Evaluation of the effect of type II diabetes mellitus on Bone Mineral Density of Upper and Lower Limbs by Dual-Energy X-Ray Absorptiometry

Background: Bone mineral density has been assessed using Dual-Energy X-Ray Absorptiometry. Bone mineral density is measured according to the results of the Dual-Energy X-Ray Absorptiometry examination of the vertebral column and pelvis. Although diabetes mellitus type II (DM) is known to affect bone mineral density, at the present time this particular relationship is not clear.  Objective: The aim of current study was to evaluate the effects of type II diabetes mellitus on bone mineral density of the upper and lower limbs as well as gender differences.   Patients and Methods: This study involved 165 patients complaining of bone pain (85 males and 80 females), 85 patients of who suffered from diabetes, involving both genders. In addition, 90 apparently healthy volunteers had been studied and were considered to constitute the control group. All individuals (255) were studied regarding their bone mineral density via Dual-Energy X-Ray Absorptiometry for all parts of the body. Results: The Dual-Energy X-Ray Absorptiometry exam revealed highly statistically significant differences between the sides of the body in the same person. In addition, there were significant differences in bone mineral density between females and males, as well as between the control and patient groups with type II diabetes mellitus.  Conclusion: Our results indicated that the bone mineral density of women was less than that in men in all cases (normal, osteoporosis, and diabetes mellitus type II (DM) with osteoporosis). Other results obtained from this research revealed that diabetes mellitus type II (DM) can be considered to be one of the major causes of osteoporosis in the general populatio

Evaluation of the effect of type II diabetes mellitus on Bone Mineral Density of Upper and Lower Limbs by Dual-Energy X-Ray Absorptiometry

Background: Bone mineral density has been assessed using Dual-Energy X-Ray Absorptiometry. Bone mineral density is measured according to the results of the Dual-Energy X-Ray Absorptiometry examination of the vertebral column and pelvis. Although diabetes mellitus type II (DM) is known to affect bone mineral density, at the present time this particular relationship is not clear.  Objective: The aim of current study was to evaluate the effects of type II diabetes mellitus on bone mineral density of the upper and lower limbs as well as gender differences.   Patients and Methods: This study involved 165 patients complaining of bone pain (85 males and 80 females), 85 patients of who suffered from diabetes, involving both genders. In addition, 90 apparently healthy volunteers had been studied and were considered to constitute the control group. All individuals (255) were studied regarding their bone mineral density via Dual-Energy X-Ray Absorptiometry for all parts of the body. Results: The Dual-Energy X-Ray Absorptiometry exam revealed highly statistically significant differences between the sides of the body in the same person. In addition, there were significant differences in bone mineral density between females and males, as well as between the control and patient groups with type II diabetes mellitus.  Conclusion: Our results indicated that the bone mineral density of women was less than that in men in all cases (normal, osteoporosis, and diabetes mellitus type II (DM) with osteoporosis). Other results obtained from this research revealed that diabetes mellitus type II (DM) can be considered to be one of the major causes of osteoporosis in the general populatio

A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging

The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality-gamma ray imaging. Recently, a hybrid system-gamma plus optical imaging-has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as sentinel node detection. The hybrid camera concept can be extended to a multimodal detector design which can offer stereoscopic images, depth estimation of gamma-emitting sources, and simultaneous gamma and fluorescence imaging. Recent improvements to the hybrid camera have been used to produce dual-modality images in both laboratory simulations and in the clinic. Hybrid imaging of a patient who underwent thyroid scintigraphy is reported. In addition, we present data which shows that the hybrid camera concept can be extended to estimate the position and depth of radionuclide distribution within an object and also report the first combined gamma and Near-Infrared (NIR) fluorescence images.Peer-reviewedPublisher Versio

A Method For Source – Depth Estimation Using A Hybrid Optical / Gamma Camera

This work describes a new imaging technique to estimate the depth of radionuclide accumulations in relation to patient anatomy using a novel small field of view (SFOV) hybrid gamma camera (HGC) which combines optical and gamma imaging. The HGC offers higher spatial resolution and good sensitivity, and allows for greater flexibility for staff and patients than the conventional gamma cameras that are currently in use in nuclear medicine departments. This study aims to optimise the depth estimation technique and to assess the use of the HGC in clinical settings. Two HGCs were used to estimate the depth of radioisotope sources within a variety of phantoms and over a wide range of operating distances. Three camera arrangements (perpendicular, convergent and divergent) were investigated to select the best design for estimating the depth of the radioisotope within the phantoms; the perpendicular arrangement was found to be preferable among these arrangements. In this thesis, prototype anthropomorphic phantoms were designed and used to simulate hot spots in various regions of the human body, such as tumour localisation and sentinel lymph nodes. The HGC was used to image these phantoms with the aim of simulating a number of clinical procedures and assessing the camera performance for each. The effect of source movement on depth estimation of radiolabelled tissues was studied to simulate the effects of breathing during surgery. The HGC was used to carry out hybrid gamma-optical imaging procedures on two patients who had attended routine single photon emission computed tomography (SPECT) imaging appointments in the nuclear medicine departments at the Queen’s Medical Centre and the Nottingham City Hospital – Nottingham University Hospitals NHS Trust, Nottingham as part of clinical evaluation of the HGC. The results of the first two clinical studies of the HGC to estimate the depth of accumulated radioisotope are presented

Effect of x- ray on the treatment of breast cancer combined with amygdalin and doxorubicin separately

Background: Radiation therapy has the ability to destroy healthy cells in addition to cancer cells in the area being treated. However, when radiation combines with doxorubicin, it becomes more effective on breast cancer treatment. Objective: This study aims to clarify the effect of X-ray from LINAC combined with amygdalin and doxorubicin on breast cancer treatment, and the possibility of using amygdalin with X-ray instead of doxorubicin for the breast cancer treatment. Method: Two cell lines were used in this study, the first one was MCF-7 cell line and second one was WRL- 68 normal cell line. These cells were preserved in liquid nitrogen, prepared, developed and tested in the (place). The effect of three x-ray doses combined with amygdalin and with doxorubicin was studied on these strains. Results: Combination of radiation with amygdalin and with doxorubicin, separately, exam revealed no statistically significant difference between x-rays doses (1Gy, 3Gy and 5 Gy) combined with amygdalin and x-rays doses (1Gy, 3Gy and 5 Gy) combined with doxorubicin for MCF-7 and WRL-68.In conclusion: there is possible to be considered amygdalin as a promise breast cancer treatment instead of doxorubicin combined with x-ray

A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging

The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality-gamma ray imaging. Recently, a hybrid system-gamma plus optical imaging-has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as sentinel node detection. The hybrid camera concept can be extended to a multimodal detector design which can offer stereoscopic images, depth estimation of gamma-emitting sources, and simultaneous gamma and fluorescence imaging. Recent improvements to the hybrid camera have been used to produce dual-modality images in both laboratory simulations and in the clinic. Hybrid imaging of a patient who underwent thyroid scintigraphy is reported. In addition, we present data which shows that the hybrid camera concept can be extended to estimate the position and depth of radionuclide distribution within an object and also report the first combined gamma and Near-Infrared (NIR) fluorescence images