Pressure-driven flow of solid helium

The recent torsional oscillator results of Kim and Chan suggest a supersolid phase transition in solid 4He. We have used a piezoelectrically driven diaphragm to study the flow of solid helium through an array of capillaries. Our measurements showed no indication of low temperature flow, placing stringent restrictions on supersolid flow in response to a pressure difference. The average flow speed at low temperatures was less than 1.2x10-14 m/s, corresponding to a supersolid velocity at least 7 orders of magnitude smaller than the critical velocities inferred from the torsional oscillator measurements.Comment: 4 pages, 3 figure

Beyond Critical Period Learning: Striatal FoxP2 Affects the Active Maintenance of Learned Vocalizations in Adulthood.

In humans, mutations in the transcription factor forkhead box P2 (FOXP2) result in language disorders associated with altered striatal structure. Like speech, birdsong is learned through social interactions during maturational critical periods, and it relies on auditory feedback during initial learning and on-going maintenance. Hearing loss causes learned vocalizations to deteriorate in adult humans and songbirds. In the adult songbird brain, most FoxP2-enriched regions (e.g., cortex, thalamus) show a static expression level, but in the striatal song control nucleus, area X, FoxP2 is regulated by singing and social context: when juveniles and adults sing alone, its levels drop, and songs are more variable. When males sing to females, FoxP2 levels remain high, and songs are relatively stable: this "on-line" regulation implicates FoxP2 in ongoing vocal processes, but its role in the auditory-based maintenance of learned vocalization has not been examined. To test this, we overexpressed FoxP2 in both hearing and deafened adult zebra finches and assessed effects on song sung alone versus songs directed to females. In intact birds singing alone, no changes were detected between songs of males expressing FoxP2 or a GFP construct in area X, consistent with the marked stability of mature song in this species. In contrast, songs of males overexpressing FoxP2 became more variable and were less preferable to females, unlike responses to songs of GFP-expressing control males. In deafened birds, song deteriorated more rapidly following FoxP2 overexpression relative to GFP controls. Together, these experiments suggest that behavior-driven FoxP2 expression and auditory feedback interact to precisely maintain learned vocalizations

A fiber-optic current sensor for aerospace applications

A robust, accurate, broad-band, alternating current sensor using fiber optics is being developed for space applications at power frequencies as high as 20 kHz. It can also be used in low and high voltage 60 Hz terrestrial power systems and in 400 Hz aircraft systems. It is intrinsically electromagnetic interference (EMI) immune and has the added benefit of excellent isolation. The sensor uses the Faraday effect in optical fiber and standard polarimetric measurements to sense electrical current. The primary component of the sensor is a specially treated coil of single-mode optical fiber, through which the current carrying conductor passes. Improved precision is accomplished by temperature compensation by means of signals from a novel fiber-optic temperature sensor embedded in the sensing head. The technology contained in the sensor is examined and the results of precision tests conducted at various temperatures within the wide operating range are given. The results of early EMI tests are also given

Fiber-optic sensors for aerospace electrical measurements: An update

Fiber-optic sensors are being developed for electrical current, voltage, and power measurements in aerospace applications. These sensors are presently designed to cover ac frequencies from 60 Hz to 20 kHz. The current sensor, based on the Faraday effect in optical fiber, is in advanced development after some initial testing. Concentration is on packaging methods and ways to maintain consistent sensitivity with changes in temperature. The voltage sensor, utilizing the Pockels effect in a crystal, has excelled in temperature tests. This paper reports on the development of these sensors, the results of evaluation, improvements now in progress, and the future direction of the work

Multiplexable Kinetic Inductance Detectors

We are starting to investigate a novel multiplexable readout method that can be applied to a large class of superconducting pair-breaking detectors. This readout method is completely different from those currently used with STJ and TES detectors, and in principle could deliver large pixel counts, high sensitivity, and Fano-limited spectral resolution. The readout is based on the fact that the kinetic surface inductance L_s of a superconductor is a function of the density of quasiparticles n, even at temperatures far below T_c. An efficient way to measure changes in the kinetic inductance is to monitor the transmission phase of a resonant circuit. By working at microwave frequencies and using thin films, the kinetic inductance can be a significant part of the total inductance L, and the volume of the inductor can be made quite small, on the order of 1 µm^3. As is done with other superconducting detectors, trapping could be used to concentrate the quasiparticles into the small volume of the inductor. However, the most intriguing aspect of the concept is that passive frequency multiplexing could be used to read out ~10^3 detectors with a single HEMT amplifier

