Clinical management of six cases of low-risk primary tonsillar non-Hodgkin´s lymphoma

CONTEXT: There have been many reports that favor aggressive systemic treatment with chemotherapy and radiotherapy, even for well-localized lymphomas, avoiding the need for tonsillectomy of the normal tonsil. CASE REPORT: We report six cases of primary tonsillar lymphoma with a median patient age of 42 years. There were two lymphoma cases with diffuse large cells, two cases with mixed small and large cells, one with small cells and one indeterminate. They were treated with six cycles of chemotherapy and cervical radiotherapy. All patients achieved durable complete remission. Our data agree with previous reports that suggested that primary tonsillar high-grade B-cell NHL has a good prognosis if aggressively treated.CONTEXTO: Muitos trabalhos têm proposto tratamento sistêmico agressivo com quimioterapia e radioterapia para os linfomas de tonsila palatina, mesmo tratando-se de tumores bem localizados, sem a necessidade de amidalectomia contralateral. RELATO DE CASO: Nós relatamos seis casos de linfoma primário de tonsila palatina, com idade mediana de 42 anos. Havia dois casos de linfoma difuso de grandes células, dois casos de linfoma de pequenas e grandes células, um caso de linfoma linfocítico de pequenas células e um caso indeterminado. Foram tratados com seis ciclos de quimioterapia e radioterapia cervical. Todos os pacientes atingiram remisão completa mantida. Nossos dados estão de acordo com relatos prévios que sugerem que os linfomas de células B têm bom prognóstico se agressivamente tratados.Universidade Federal de São Paulo (UNIFESP)Escola Paulista de MedicinaUNIFESP, EPMSciEL

Características clínicas, laboratoriais e epidemiológicas do linfoma/leucemia de células T do adulto

BV UNIFESP: Teses e dissertaçõe

Does COVID‐19 really impact on the oxy‐hemoglobin dissociation curve?

Abstract The COVID‐19 pandemic has had a crucial impact on lifestyle worldwide. In this way, many studies have been presented, leading to continuous revaluation and questioning of conducts and concepts. Such is the case of the Chinese study suggesting that the new coronavirus has the potential to code anomalous nonstructural proteins capable of dissociating the iron atom from the porphyrin structure, contributing significantly to the characteristic hypoxemia conditions of the disease. Considering the potential impacts of those findings, the current study aims to evaluate and measure the dissociation curve of oxy‐hemoglobin in COVID‐19 patients. The project consists of a retrospective cohort study with data regarding oximetry and hemoglobin levels collected from digital patients records. The correlation between the measures and estimated values by Spearmen test was 0.843 (P < .001). A multiple linear regression model was applied using measured SO2 as a predicted variable and hemoglobin, PO2, and pH levels as predictors. The coefficients were pH 0.16‐0.31 (P < .001); PO2 0.52‐0.66 (P < .001) and Hb 0.088‐0.059 (P = .706). Despite its limitations, the present study suggests that, at least in situations of clinical severity, the proposed mechanism does not appear to be universal or to have a significant clinical impact

HTLV-I infection among relatives of patients with adult T-cell Leukemia/Lymphoma in Brazil: Analysis of infection transmission

We examined the presence of HTLV-I infection among 66 family members of 13 patients with well documented ATL to investigate the routes of HLTV-I transmission in a Southeast region of Brazil. HTLV-I infection was screened by an enzyme immunossay (ELISA) test and an repeatedly positive or indeterminate ELISA samples were further tested by a Western-Blot (WB) technique. Indeterminate and inconclusive WE samples were confirmed by a polymerase chain reaction (PCR). ELISA results showed that 40 (60.6%) individuals were not infected; 16 (24.2%) were positive; and 10 (15.2%) were undetermined. Among 16 ELISA positive subjects, 14 (87.5%) were confirmed to be positive by WE while 2 (12.5%) showed inconclusive results. Based on the laboratory data, questionnaire analysis, and family/epidemiological studies, we concluded that HTLV-I vertical transmission occurred in 6 of the 13 families. In 3 of these 6 families, the horizontal transmission also could be demonstrated. An isolated horizontal transmission was detected in one family, and in 6 families we did not find any infected family member. All HTLV-I-infected persons were clinically asymptomatic. The occurrence of an effective HTLV-I vertical transmission detected by the present study suggest that HTLV-I infection is endemic in the Southeast region of Brazil. Consistent with the modes of transmission, the HTLV-I antibody seroprevalence was greater in relatives of ATL patients than in the general blood donor Brazilian population (0.4%). In addition, the present data suggest that HTLV-I carries a high infectivity rate but a low virulence.Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Hematol & Hemoterapia, Hematol & Transfus Med Serv, BR-04023900 Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Hematol & Hemoterapia, Hematol & Transfus Med Serv, BR-04023900 Sao Paulo, BrazilWeb of Scienc