7,343 research outputs found
Kinematics of molecular gas in star-forming galaxies with large-scale ionized outflows
We investigate the kinematics of the molecular gas in a sample of seven edge-on (i > 60°) galaxies identified as hosting large-scale outflows of ionized gas, using ALMA CO(1–0) observations at ∼1 kpc resolution. We build on Hogarth et al., where we find that molecular gas is more centrally concentrated in galaxies which host winds than in control objects. We perform full three-dimensional kinematic modelling with multiple combinations of kinematic components, allowing us to infer whether these objects share any similarities in their molecular gas structure. We use modelling to pinpoint the kinematic centre of each galaxy, in order to interpret their minor- and major-axis position velocity diagrams (PVDs). From the PVDs, we find that the bulk of the molecular gas in our galaxies is dynamically cold, tracing the rotation curves predicted by our symmetric, rotation-dominated models, but with minor flux asymmetries. Most notably, we find evidence of radial gas motion in a subset of our objects, which demonstrate a characteristic ‘twisting’ in their minor-axis PVDs generally associated with gas flow along the plane of a galaxy. In our highest S/N object, we include bi-symmetric radial flow in our kinematic model, and find (via the Bayesian Information Criterion) that the presence of radial gas motion is strongly favoured. This may provide one mechanism by which molecular gas and star formation are centrally concentrated, enabling the launch of massive ionized gas winds. However, in the remainder of our sample, we do not observe evidence that gas is being driven radially, once again emphasizing the variety of physical processes that may be powering the outflows in these objects, as originally noted in H21
Pregnancy with gestational hypertension or preeclampsia: A qualitative exploration of women's experiences
© 2017 Elsevier Ltd Background Hypertension complicates 10% of pregnancies and involves specialised care of the woman and her baby, a longer stay in hospital, and an increased risk of physical and mental morbidity. There is limited research reporting the woman's perspective on her experience, how she coped with it psychologically, and whether the care she received influenced her experience. Aim To gain insight into women's experience of hypertension in pregnancy and to report on what mediating factors may help improve their experience. Methods A qualitative descriptive study was undertaken. Data were collected through a semi-structured, face to face interview at 10–12 months postpartum. In total, 20 women who had experienced hypertension in their pregnancy were interviewed. Thematic analysis was used to analyse the data. Findings Four main themes were identified. These were: Reacting to the diagnosis, Challenges of being a mother, Processing and accepting the situation, and Moving on from the experience. The mediating factors that improved the experience were Feeling safe and trusting the care providers, Having continuity of care and carer, and Valuing social support from partner, family and friends. Conclusion The diagnosis of hypertension in pregnancy has a significant impact on women. This affects their pregnancy and birth experience and their pathway to motherhood. The implications of the findings for midwifery practice include having access to multidisciplinary continuity models of care and facilitating the support for these women
Survey of abuses against injecting drug users in Indonesia
In Indonesia, an ongoing government "war on drugs" has resulted in numerous arrests and anecdotal reports of abuse in detention, but to date there has been little documentation or analysis of this issue. JANGKAR (also known in English as the Indonesian Harm Reduction Network), a nongovernmental organization (NGO) based in Jakarta, surveyed 1106 injecting drug users in 13 cities about their experiences of police abuse. Of those interviewed, 667 or 60% reported physical abuse by police. These findings indicate the importance of continuing efforts to promote police reform and harm reduction in Indonesia
Towards a Taxocomy of Brand Association Statements: The Ignorance of Measurement or a Measurement of Ignorance?
Intra-individual changes in methylome profiles: an epigenetic 'scar' of early-life adversity?
