1,172 research outputs found
Inaugural Artificial Intelligence for Public Health Practice (AI4PHP) Retreat: Ontario, Canada
The Artificial Intelligence (AI) for Public Health Practice Retreat was a hybrid event held in October 2022 in London, Ontario to achieve three main goals: 1) Identify both the goals of public health practitioners and the tasks that they undertake as part of their practice to achieve those goals that could be supported by AI, 2) Learn from existing examples and the experience of others about facilitators and barriers to AI for public health, and 3) Support new and strengthen existing connections between public health practitioners and AI researchers. The retreat included a keynote presentation, group brainstorming exercises, breakout group activities, case studies, and interspersed breaks for networking and reflection. There were 38 attendees from across Ontario, and a guest speaker from New York. Major themes that emerged from discussions included the need for greater attention to AI applications in public health given the potential benefits and enthusiasm; rigorous data collection, data quality, and data accessibility as a foundational factor that needs urgent attention; and the need for an equitable systems-thinking approach to AI amidst the breadth of public health functions, interventions, and population-based applications. Attendees expressed a desire for continued engagement and collaboration between public health practice and AI researchers
Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding
Background: We sought to determine if ripple oscillations (80-120Hz),
detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate
with an enhancement or disruption of verbal episodic memory encoding. Methods:
We defined ripple and spike events in depth iEEG recordings during list
learning in 107 patients with focal epilepsy. We used logistic regression
models (LRMs) to investigate the relationship between the occurrence of ripple
and spike events during word presentation and the odds of successful word
recall following a distractor epoch, and included the seizure onset zone (SOZ)
as a covariate in the LRMs. Results: We detected events during 58,312 word
presentation trials from 7,630 unique electrode sites. The probability of
ripple on spike (RonS) events was increased in the seizure onset zone (SOZ,
p<0.04). In the left temporal neocortex RonS events during word presentation
corresponded with a decrease in the odds ratio (OR) of successful recall,
however this effect only met significance in the SOZ (OR of word recall 0.71,
95% CI: 0.59-0.85, n=158 events, adaptive Hochberg p<0.01). Ripple on
oscillation events (RonO) that occurred in the left temporal neocortex non-SOZ
also correlated with decreased odds of successful recall (OR 0.52, 95% CI:
0.34-0.80, n=140, adaptive Hochberg , p<0.01). Spikes and RonS that occurred
during word presentation in the left middle temporal gyrus during word
presentation correlated with the most significant decrease in the odds of
successful recall, irrespective of the location of the SOZ (adaptive Hochberg,
p<0.01). Conclusion: Ripples and spikes generated in left temporal neocortex
are associated with impaired verbal episodic memory encoding
The Hubble constant and dark energy from cosmological distance measures
We study how the determination of the Hubble constant from cosmological
distance measures is affected by models of dark energy and vice versa. For this
purpose, constraints on the Hubble constant and dark energy are investigated
using the cosmological observations of cosmic microwave background, baryon
acoustic oscillations and type Ia suprenovae. When one investigates dark
energy, the Hubble constant is often a nuisance parameter, thus it is usually
marginalized over. On the other hand, when one focuses on the Hubble constant,
simple dark energy models such as a cosmological constant and a constant
equation of state are usually assumed. Since we do not know the nature of dark
energy yet, it is interesting to investigate the Hubble constant assuming some
types of dark energy and see to what extent the constraint on the Hubble
constant is affected by the assumption concerning dark energy. We show that the
constraint on the Hubble constant is not affected much by the assumption for
dark energy. We furthermore show that this holds true even if we remove the
assumption that the universe is flat. We also discuss how the prior on the
Hubble constant affects the constraints on dark energy and/or the curvature of
the universe.Comment: 45 pages, 15 figure
Conditioning Intensity, Pre-Transplant Flow Cytometric Measurable Residual Disease, and Outcome in Adults with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation
How conditioning intensity is related to outcomes of AML patients undergoing allografting in morphologic remission is an area of great ongoing interest. We studied 743 patients in morphologic remission and known pre-transplant measurable residual disease (MRD) status determined by multiparameter flow cytometry (MFC) who received a first allograft after myeloablative, reduced intensity, or nonmyeloablative conditioning (MAC, RIC, and NMA). Overall, relapse-free survival (RFS) and overall survival (OS) were longer after MAC than RIC or NMA conditioning, whereas relapse risks were not different. Among MRD(pos)patients, 3-year estimates of relapse risks and survival were similar across conditioning intensities. In contrast, among MRD(neg)patients, 3-year RFS and OS were longer for MAC (69% and 71%) than RIC (47% and 55%) and NMA conditioning (47% and 52%). Three-year relapse risks were lowest after MAC (18%) and highest after NMA conditioning (30%). Our data indicate an interaction between conditioning intensity, MFC-based pre-transplant MRD status, and outcome, with benefit of intensive conditioning primarily for patients transplanted in MRD(neg)remission. Differing from recent findings from other studies that indicated MAC is primarily beneficial for some or all patients with MRD(pos)pre-HCT status, our data suggest MAC should still be considered for MRD(neg)AML patients if tolerated
Space Shuttle Orbiter Structures and Mechanisms
The Space Shuttle Orbiter has performed exceptionally well over its 30 years of flight experience. Among the many factors behind this success were robust, yet carefully monitored, structural and mechanical systems. From highlighting key aspects of the design to illustrating lessons learned from the operation of this complex system, this paper will attempt to educate the reader on why some subsystems operated flawlessly and why specific vulnerabilities were exposed in others. Specific areas to be covered will be the following: high level configuration overview, primary and secondary structure, mechanical systems ranging from landing gear to the docking system, and windows
Constraints on the Timing and Extent of Deglacial Grounding Line Retreat in West Antarctica
Projections of Antarctica\u27s contribution to future sea level rise are associated with significant uncertainty, in part because the observational record is too short to capture long-term processes necessary to estimate ice mass changes over societally relevant timescales. Records of grounding line retreat from the geologic past offer an opportunity to extend our observations of these processes beyond the modern record and to gain a more comprehensive understanding of ice-sheet change. Here, we present constraints on the timing and inland extent of deglacial grounding line retreat in the southern Ross Sea, Antarctica, obtained via direct sampling of a subglacial lake located 150 km inland from the modern grounding line and beneath \u3e1 km of ice. Isotopic measurements of water and sediment from the lake enabled us to evaluate how the subglacial microbial community accessed radiocarbon-bearing organic carbon for energy, as well as where it transferred carbon metabolically. Using radiocarbon as a natural tracer, we found that sedimentary organic carbon was microbially translocated to dissolved carbon pools in the subglacial hydrologic system during the 4.5-year period of water accumulation prior to our sampling. This finding indicates that the grounding line along the Siple Coast of West Antarctica retreated more than 250 km inland during the mid-Holocene (6.3 ± 1.0 ka), prior to re-advancing to its modern position
Large scale dynamics in turbulent Rayleigh-Benard convection
The progress in our understanding of several aspects of turbulent
Rayleigh-Benard convection is reviewed. The focus is on the question of how the
Nusselt number and the Reynolds number depend on the Rayleigh number Ra and the
Prandtl number Pr, and on how the thicknesses of the thermal and the kinetic
boundary layers scale with Ra and Pr. Non-Oberbeck-Boussinesq effects and the
dynamics of the large-scale convection-roll are addressed as well. The review
ends with a list of challenges for future research on the turbulent
Rayleigh-Benard system.Comment: Review article, 34 pages, 13 figures, Rev. Mod. Phys. 81, in press
(2009
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
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