Topological entropy of realistic quantum Hall wave functions

The entanglement entropy of the incompressible states of a realistic quantum Hall system are studied by direct diagonalization. The subdominant term to the area law, the topological entanglement entropy, which is believed to carry information about topologic order in the ground state, was extracted for filling factors 1/3, 1/5 and 5/2. The results for 1/3 and 1/5 are consistent with the topological entanglement entropy for the Laughlin wave function. The 5/2 state exhibits a topological entanglement entropy consistent with the Moore-Read wave function.Comment: 6 pages, 6 figures; improved computations and graphics; added reference

Control System for the LEDA 6.7-MeV Proton Beam Halo Experiment

Measurement of high-power proton beam-halo formation is the ongoing scientific experiment for the Low Energy Demonstration Accelerator (LEDA) facility. To attain this measurement goal, a 52-magnet beam line containing several types of beam diagnostic instrumentation is being installed. The Experimental Physics and Industrial Control System (EPICS) and commercial software applications are presently being integrated to provide a real-time, synchronous data acquisition and control system. This system is comprised of magnet control, vacuum control, motor control, data acquisition, and data analysis. Unique requirements led to the development and integration of customized software and hardware. EPICS real-time databases, Interactive Data Language (IDL) programs, LabVIEW Virtual Instruments (VI), and State Notation Language (SNL) sequences are hosted on VXI, PC, and UNIX-based platforms which interact using the EPICS Channel Access (CA) communication protocol. Acquisition and control hardware technology ranges from DSP-based diagnostic instrumentation to the PLC-controlled vacuum system. This paper describes the control system hardware and software design, and implementation.Comment: LINAC2000 Conference, 4 pg

Association between MAPT polymorphism but not APOE promoter and elite rugby athlete status

INTRODUCTION: Incidence and outcomes of concussions have been hypothesised to be genetically influenced. The APOE Promoter G219T (rs405509) polymorphism has been associated with differential promoter activity and unfavourable outcomes after traumatic brain injury. The TT genotype is associated with a 3-fold greater risk of multiple concussions. The TT genotype of MAPT (rs10445337) has also been associated with poorer outcomes after concussion. Rugby has one of the highest incidences of concussion in sport, so it was hypothesised that APOE Promoter TT and MAPT TT genotypes would be less prevalent in elite rugby athletes because those genotypes, previously associated with increased risk, would be less compatible with achieving elite athlete status. METHODS: Participants were from the RugbyGene project, comprising elite Caucasian male rugby athletes (n = 528; mean (standard deviation) height 1.85 (0.07) m, mass 101 (14) kg, age 29 (7) yr), including 420 rugby union (RU) athletes that for some analyses were divided into forwards and backs and 108 rugby league (RL) athletes. Non-athletes were 592 Caucasian men and women (57% male, height 1.72 (0.10) m, mass 74 (14) kg, age 31 (7) yr). PCR of genomic DNA was used to determine genotypes using TaqMan probes, then groups were compared using χ2 and odds ratio (OR) statistics. RESULTS: All genotype data were in Hardy-Weinberg equilibrium. For MAPT (rs10445337), the risk genotype (TT) was underrepresented in rugby athletes (60%) compared to non-athletes (66%), CT more common in rugby athletes (34%) than non-athletes (29%) and little difference in CC genotype frequencies (χ2 = 7.092, P = 0.029; TT genotype frequency OR = 0.80, 95% confidence intervals (CI) = 0.62-1.02). There were no differences in MAPT (rs10445337) genotype frequencies between RU forwards and backs. For APOE Promoter G219T (rs405509), there were no differences in genotype frequencies between all athletes (RU and RL) and non-athletes (27% TT genotype in players and non-athletes), nor between RU forwards and backs. CONCLUSION: The MAPT (rs10445337) TT genotype is 6% less common in elite rugby athletes than non-athletes. Therefore, carrying at least one rs10445337 C allele appears to increase the probability of sustained career success in the high-risk concussion environment of elite rugby, perhaps via a greater ability to recover from concussions.Peer reviewe

