Barriers to Adoption of Advanced E-business in Welsh Small and Medium Sized Enterprises

The eCommerce Innovation Centre (eCIC) at Cardiff University has a central role in Opportunity Wales, a programme providing e-business support to over 9000 Small and Medium sized Enterprises (SMEs) during the last five years. Uptake of advanced e-business adoption has been low during the programme as well as throughout Wales in general. This paper reports on the findings of a pilot study that was undertaken in the fifth year (2006) of the programme. The approach taken to identify the key barriers to adoption was through interviews with a cross section of expert delivery partners and a sample of SMEs that advanced e-business was relevant to. The key objectives were to understand the barriers to adoption in respect of the current programme as well to help planning for future support initiatives. In addition, the research would help identify and overcome certain barriers in relation to the objectives of the Lisbon Strategy. The paper concludes that varying definitions of e-business inhibit our understanding of uptake when comparing to other studies or initiatives. Also, the strategic planning of ebusiness, where relevant, will reduce barriers to advanced ebusiness adoption, as will the lessons learned from SMEs who have successfully made the transition

The World Distribution of Household Wealth

There has been much recent research on the world distribution of income, but also growing recognition of the importance of other contributions to well-being, including those of household wealth. Wealth is important in providing security and opportunity, particularly in poorer countries that lack full social safety nets and adequate facilities for borrowing and lending. We find, however, that it is precisely in the latter countries where household wealth is the lowest, both in absolute and relative terms. Globally, wealth is more concentrated than income both on an individual and national basis. Roughly 30 per cent of world wealth is found in each of North America, Europe, and the rich Asian-Pacific countries. These areas account for virtually all of the world?s top 1 per cent of wealth holders. On an official exchange rate basis India accounts for about a quarter of the adults in the bottom three global wealth deciles while China provides about a third of those in the fourth to eighth deciles. If current growth trends continue, India, China and the transition countries will move up in the global distribution, and the lower deciles will be increasingly dominated by countries in Africa, Latin American and poor parts of the Asian-Pacific region. Thus wealth may continue to be lowest in areas where it is needed the most.wealth, net worth, personal assets, wealth inequality, households, balance sheets, portfolios

Estimating the level and distribution of global wealth, 2000-14

Davies et al. (2008, 2011) provided the first estimates of the global distribution of wealth, using 2000 as the benchmark year. These estimates have been revised and updated since 2010, and the purpose of this paper is to explain the ways in which the estimation methodology has evolved and improved in recent years. Further, the paper summarizes lessons learned about trends in the level and distribution of global wealth for the period 2000-14. Finally, the paper discusses the results in the context of the discourse provoked by Piketty (2014)

Estimating the level and distribution of global household wealth

We provide the first estimate of the level and distribution of global household wealth. Mean assets and debts within countries are measured, partly or wholly, for 38 countries using household balance sheet and survey data centred on the year 2000. Determinants of mean financial assets, non-financial assets, and liabilities are studied empirically, and the results are used to impute values to countries lacking wealth data. Household wealth per adult is US$43,494 in PPP terms, and ranges regionally from US$11,655 in Africa to US$193,147 in North America. Data on the shape of the household distribution of wealth for 20 countries, accounting for 59 per cent of the world’s population and, we estimate, 84 per cent of its wealth are used to establish patterns of wealth inequality within countries. Imputations are again performed for countries lacking wealth data, on the basis of the observed relation between wealth and income distribution for the 20 countries with data. The Gini coefficient for the global distribution of wealth is 0.804, and the share of the top 10 per cent is 71 per cent. Wealth of US$8,325 is needed to be in the top half of the distribution, and US$517,601 is needed to be in the top one per cent. Between-country differences in wealth are two-thirds of global inequality according to the Gini coefficient, indicating a larger role for within-country inequality than in the case of income according to recent estimates. – wealth ; net worth ; personal assets ; inequality ; households ; balance sheets ; portfolio

The Level and Distribution of Global Household Wealth

We estimate the level and distribution of global household wealth. The levels of assets and debts for 39 countries are measured using household balance sheet and survey data centred on the year 2000. The determinants of mean financial assets, non-financial assets, and liabilities are studied empirically, and the results used to estimate average wealth holdings for countries lacking direct evidence. Data on the pattern of household distribution of wealth are assembled for 20 countries, which together account for 59 per cent of the global population and 75 per cent of global wealth. The observed relation between wealth and income distribution in these 20 countries allows estimates of wealth inequality to be produced for many other nations. Combining the figures for individual countries reveals that net worth averaged US$44,024 per adult in PPP terms across the globe. Wealth of US$8,635 was needed to be in the top half of the global distribution, and US$518,364 to be in the top one per cent. The top 10 per cent owned 71 per cent of world wealth, and the Gini coefficient for the global distribution of wealth is estimated to be 0.802, indicating greater inequality than that observed in the global distribution of consumption or income.

The World Distribution of Household Wealth

We thank participants at the May 2006 WIDER project meeting on Personal Assets from a Global Perspective for their valuable comments and suggestions. Special thanks are due to Tony Atkinson and Markus Jäntti. Responsibility for all errors or omissions is our own. 1

Oncolytic adenovirus: strategies and insights for vector design and immuno-oncolytic applications

Adenoviruses (Ad) are commonly used both experimentally and clinically, including oncolytic virotherapy applications. In the clinical area, efficacy is frequently hampered by the high rates of neutralizing immunity, estimated as high as 90% in some populations that promote vector clearance and limit bioavailability for tumor targeting following systemic delivery. Active tumor targeting is also hampered by the ubiquitous nature of the Ad5 receptor, hCAR, as well as the lack of highly tumor-selective targeting ligands and suitable targeting strategies. Furthermore, significant off-target interactions between the viral vector and cellular and proteinaceous components of the bloodstream have been documented that promote uptake into non-target cells and determine dose-limiting toxicities. Novel strategies are therefore needed to overcome the obstacles that prevent efficacious Ad deployment for wider clinical applications. The use of less seroprevalent Ad serotypes, non-human serotypes, capsid pseudotyping, chemical shielding and genetic masking by heterologous peptide incorporation are all potential strategies to achieve efficient vector escape from humoral immune recognition. Conversely, selective vector arming with immunostimulatory agents can be utilized to enhance their oncolytic potential by activation of cancer-specific immune responses against the malignant tissues. This review presents recent advantages and pitfalls occurring in the field of adenoviral oncolytic therapies

A new parafocusing paradigm for X-ray diffraction

A new approach to parafocusing X-ray diffraction implemented with an annular incident beam is demonstrated for the first time. The method exploits an elliptical specimen path on a flat sample to produce relatively high intensity maxima that can be measured with a point detector. It is shown that the flat-specimen approximation tolerated by conventional Bragg–Brentano geometries is not required. A theoretical framework, simulations and experimental results for both angular- and energy-dispersive measurement modes are presented and the scattering signatures compared with data obtained with a conventional pencil-beam arrangement