23 research outputs found
Protocol of a Randomized Controlled Trial of Culturally Sensitive Interventions to Improve African Americans' and Non-African Americans' Early, Shared, and Informed Consideration of Live Kidney Transplantation: The talking about Live Kidney Donation (TALK) study
<p>Abstract</p> <p>Background</p> <p>Live kidney transplantation (LKT) is underutilized, particularly among ethnic/racial minorities. The effectiveness of culturally sensitive educational and behavioral interventions to encourage patients' early, shared (with family and health care providers) and informed consideration of LKT and ameliorate disparities in consideration of LKT is unknown.</p> <p>Methods/Design</p> <p>We report the protocol of the Talking About Live Kidney Donation (TALK) Study, a two-phase study utilizing qualitative and quantitative research methods to design and test culturally sensitive interventions to improve patients' shared and informed consideration of LKT. Study Phase 1 involved the evidence-based development of culturally sensitive written and audiovisual educational materials as well as a social worker intervention to encourage patients' engagement in shared and informed consideration of LKT. In Study Phase 2, we are currently conducting a randomized controlled trial in which participants with progressing chronic kidney disease receive: 1) usual care by their nephrologists, 2) usual care plus the educational materials, or 3) usual care plus the educational materials and the social worker intervention. The primary outcome of the randomized controlled trial will include patients' self-reported rates of consideration of LKT (including family discussions of LKT, patient-physician discussions of LKT, and identification of an LKT donor). We will also assess differences in rates of consideration of LKT among African Americans and non-African Americans.</p> <p>Discussion</p> <p>The TALK Study rigorously developed and is currently testing the effectiveness of culturally sensitive interventions to improve patients' and families' consideration of LKT. Results from TALK will provide needed evidence on ways to enhance consideration of this optimal treatment for patients with end stage renal disease.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov number, <a href="http://www.clinicaltrials.gov/ct2/show/NCT00932334">NCT00932334</a></p
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
The Science Performance of JWST as Characterized in Commissioning
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines
Cajal bodies (CBs) are nuclear structures that are thought to have diverse
functions, including small nuclear ribonucleoprotein (snRNP) biogenesis. The
phosphorylation status of coilin, the CB marker protein, might impact CB
formation. We hypothesize that primary cells, which lack CBs, contain
different phosphoisoforms of coilin compared with that found in transformed
cells, which have CBs. Localization, self-association and fluorescence
recovery after photobleaching (FRAP) studies on coilin phosphomutants all
suggest this modification impacts the function of coilin and may thus
contribute towards CB formation. Two-dimensional gel electrophoresis
demonstrates that coilin is hyperphosphorylated in primary cells compared with
transformed cells. mRNA levels of the nuclear phosphatase PPM1G are
significantly reduced in primary cells and expression of PPM1G in primary
cells induces CBs. Additionally, PPM1G can dephosphorylate coilin in vitro.
Surprisingly, however, expression of green fluorescent protein alone is
sufficient to form CBs in primary cells. Taken together, our data support a
model whereby coilin is the target of an uncharacterized signal transduction
cascade that responds to the increased transcription and snRNP demands found
in transformed cells
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What Can Professional Scientific Societies Do to Improve Diversity, Equity, and Inclusion: A Case Study of the American Elasmobranch Society
Scientific professional societies are reviewing diversity, equity, and inclusion (DEI) practices and policies in response to recent calls for much-needed change. Organizations like scientific professional societies contribute to establishing disciplinary norms, and can influence the diversity of disciplinary workforces in multiple ways through both action and inaction. This paper examines these issues using the American Elasmobranch Society (AES), a medium-sized professional scientific society, as a case study. It consists of three parts: (1) an analysis of the demographics of AES members, leaders, and award winners; (2) an evaluation of a diversity initiative created by the society which includes a survey of program alumni focusing on potential improvements to the program; and (3) a synthesis of recommendations of steps that AES and similarly sized societies can take to better support DEI goals. AES’s membership in recent years is more than half women, but 71.5% of all leadership positions in the Society’s history (including all but two Presidents) have been held by men since the society was founded in 1983. AES’s membership has significantly fewer Black/African-American members than the United States scientific workforce overall, with just 1 member out of over 400 identifying as Black in 2019, and 86.6% of Society leadership positions have been held by white-presenting members. The Society’s diversity initiative has led to some limited professional benefits for awardees, but could benefit from additional resources and support to enact suggested expansions and improvements. We provide a series of actionable recommendations that will make the annual meetings of societies like AES, and the field of chondrichthyan science, safer and more inclusive