The influence of altitude on the anaerobic and aerobic capacities of men in work Final scientific report

Altitude influence on anaerobic and aerobic capacities of working me

Faculty Stress Factors at a Public University During the COVID-19 Pandemic

Emergency Remote Teaching (ERT) during the COVID-19 pandemic brought many challenges to education systems across the world. Faculty at a public university participated in a survey to aid in defining challenges and stress factors experienced with ERT. Eighty-three percent of faculty participating in the survey indicated they were stressed during the pandemic ERT. Linked stress factors included course organization satisfaction, capturing student learning, energy to move to an online format, translating lessons to online, and online teaching experience. Open-ended survey questions additionally identified faculty frustrations from the lack of student engagement, the amount of time to move to the ERT format, and the desire to decrease student enrollment numbers in courses when teaching in the online format. Clemson University gave faculty the option of utilizing a hybrid model of ERT course delivery during the pandemic, rotating students enrolled in a course for in-person class attendance during a portion of the semester, and this model appeared to elevate some of the issues related to student engagement

Impact of Emergency Remote Teaching on University Students at a Public Institution in the United States

The educational experiences of university students participating in Emergency Remote Teaching (ERT) during the COVID-19 pandemic were evaluated using a survey instrument. Students found ERT stressful (89%) and indicated challenges from inadequate internet (91%), lack of privacy (45%), and increased amount of studying (3 hours more per week). Academic rank correlated with stress level during ERT, with freshmen (42%) reporting the highest stress level and seniors (48%) reporting minimal stress. Lack of faceto-face instruction, missing peer interaction and having to teach the course material to themselves were the top issues that students disliked with ERT. Respondents recognized the need for organization, selfmotivation, and increased interaction with other students and instructors as key factors for effectiveness and satisfaction of ERT instruction

Hypertension, retinopathy, and acute kidney injury in dogs: A prospective study

Background Systemic hypertension (SH) is a potential complication of acute kidney injury (AKI) in dogs. Objective To describe the prevalence of SH and hypertensive retinopathy in dogs with AKI, to investigate the relationship between SH and severity of AKI and to assess possible factors associated with SH. Animals Fifty‐two dogs with AKI. Methods Prospective observational study of dogs presenting to a tertiary referral center that fulfilled the International Renal Interest Society (IRIS) guidelines for the diagnosis of AKI. Systolic blood pressure measurement, urine protein/creatinine ratio (UPCR), urine output, presence of hypertensive retinopathy and fluid overload (FO), survival to discharge and duration of hospitalization were subsequently assessed. The prevalence of SH was calculated and the relationship between SH and recorded factors was examined by nonparametric statistics. Results The prevalence of SH (≥160 mm Hg) on admission or during hospitalization was 75% (39/52) and in 56% (22/39) of cases this was severe (≥180 mm Hg). Sixteen percent (7/43) of dogs had evidence of hypertensive retinopathy and 77% (24/31) dogs had UPCR >0.5. Forty‐two percent (22/52) dogs had FO on admission or during hospitalization. There was no association between SH and IRIS AKI grade, oligo/anuria, survival to discharge, duration of hospitalization or proteinuria. Dogs with FO on presentation were more likely to be hypertensive at admission compared to dogs without FO (P = .02). Dogs that did not survive to discharge were more likely to have FO (P = .007). Conclusions and Clinical Importance Systemic hypertension is common in dogs with AKI. Systemic hypertension might be associated with FO, which itself is associated with nonsurvival. Monitoring for SH and FO is therefore warranted in dogs with AKI

AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory. We have previously shown that Thorase plays an important role in the internalization of AMPARs from the synaptic membrane. Here, we show that N-methyl-d-aspartate receptor (NMDAR) activation leads to increased S-nitrosylation of Thorase and N-ethylmaleimide-sensitive factor (NSF). S-nitrosylation of Thorase stabilizes Thorase-AMPAR complexes and enhances the internalization of AMPAR and interaction with protein-interacting C kinase 1 (PICK1). S-nitrosylated NSF is dependent on the S-nitrosylation of Thorase via trans-nitrosylation, which modulates the surface insertion of AMPARs. In the presence of the S-nitrosylation-deficient C137L Thorase mutant, AMPAR trafficking, long-term potentiation, and long-term depression are impaired. Overall, our data suggest that both S-nitrosylation and interactions of Thorase and NSF/PICK1 are required to modulate AMPAR-mediated synaptic plasticity. This study provides critical information that elucidates the mechanism underlying Thorase and NSF-mediated trafficking of AMPAR complexes

Technical note: Creating a four‐dimensional model of the liver using finite element analysis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134997/1/mp5055.pd

Star polymers: A study of the structural arrest in presence of attractive interactions

Simulations and Mode-Coupling Theory calculations, for a large range of the arm number $f$ and packing fraction $\eta$ have shown that the structural arrest and the dynamics of star polymers in a good solvent are extremely rich: the systems show a reentrant melting of the disordered glass nested between two stable fluid phases that strongly resemble the equilibrium phase diagram. Starting from a simple model potential we investigate the effect of the interplay between attractive interactions of different range and ultrasoft core repulsion, on the dynamics and on the occurrence of the ideal glass transition line. In the two cases considered so far, we observed some significant differences with respect to the purely repulsive pair interaction. We also discuss the interplay between equilibrium and non equilibrium phase behavior. The accuracy of the theoretical tools we utilized in our investigation has been checked by comparing the results with molecular dynamics simulations.Comment: 24 pages, 14 figures, accepted for publication in Physical Review

Construction of the Soudan 2 detector

Progress in the construction of the Soudan 2 nucleon decay detector which is being built at the Soudan iron mine in Minnesota is discussed. The expected event rate and characteristics of low energy neutrino events, muon events, multiple muon events, and other cosmic ray phenomena are discussed