Teaching Social Skills to Individuals with Comorbid Down Syndrome and Autism Spectrum Disorder: A Single-Subject Design Study

Social skills are important for building and maintaining relationships, effective communication, and providing appropriate responses within social contexts. Deficits in social skills are often exhibited in individuals with comorbid Down syndrome (DS) and autism spectrum disorder (ASD). Peer-delivered interventions and other behavioral techniques for teaching specific social skills show effectiveness; however, the paucity of intervention research including individuals with DS-ASD has resulted in little guidance for how best to teach social skills and ensure generalization and maintenance. In the present study, a multiple probe study across behaviors, replicated across participants, assessed the effectiveness of peer-delivered simultaneous prompting in teaching socials skills to four adults with DS-ASD. The overarching purposes of this project were (a) to explore whether peer-mediators with DS-only can use simultaneous prompting reliably for teaching social skills, and (b) to examine the influence of simultaneous prompting to teach social skills to adults with dual-diagnoses of DS and ASD. Study findings add to the DS-ASD literature base on intervention design and implementation as well as the literature base for intervention delivery by peers with identified developmental and intellectual disabilities

The United States Chiropractic Workforce: An alternative or complement to primary care?

UnlabelledBackgroundIn the United States (US) a shortage of primary care physicians has become evident. Other health care providers such as chiropractors might help address some of the nation's primary care needs simply by being located in areas of lesser primary care resources. Therefore, the purpose of this study was to examine the distribution of the chiropractic workforce across the country and compare it to that of primary care physicians.MethodsWe used nationally representative data to estimate the per 100,000 capita supply of chiropractors and primary care physicians according to the 306 predefined Hospital Referral Regions. Multiple variable Poisson regression was used to examine the influence of population characteristics on the supply of both practitioner-types.ResultsAccording to these data, there are 74,623 US chiropractors and the per capita supply of chiropractors varies more than 10-fold across the nation. Chiropractors practice in areas with greater supply of primary care physicians (Pearson's correlation 0.17, p-value < 0.001) and appear to be more responsive to market conditions (i.e. more heavily influenced by population characteristics) in regards to practice location than primary care physicians.ConclusionThese findings suggest that chiropractors practice in areas of greater primary care physician supply. Therefore chiropractors may be functioning in more complementary roles to primary care as opposed to an alternative point of access

Cation–π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation

Cation–π interactions are common in biological systems, and many structural studies have revealed the aromatic box as a common motif. With the aim of understanding the nature of the aromatic box, several computational methods were evaluated for their ability to reproduce experimental cation–π binding energies. We find the DFT method M06 with the 6-31G(d,p) basis set performs best of several methods tested. The binding of benzene to a number of different cations (sodium, potassium, ammonium, tetramethylammonium, and guanidinium) was studied. In addition, the binding of the organic cations NH_4+ and NMe_4+ to ab initio generated aromatic boxes as well as examples of aromatic boxes from protein crystal structures were investigated. These data, along with a study of the distance dependence of the cation–π interaction, indicate that multiple aromatic residues can meaningfully contribute to cation binding, even with displacements of more than an angstrom from the optimal cation–π interaction. Progressive fluorination of benzene and indole was studied as well, and binding energies obtained were used to reaffirm the validity of the “fluorination strategy” to study cation–π interactions in vivo

Population and Phase Coherence during the Growth of an Elongated Bose-Einstein Condensate

We study the growth of an elongated phase-fluctuating condensate from a non-equilibrium thermal cloud obtained by shock-cooling. We compare the growth of the condensate with numerical simulations, revealing a time delay and a reduction in the growth rate which we attribute to phase fluctuations. We measure the phase coherence using momentum Bragg spectroscopy, and thereby observe the evolution of the phase coherence as a function of time. Combining the phase coherence results with the numerical simulations, we suggest a simple model for the reduction of the growth rate based on the reduction of bosonic stimulation due to phase fluctuations and obtain improved agreement between theory and experiment

Phase and micromotion of Bose-Einstein condensates in a time-averaged ring trap

Rapidly scanning magnetic and optical dipole traps have been widely utilised to form time-averaged potentials for ultracold quantum gas experiments. Here we theoretically and experimentally characterise the dynamic properties of Bose-Einstein condensates in ring-shaped potentials that are formed by scanning an optical dipole beam in a circular trajectory. We find that unidirectional scanning leads to a non-trivial phase profile of the condensate that can be approximated analytically using the concept of phase imprinting. While the phase profile is not accessible through in-trap imaging, time-of-flight expansion manifests clear density signatures of an in-trap phase step in the condensate, coincident with the instantaneous position of the scanning beam. The phase step remains significant even when scanning the beam at frequencies two orders of magnitude larger than the characteristic frequency of the trap. We map out the phase and density properties of the condensate in the scanning trap, both experimentally and using numerical simulations, and find excellent agreement. Furthermore, we demonstrate that bidirectional scanning eliminated the phase gradient, rendering the system more suitable for coherent matter wave interferometry.Comment: 10 pages, 7 figure

Quantitative acoustic models for superfluid circuits

We experimentally realize a highly tunable superfluid oscillator circuit in a quantum gas of ultracold atoms and develop and verify a simple lumped-element description of this circuit. At low oscillator currents, we demonstrate that the circuit is accurately described as a Helmholtz resonator, a fundamental element of acoustic circuits. At larger currents, the breakdown of the Helmholtz regime is heralded by a turbulent shedding of vortices and density waves. Although a simple phase-slip model offers qualitative insights into the circuit's resistive behavior, our results indicate deviations from the phase-slip model. A full understanding of the dissipation in superfluid circuits will thus require the development of empirical models of the turbulent dynamics in this system, as have been developed for classical acoustic systems.Comment: 12 pages, 9 figure

Classical Region of a Trapped Bose Gas

The classical region of a Bose gas consists of all single-particle modes that have a high average occupation and are well-described by a classical field. Highly-occupied modes only occur in massive Bose gases at ultra-cold temperatures, in contrast to the photon case where there are highly-occupied modes at all temperatures. For the Bose gas the number of these modes is dependent on the temperature, the total number of particles and their interaction strength. In this paper we characterize the classical region of a harmonically trapped Bose gas over a wide parameter regime. We use a Hartree-Fock approach to account for the effects of interactions, which we observe to significantly change the classical region as compared to the idealized case. We compare our results to full classical field calculations and show that the Hartree-Fock approach provides a qualitatively accurate description of classical region for the interacting gas.Comment: 6 pages, 5 figures; updated to include new results with interaction

Maximum likelihood estimation for α\alpha-stable autoregressive processes

We consider maximum likelihood estimation for both causal and noncausal autoregressive time series processes with non-Gaussian $\alpha$-stable noise. A nondegenerate limiting distribution is given for maximum likelihood estimators of the parameters of the autoregressive model equation and the parameters of the stable noise distribution. The estimators for the autoregressive parameters are $n^{1/\alpha}$-consistent and converge in distribution to the maximizer of a random function. The form of this limiting distribution is intractable, but the shape of the distribution for these estimators can be examined using the bootstrap procedure. The bootstrap is asymptotically valid under general conditions. The estimators for the parameters of the stable noise distribution have the traditional $n^{1/2}$ rate of convergence and are asymptotically normal. The behavior of the estimators for finite samples is studied via simulation, and we use maximum likelihood estimation to fit a noncausal autoregressive model to the natural logarithms of volumes of Wal-Mart stock traded daily on the New York Stock Exchange.Comment: Published in at http://dx.doi.org/10.1214/08-AOS632 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org