Temperature dependence of the frequency and noise of superconducting coplanar waveguide resonators

We present measurements of the temperature and power dependence of the resonance frequency and frequency noise of superconducting niobium thin-film coplanar waveguide resonators carried out at temperatures well below the superconducting transition (Tc=9.2 K). The noise decreases by nearly two orders of magnitude as the temperature is increased from 120 to 1200 mK, while the variation of the resonance frequency with temperature over this range agrees well with the standard two-level system (TLS) model for amorphous dielectrics. These results support the hypothesis that TLSs are responsible for the noise in superconducting microresonators and have important implications for resonator applications such as qubits and photon detectors

Association of MMP3 but not TIMP2 gene variants with elite rugby player status and rugby code

Introduction: Achilles tendon pathology and anterior cruciate ligament rupture are multifactorial conditions for which genetic risk factors have been identified. Single nucleotide polymorphisms (SNPs) within the MMP3 (rs591058, rs679620, rs650108) and TIMP2 (rs4789932) genes have previously been associated with tendon and ligament pathologies. Although not entirely clear, prior literature indicates the risk alleles for Achilles tendon pathology as T (rs591058), G (rs679620) and A (rs650108) for MMP3. However, prior evidence regarding TIMP2 is equivocal. MMP3 is considered an essential regulator of matrix degradation and remodelling within diseased and normal musculoskeletal soft tissues. TIMP2 maintains homeostasis in the extracellular matrix in part by inhibiting MMP function. Given the high incidence and severity of tendon and ligament injuries in elite rugby athletes, we hypothesised that the aforementioned SNPs would be associated with career success. Methods: Participants from the RugbyGene project were elite Caucasian male rugby athletes (n = 566; mean (standard deviation) height 1.85 (0.07) m, mass 101 (14) kg, age 29 (7) yr), including 420 rugby union (RU) athletes that for some analyses were divided into forwards and backs and 120 rugby league (RL) athletes. Non-athletes were 589 Caucasian men and women (n = 589, 57% male, height 1.72 (0.10) m, mass 74 (14) kg, age 31 (7) yr). PCR of genomic DNA was used to determine genotypes using TaqMan probes, then groups were compared using Χ2 and odds ratio (OR) statistics. Results: As hypothesized, the MMP3 rs591058 risk genotype (TT) was less frequent in rugby athletes (28%) compared to non-athletes (33%) (Χ2 = 7.265, P = 0.026; OR = 1.18, 95% confidence intervals (CI) = 0.86-1.63). No differences were found for MMP3 rs679620, rs650108 or TIMP2 rs4789932 between rugby athletes and non-athletes. When RL athletes were compared to non-athletes, the risk genotype (TT) of MMP3 rs591058 was underrepresented in RL athletes (19%) compared to non-athletes (33%). The MMP3 rs679620 ‘protective’ allele (C) was more frequent in RL athletes (55%) compared to non-athletes (48%) (OR = 1.3, 95% CI = 0.98-1.74). However, for MMP3 rs650108 the ‘risk’ allele (A) was overrepresented in RL athletes (32%) compared to non-athletes (26%). There were no genotype differences for any gene variant between RU athletes and non-athletes. The ‘risk’ allele (T) of the MMP3 rs679629 polymorphism and the ‘protective’ allele (G) of the MMP3 rs650108 polymorphism were less common in RL (45%, 68%, respectively) than RU athletes (54%, 76%, respectively). Conclusion: We provide evidence for elite rugby athletes possessing a protective genetic profile regarding tendon and ligament injury risk. Notably, a less frequent rs591058 TT genotype in athletes suggests a lower risk of injury could therefore enhance career success in rugby. Furthermore, RL players appear to have differing genetic characteristics compared to their RU counterparts, which might reflect some differences in physiological demands between codes.Peer reviewedFinal Published versio