meditative prayer scores accounted for unique variance in both physical and mental health scores over a number of religious measures. These findings suggest the potential usefulness and importance of a cognitive-behavioural framework to understand the relationship between religion (as measured by meditative prayer and intrinsic religiosity) and health

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma.

Because many patients with unresectable basal cell carcinoma (BCC) are aged ≥65 years, this study explores the efficacy and safety of vismodegib in these patients with locally advanced (la) or metastatic (m) basal cell carcinoma (BCC) in the ERIVANCE BCC trial and the expanded access study (EAS).We compared patients aged ≥65 years to patients aged <65 years taking vismodegib 150 mg/day, using descriptive statistics for response and safety. Patients aged ≥65 years (laBCC/mBCC) were enrolled in ERIVANCE BCC (33/14) and EAS (27/26). Investigator-assessed best overall response rate in patients ≥65 and <65 years was 46.7%/35.7% and 72.7%/52.6% (laBCC/mBCC), respectively, in ERIVANCE BCC and 45.8%/33.3% and 46.9%/28.6%, respectively, in EAS. These differences were not clinically meaningful. Safety was similar in both groups, although those aged ≥65 years had a higher percentage of grade 3-5 adverse events than those aged <65 years. Vismodegib demonstrated similar clinical activity and adverse events regardless of age

What factors determine placental glucose transfer kinetics?

Introduction: transfer of glucose across the human placenta is directly proportional to maternal glucose concentrations even when these are well above the physiological range. This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta.Methods: transfer of d-glucose, 3H-3-o-methyl-d-glucose (3H-3MG) and 14C-l-glucose across the isolated perfused human placental cotyledon was determined for maternal and fetal arterial d-glucose concentrations between 0 and 20 mmol/l.Results: clearance of 3H-3MG or 14C-l-glucose was not affected by maternal or fetal d-glucose concentrations in either circulation.Discussion: based on the arterial glucose concentrations and the reported KM for GLUT1, the transfer of d-glucose and 3H-3MG would be expected to show signs of saturation as d-glucose concentrations increased but this did not occur. One explanation for this is that incomplete mixing of maternal blood and the rate of diffusion across unstirred layers may lower the effective concentration of glucose at the microvillous membrane and subsequently at the basal membrane. Uncertainties about the affinity of GLUT1 for glucose, both outside and inside the cell, may also contribute to the difference between the predicted and observed kinetics.Conclusion: these factors may therefore help explain why the observed and predicted kinetics differ and they emphasise the importance of understanding the function of transport proteins in their physiological context. The development of a computational model of glucose transfer may improve our understanding of how the determinants of placental glucose transfer interact and function as a syste

Direct and mediated effects of a social-emotional and character development program on adolescent substance use

Mitigating and preventing substance use among adolescents requires approaches that address the multitude of factors that influence this behavior. Such approaches must be tested, not only for evidence of empirical effectiveness, but also to determine the mechanisms by which they are successful. The aims of the present study were twofold: 1) To determine the effectiveness of a school-based social-emotional and character development (SECD) program, Positive Action (PA), in reducing substance use (SU) among a sample of U.S. youth living in a low-income, urban environment, and 2) to test one mechanism by which the program achieves its success. We used longitudinal mediation analysis to test the hypotheses that: 1) students attending PA intervention schools engage in significantly less SU than students attending control schools, 2) students attending PA intervention schools show significantly better change in SECD than students attending control schools, and 3) the effect of the PA intervention on SU is mediated by the change in SECD. Analyses revealed program effects on both SECD and SU, a relationship between SECD and SU, and the effects of PA on SU were completely mediated by changes in SECD. Future research directions and implications for schoolbased social-emotional and character development efforts and substance use prevention are addressed.peer-reviewe

Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis

N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors important for synaptic plasticity, memory, and neuropsychiatric health. NMDAR hypofunction contributes to multiple disorders, including anti-NMDAR encephalitis (NMDARE), an autoimmune disease of the CNS associated with GluN1 antibody-mediated NMDAR internalization. Here we characterize the functional/pharmacological consequences of exposure to CSF from female human NMDARE patients on NMDAR function, and we characterize the effects of intervention with recently described positive allosteric modulators (PAMs) of NMDARs. Incubation (48 h) of rat hippocampal neurons of both sexes in confirmed NMDARE patient CSF, but not control CSF, attenuated NMDA-induced current. Residual NMDAR function was characterized by lack of change in channel open probability, indiscriminate loss of synaptic and extrasynaptic NMDARs, and indiscriminate loss of GluN2B-containing and GluN2B-lacking NMDARs. NMDARs tagged with N-terminal pHluorin fluorescence demonstrated loss of surface receptors. Thus, function of residual NMDARs following CSF exposure was indistinguishable from baseline, and deficits appear wholly accounted for by receptor loss. Coapplication of CSF and PAMs of NMDARs (SGE-301 or SGE-550, oxysterol-mimetic) for 24 h restored NMDAR function following 24 h incubation in patient CSF. Curiously, restoration of NMDAR function was observed despite washout of PAMs before electrophysiological recordings. Subsequent experiments suggested that residual allosteric potentiation of NMDAR function explained the persistent rescue. Further studies of the pathogenesis of NMDARE and intervention with PAMs may inform new treatments for NMDARE and other disorders associated with NMDAR hypofunction.SIGNIFICANCE STATEMENTAnti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is increasingly recognized as an important cause of sudden-onset psychosis and other neuropsychiatric symptoms. Current treatment leaves unmet medical need. Here we demonstrate cellular evidence that newly identified positive allosteric modulators of NMDAR function may be a viable therapeutic strategy.</jats:p