Multilayer Extraction of Complex Refractive Index in Broadband Transmission Terahertz Time-Domain Spectroscopy

In terahertz spectroscopy, multi-layered samples often need to be measured, for instance in a liquid flow cell, and this complicates the extraction of material parameters. We present a spectroscopic parameter extraction algorithm for multilayer samples that can also be used to extract the thickness of an unknown sample laye

Estimation of Spectroscopic Uncertainty and Correlation in Terahertz Time Domain Spectroscopy

We present a method of calculating the measurement variance-covariance matrix of a spectroscopic sample’s complex refractive index from time-domain statistics in order to estimate uncertainty of a measurement. We compare this method to a numerical analysis and previously derived methodology, and show that our time-based estimate is both accurate and adaptable to complex extraction models

The role of industry studies and public policies in production and operations management

The research domain Industry Studies and Public Policy (IS&PP) seeks to further our understanding of industrial practices and managerial challenges by explicitly considering contextual details in the design and interpretation of research studies. These details can be vital considerations when shaping public policies. This article reviews a sample of IS&PP publications and analyzes the content of 180 selected papers — 85 papers published in the $\textit{Production and Operations Management}$ (POM) journal and 95 papers published in related journals between 1992 and 2014. Our analysis of the sample dataset and examination of exemplar papers provide four findings. First, studies in different industries emphasize different themes of operational decisions. This difference in emphasis reveals potential research opportunities, especially for conducting inter-industry studies. Second, our analysis reveals a shift in focus over time. Earlier studies contain a mix of benchmarks and inter-industry comparisons, while later studies tend to be context-specific, intra-industry studies. Third, we report on empirics→ analytics→ empirics cycles that reveal gaps for building novel theories. Finally, we observe that the relationship between POM decisions and public policy is bi-directional. This highlights the need to jointly examine operational decisions with policy considerations, especially in information goods, healthcare, sustainable operations and high-tech manufacturing industries

The role of industry studies and public policies in production and operations management

The research domain Industry Studies and Public Policy (IS&PP) seeks to further our understanding of industrial practices and managerial challenges by explicitly considering contextual details in the design and interpretation of research studies. These details can be vital considerations when shaping public policies. This article reviews a sample of IS&PP publications and analyzes the content of 180 selected papers — 85 papers published in the $\textit{Production and Operations Management}$ (POM) journal and 95 papers published in related journals between 1992 and 2014. Our analysis of the sample dataset and examination of exemplar papers provide four findings. First, studies in different industries emphasize different themes of operational decisions. This difference in emphasis reveals potential research opportunities, especially for conducting inter-industry studies. Second, our analysis reveals a shift in focus over time. Earlier studies contain a mix of benchmarks and inter-industry comparisons, while later studies tend to be context-specific, intra-industry studies. Third, we report on empirics→ analytics→ empirics cycles that reveal gaps for building novel theories. Finally, we observe that the relationship between POM decisions and public policy is bi-directional. This highlights the need to jointly examine operational decisions with policy considerations, especially in information goods, healthcare, sustainable operations and high-tech manufacturing industries

THz-TDS of liquids in a temperature-controlled transmission flowcell

Precise temperature-control is necessary for many spectroscopic measurements. We present the temperature-dependent complex THz refractive index of liquid samples measured in a flowcell, analysed by a numerical method that allows simultaneous extraction of the sample's thickness to verify the temperature-stability of the cell

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

Linear ubiquitin chains are important regulators of cellular signaling pathways that control innate immunity and inflammation through NF-κB activation and protection against TNFα-induced apoptosis(1-5). They are synthesized by HOIP, which belongs to the RBR (RING-between-RING) family of E3 ligases and is the catalytic component of LUBAC (linear ubiquitin chain assembly complex), a multi-subunit E3 ligase(6). RBR family members act as RING/HECT hybrids, employing RING1 to recognize ubiquitin-loaded E2 while a conserved cysteine in RING2 subsequently forms a thioester intermediate with the transferred or “donor” ubiquitin(7). Here we report the crystal structure of the catalytic core of HOIP in its apo form and in complex with ubiquitin. The C-terminal portion of HOIP adopts a novel fold that, together with a zinc finger, forms an ubiquitin-binding platform which orients the acceptor ubiquitin and positions its α-amino group for nucleophilic attack on the E3~ubiquitin thioester. The carboxy-terminal tail of a second ubiquitin molecule is located in close proximity to the catalytic cysteine providing a unique snapshot of the ubiquitin transfer complex containing both donor and acceptor ubiquitin. These interactions are required for activation of the NF-kB pathway in vivo and explain the determinants of linear ubiquitin chain specificity by LUBAC