Gender Differences in Diabetes Attitudes and Adherence
This study focused on three questions: Is there a difference in men's and women's diabetes attitudes? Do health professionals give different recommendations to men and women? Is there a difference between men and women in care adherence? A total of 1201 patients with diabetes were surveyed; 65% of these patients were women. Differences in diabetes attitudes (three of seven attiticdes) were most evident between men and women with insulin-dependent diabetes mellitus (IDDM). No differences were found in the attitudes of men and women with non-insulin-dependent diabetes mellitus (NIDDM) using insulin, and only one attitude was different for patients with NIDDM not using insulin. Few differences were observed in the recommendations given by health professionals to men and women. Gender differences in adherence to the components of self-care also were minimal. These findings may indicate that there are many similarities in the reactions of men and women who have been diagnosed with diabetes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69143/2/10.1177_014572179502100605.pd
Collaboration in maternity care: A randomised controlled trial comparing community-based continuity of care with standard hospital care
Objective: To test whether a new community-based model of continuity of care provided by midwives and obstetricians improved maternal clinical outcomes, in particular a reduced caesarean section rate. Design: Randomised controlled trial. Setting: A public teaching hospital in metropolitan Sydney, Australia. Sample: 1089 women randomised to either the community-based model (n = 550) or standard hospital-based care (n = 539) prior to their first antenatal booking visit at an Australian metropolitan public hospital. Main outcome measures: Data were collected on onset and outcomes of labour, antenatal, intrapartum and postnatal complications, antenatal admissions to hospital and neonatal mortality and morbidity. Results: There was a significant difference in the caesarean section rate between the groups, 13.3% (73/550) in the community-based group and 17.8% in the control group (96/539). This difference was maintained after controlling for known contributing factors to caesarean section (OR = 0.6, 95% CI 0.4-0.9, P = 0.02). There were no other significant differences in the events during labour and birth. Eighty babies (14.5%) from the community-based group and 102 (18.9%) from the control group were admitted to the special care nursery, but this difference was not significant (OR 0.75, 95% CI 0.5-1.1, P = 0.12). Eight infants died during the perinatal period (four from each group), for an overall perinatal mortality rate of 7.3 per 1000 births. Conclusion: Community-based continuity of maternity care provided by midwives and obstetricians resulted in a significantly reduced caesarean section rate. There were no other differences in clinical outcomes
Parentage test in broad-snouted caimans (Caiman latirostris, Crocodylidae) using microsatellite DNA
In this study, microsatellite markers, developed for Alligator mississipiensis and Caiman latirostris, were used to assess parentage among individuals from the captive colony of Caiman latirostris at the University of São Paulo, in Piracicaba, São Paulo, Brazil. Many of the females in the colony were full siblings, which made maternal identification difficult due to genotypic similarity. Even so, the most likely mother could be identified unambiguously among offspring in most of the clutches studied. Two non-parental females displayed maternal behavior which would have misled managers in assigning maternity based on behavior alone. This set of variable loci demonstrates the utility of parentage testing in captive propagation programs
Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study: A nested prospective longitudinal cohort study
BACKGROUND:
Delirium is common, affecting at least 20% of older hospital inpatients. It is widely accepted that delirium is associated with dementia but the degree of causation within this relationship is unclear. Previous studies have been limited by incomplete ascertainment of baseline cognition or a lack of prospective delirium assessments. There is an urgent need for an improved understanding of the relationship between delirium and dementia given that delirium prevention may plausibly impact upon dementia prevention. A well-designed, observational study could also answer fundamental questions of major importance to patients and their families regarding outcomes after delirium.
The Delirium and Cognitive Impact in Dementia (DECIDE) study aims to explore the association between delirium and cognitive function over time in older participants. In an existing population based cohort aged 65 years and older, the effect on cognition of an episode of delirium will be measured, independent of baseline cognition and illness severity. The predictive value of clinical parameters including delirium severity, baseline cognition and delirium subtype on cognitive outcomes following an episode of delirium will also be explored.
METHODS:
Over a 12 month period, surviving participants from the Cognitive Function and Ageing Study II-Newcastle will be screened for delirium on admission to hospital. At the point of presentation, baseline characteristics along with a number of disease relevant clinical parameters will be recorded. The progression/resolution of delirium will be monitored. In those with and without delirium, cognitive decline and dementia will be assessed at one year follow-up. We will evaluate the effect of delirium on cognitive function over time along with the predictive value of clinical parameters.
DISCUSSION:
This study will be the first to prospectively elucidate the size of the effect of delirium upon cognitive decline and incident dementia. The results will be used to inform future dementia prevention trials that focus on delirium intervention
Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study
Background: Delirium is common, distressing and associated with poor outcomes. Previous studies investigating the impact
of delirium on cognitive outcomes have been limited by incomplete ascertainment of baseline cognition or lack of prospective
delirium assessments. This study quantified the association between delirium and cognitive function over time by prospectively
ascertaining delirium in a cohort aged ≥ 65 years in whom baseline cognition had previously been established.
Methods: For 12 months, we assessed participants from the Cognitive Function and Ageing Study II-Newcastle for delirium
daily during hospital admissions. At 1-year, we assessed cognitive decline and dementia in those with and without delirium.
We evaluated the effect of delirium (including its duration and number of episodes) on cognitive function over time,
independently of baseline cognition and illness severity.
Results: Eighty two of 205 participants recruited developed delirium in hospital (40%). One-year outcome data were available
for 173 participants: 18 had a new dementia diagnosis, 38 had died. Delirium was associated with cognitive decline (−1.8
Mini-Mental State Examination points [95% CI –3.5 to –0.2]) and an increased risk of new dementia diagnosis at follow
up (OR 8.8 [95% CI 1.9–41.4]). More than one episode and more days with delirium (>5 days) were associated with worse
cognitive outcomes.
Conclusions: Delirium increases risk of future cognitive decline and dementia, independent of illness severity and baseline
cognition, with more episodes associated with worse cognitive outcomes. Given that delirium has been shown to be
preventable in some cases, we propose that delirium is a potentially modifiable risk factor for dementi
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