The Digital Millennium Copyright Act: Key Issues for Serialists

The Digital Millennium Copyright Act (DMCA) is an extremely complex piece of legislation that makes major changes to U.S. Copyright Law, specifically in the digital networked environment. Many legal and practical issues are addressed in this legislation that have an enormous impact on the library community. This session will outline the key issues for libraries and alert serialists to the issues that directly or indirectly affect their work. Whether we are concerned with access, delivery, preservation, or archiving, the DMCA affects what we do on a daily basis. In the near future, as the law is being applied and tested in court, libraries must actively identify its impact on their mission and goals, and work to assure proper protection under the law

Integrating and streamlining electronic resources workflows via Innovative’s Electronic Resource Management

This is a preprint of an article that has been accepted for publication in The Serials Librarian, v. 47, no. 4.Publisher links: http://www.taylorandfrancisgroup.com/ ; http://www.tandf.co.uk/journals/titles/0361526X.aspLibraries have been grappling with the management of the growing number of electronic resources, such as e-journals and electronic article indexes, for the last decade especially after the availability of many of these resources on the World Wide Web. The integrated library system wasn’t originally designed to accommodate many of these functions. In 2002, Innovative Interfaces, Inc. partnered with several of their customer libraries to develop a module to manage electronic resources based on the work of the Digital Library Federation’s Electronic Resources Management Initiative. The result of this partnership is a module that addresses functions such as tracking trial access, license negotiations, maintenance, troubleshooting as well as integration into the online catalog

Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B

The Dam1 complex, regulated by aurora B phosphorylation, confers a more stable microtubule association for the Ndc80 complex at kinetochores (see also related paper by Lampert et al. in this issue)

GeneMatch: A novel recruitment registry using at‐home APOE genotyping to enhance referrals to Alzheimer’s prevention studies

IntroductionRecruitment for Alzheimer’s disease (AD) prevention research studies is challenging because of lack of awareness among cognitively healthy adults coupled with the high screen fail rate due to participants not having a genetic risk factor or biomarker evidence of the disease. Participant recruitment registries offer one solution for efficiently and effectively identifying, characterizing, and connecting potential eligible volunteers to studies.MethodsIndividuals aged 55‐75 years who live in the United States and self‐report not having a diagnosis of cognitive impairment such as MCI or dementia are eligible to join GeneMatch. Participants enroll online and are provided a cheek swab kit for DNA extraction and apolipoprotein E (APOE) genotyping. Participants are not told their APOE results, although the results may be used in part to help match participants to AD prevention studies.ResultsAs of August 2018, 75,351 participants had joined GeneMatch. Nearly 30% of participants have one APOE4 allele, and approximately 3% have two APOE4 alleles. The percentages of APOE4 heterozygotes and homozygotes are inversely associated with age (P < .001).DiscussionGeneMatch, the first trial‐independent research enrollment program designed to recruit and refer cognitively healthy adults to AD prevention studies based in part on APOE test results, provides a novel mechanism to accelerate prescreening and enrollment for AD prevention trials.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152681/1/alzjjalz201812007.pd