DET MULTINATIONALE SELSKAB: EN INTERDISCIPLINÆR "GRUPPE"-SYNSVINKEL?

-

Predicting pharmacy naloxone stocking and dispensing following a statewide standing order, Indiana 2016

BACKGROUND: While naloxone, the overdose reversal medication, has been available for decades, factors associated with its availability through pharmacies remain unclear. Studies suggest that policy and pharmacist beliefs may impact availability. Indiana passed a standing order law for naloxone in 2015 to increase access to naloxone. OBJECTIVE: To identify factors associated with community pharmacy naloxone stocking and dispensing following the enactment of a statewide naloxone standing order. METHODS: A 2016 cross-sectional census of Indiana community pharmacists was conducted following a naloxone standing order. Community, pharmacy, and pharmacist characteristics, and pharmacist attitudes about naloxone dispensing, access, and perceptions of the standing order were measured. Modified Poisson and binary logistic regression models attempted to predict naloxone stocking and dispensing, respectively. RESULTS: Over half (58.1%) of pharmacies stocked naloxone, yet 23.6% of pharmacists dispensed it. Most (72.5%) pharmacists believed the standing order would increase naloxone stocking, and 66.5% believed it would increase dispensing. Chain pharmacies were 3.2 times as likely to stock naloxone. Naloxone stocking was 1.6 times as likely in pharmacies with more than one full-time pharmacist. Pharmacies where pharmacists received naloxone continuing education in the past two years were 1.3 times as likely to stock naloxone. The attempted dispensing model yielded no improvement over the constant-only model. CONCLUSIONS: Pharmacies with larger capacity took advantage of the naloxone standing order. Predictors of pharmacist naloxone dispensing should continue to be explored to maximize naloxone access

Kerr black hole quasinormal frequencies

Black-hole quasinormal modes (QNM) have been the subject of much recent attention, with the hope that these oscillation frequencies may shed some light on the elusive theory of quantum gravity. We compare numerical results for the QNM spectrum of the (rotating) Kerr black hole with an {\it exact} formula Re$\omega \to T_{BH}\ln 3+\Omega m$, which is based on Bohr's correspondence principle. We find a close agreement between the two. Possible implications of this result to the area spectrum of quantum black holes are discussed.Comment: 3 pages, 2 figure

Sensitivity analysis of sluicing-leak parameters for the 241-AX tank farm

The scope of this work was to analyze the sensitivity of contaminant fluxes from the vadose zone to the water table, to several parameters. Some of these parameters are controllable. The results were evaluated with respect to their sensitivity to the following types of parameters: hydrostratigraphy and hydraulic properties; volume, duration, and source area of leakage; simultaneous leakage from multiple tanks; pre-existing leaks; barriers to infiltration of meteoric water; and contaminant concentrations and geochemistry

Computing periodic orbits using the anti-integrable limit

Chaotic dynamics can be effectively studied by continuation from an anti-integrable limit. Using the Henon map as an example, we obtain a simple analytical bound on the domain of existence of the horseshoe that is equivalent to the well-known bound of Devaney and Nitecki. We also reformulate the popular method for finding periodic orbits introduced by Biham and Wenzel. Near an anti-integrable limit, we show that this method is guaranteed to converge. This formulation puts the choice of symbolic dynamics, required for the algorithm, on a firm foundation.Comment: 11 Pages Latex2e + 1 Figure (eps). Accepted for publication in Physics Lettes

Plot/SurfW: Plotting Utility for EDGE2D Output

This report describes a utility that was developed to display EDGE2D results. The utility is focused on results that relate to impurity density, velocity, and particle fluxes in the SOL and divertor. Due to the complicated nature of 2D impurity sources, the concentration of the thermal force near the separatrix and near the divertor entrance, the impurity flow pattern and impurity densities are not necessarily easy to visualize. Thus, we wanted a utility that allowed simple and quick visualization of the impurity behavior. In order to achieve this we overlaid the divertor hardware for plots inside the divertor and we expanded the appearance of the main chamber SOL by plotting distance along the field lines vs. SOL depth with the density (or velocity or flux or other quantity) the false colour. Also, we allowed for the plotted variable to be a function of the other EDGE2D result variables. _________________________________________________

Thermodynamics of Black Holes in Two (and Higher) Dimensions

A comprehensive treatment of black hole thermodynamics in two-dimensional dilaton gravity is presented. We derive an improved action for these theories and construct the Euclidean path integral. An essentially unique boundary counterterm renders the improved action finite on-shell, and its variational properties guarantee that the path integral has a well-defined semi-classical limit. We give a detailed discussion of the canonical ensemble described by the Euclidean partition function, and examine various issues related to stability. Numerous examples are provided, including black hole backgrounds that appear in two dimensional solutions of string theory. We show that the Exact String Black Hole is one of the rare cases that admits a consistent thermodynamics without the need for an external thermal reservoir. Our approach can also be applied to certain higher-dimensional black holes, such as Schwarzschild-AdS, Reissner-Nordstrom, and BTZ.Comment: 63 pages, 3 pdf figures, v2: added reference

Single-cell analysis of the 3D topologies of genomic loci using genome architecture mapping

Although each cell within an organism contains a nearly identical genome sequence, the three-dimensional (3D) packing of the genome varies among individual cells, influencing cell-type-specific gene expression. Genome Architecture Mapping (GAM) is the first genome-wide experimental method for capturing 3D proximities between any number of genomic loci without ligation. GAM overcomes several limitations of 3C-based methods by sequencing DNA from a large collection of thin sections sliced from individual nuclei. The GAM technique measures locus co-segregation, extracts radial positions, infers chromatin compaction, requires small numbers of cells, does not depend on ligation, and provides rich single-cell information. However, previous analyses of GAM data focused exclusively on population averages, neglecting the variation in 3D topology among individual cells. We present the first single-cell analysis of GAM data, demonstrating that the slices from individual cells reveal intercellular heterogeneity in chromosome conformation. By simultaneously clustering both slices and genomic loci, we identify topological variation among single cells, including differential compaction of cell cycle genes. We also develop a geometric model of the nucleus, allowing prediction of the 3D positions of each slice. Using GAM data from mouse embryonic stem cells, we make new discoveries about the structure of the major mammalian histone gene locus, which is incorporated into the Histone Locus Body (HLB), including structural fluctuations and putative causal molecular mechanisms. Our methods are packaged as SluiceBox, a toolkit for mining GAM data. Our approach represents a new method of investigating variation in 3D genome topology among individual cells across space and time