Seronegative spondyloarthropathies : a review : part I: classification and differential diagnosis

The seronegative spondyloarthropathies comprise a group of non-rheumatoid disorders with similar clinical, laboratory and genetic features. Recognition of new clinical features has supported the notion that they all form part of a clinical spectrum. These features and the classification of the seronegative spondyloarthropathies are discussed in the review.peer-reviewe

Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis

In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents. In this article the author describes that the HLA linked genes which is subdivided into three groups, class I, class II and class III, which are structurally and functionally distinct from each other.peer-reviewe

Scaling-up Early Learning in Ethiopia: Exploring the Potential of O-Class

SDG Target 4.2 identifies ‘pre-primary education’ as a strategy to strengthen school readiness and contribute to the quality and outcomes of education, which is supported by the powerful evidence from evaluation research. The challenge faced by many countries is to deliver the proven potential of well-planned, quality programmes to scale. This working paper summarises Ethiopia’s growing commitment to pre-primary education and reports recent Young Lives engagement with the Ministry of Education in Ethiopia and other partners to support scale-up. Ethiopia’s most recent ambitious targets for early learning have been set out in the Fifth Education Sector Development Programme (ESDP V 2015), with pre-primary classes (known as O-Class) within primary schools being seen as the most rapid route to scale-up. The paper reports on the progress and the challenges in delivering ambitious targets. We report key findings from exploratory fieldwork on two key themes, namely the response of Regional Education Bureaus in planning, financing, management and ensuring human capacity for scale-up; and the potential of Ethiopia’s Colleges of Teacher Education to supply sufficient trained teachers to work with young children, especially in the rapidly expanding O- Classes. The final section draws on parallel experiences of other countries, notably Grade R in South Africa, and reports on six key challenges for scale-up; equity; age-appropriateness; cross- sectoral coordination; capacity building; and research and evidence. Other key challenges go beyond the scope of this working paper, notably the models for governance and financing that can deliver quality early education for all. While Ethiopia’s initiative to scale-up O-Class is a welcome indicator of policy commitment to SDG Target 4.2, we conclude that there is a risk that low quality pre-primary programmes will not deliver on the potential of early childhood education and that children (especially poor children) will be the losers

Quantum state tomography of slow and stored light

Quantum information can be transferred from a beam of light to a cloud of atoms and controllably released at a later time. These quantum memory devices are fundamental to applications in quantum information science, quantum computing, and quantum communication. We propose a technique for measuring the quantum state of light that has been stored and released from a quantum memory system. This technique does not require careful mode matching can in fact be used to optimize the measured field mode without a priori knowledge of the stored light

All-Optical Switching with Transverse Optical Patterns

We demonstrate an all-optical switch that operates at ultra-low-light levels and exhibits several features necessary for use in optical switching networks. An input switching beam, wavelength $\lambda$, with an energy density of $10^{-2}$ photons per optical cross section [$\sigma=\lambda^2/(2\pi)$] changes the orientation of a two-spot pattern generated via parametric instability in warm rubidium vapor. The instability is induced with less than 1 mW of total pump power and generates several $\mu$Ws of output light. The switch is cascadable: the device output is capable of driving multiple inputs, and exhibits transistor-like signal-level restoration with both saturated and intermediate response regimes. Additionally, the system requires an input power proportional to the inverse of the response time, which suggests thermal dissipation does not necessarily limit the practicality of optical logic devices

The scope for simplified fare systems in urban bus operations

This thesis investigates the effects of introducing simplified fare systems in urban bus operations. Initially, a review of the fare systems employed by urban bus undertakings in Great Britain and Continental Western Europe is undertaken. Wide differences in policy were found to exist, with British operators tending to prefer "graduated" fares with several fare values, whilst on the European mainland simpler flat or zonal structures predominate. [Continues.