Weak lensing by voids in weak lensing maps

Cosmic voids are an important probe of large-scale structure that can constrain cosmological parameters and test cosmological models. We present a new paradigm for void studies: void detection in weak lensing convergence maps. This approach identifies objects that relate directly to our theoretical understanding of voids as underdensities in the total matter field and presents several advantages compared to the customary method of finding voids in the galaxy distribution. We exemplify this approach by identifying voids using the weak lensing peaks as tracers of the large-scale structure. We find self-similarity in the void abundance across a range of peak signal-to-noise selection thresholds. The voids obtained via this approach give a tangential shear signal up to ∼40 times larger than voids identified in the galaxy distribution

Anti-oesophageal cancer activity in extracts of deep-water Marion Island sponges

Oesophageal cancer is one of the most common causes of cancer-related deaths in South African black males. The limited efficacy of chemotherapeutic agents to treat this disease has prompted a search for potential new chemical entities with anticancer properties. We report here on the evidence for anti-oesophageal cancer activity in the methanolic extracts of five species of sponges dredged from a depth of approximately 100 m in the vicinity of Marion Island in the Southern Ocean during the autumn of 2004

Anti-oesophageal cancer activity in extracts of deep-water Marion Island sponges

OESOPHAGEAL CANCER IS ONE OF THE most common causes of cancer-related deaths in South African black males. The limited efficacy of chemotherapeutic agents to treat this disease has prompted a search for potential new chemical entities with anticancer properties. We report here on the evidence for anti-oesophageal cancer activity in the methanolic extracts of five species of sponges dredged from a depth of approximately 100 m in the vicinity of Marion Island in the Southern Ocean during the autumn of 2004

Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance

The naked mole-rat (NMR) Heterocephalus glaber is a unique and fascinating mammal exhibiting many unusual adaptations to a subterranean lifestyle. The recent discovery of their resistance to cancer and exceptional longevity has opened up new and important avenues of research. Part of this resistance to cancer has been attributed to the fact that NMRs produce a modified form of hyaluronan—a key constituent of the extracellular matrix—that is thought to confer increased elasticity of the skin as an adaptation for living in narrow tunnels. This so-called high molecular mass hyaluronan (HMM-HA) stems from two apparently unique substitutions in the hyaluronan synthase 2 enzyme (HAS2). To test whether other subterranean mammals with similar selection pressures also show molecular adaptation in their HAS2 gene, we sequenced the HAS2 gene for 11 subterranean mammals and closely related species, and combined these with data from 57 other mammals. Comparative screening revealed that one of the two putatively important HAS2 substitutions in the NMR predicted to have a significant effect on hyaluronan synthase function was uniquely shared by all African mole-rats. Interestingly, we also identified multiple other amino acid substitutions in key domains of the HAS2 molecule, although the biological consequences of these for hyaluronan synthesis remain to be determined. Despite these results, we found evidence of strong purifying selection acting on the HAS2 gene across all mammals, and the NMR remains unique in its particular HAS2 sequence. Our results indicate that more work is needed to determine whether the apparent cancer resistance seen in NMR is shared by other members of the African mole-rat clade.National Research Foundation (South Africa

A Study of the Abrasion of Squeegees Used in Screen Printing and Its Effect on Performance with Application in Printed Electronics

This article presents a novel method for accelerated wear of squeegees used in screen printing and describes the development of mechanical tests which allow more in-depth measurement of squeegee properties. In this study, squeegees were abraded on the screen press so that they could be used for subsequent print tests to evaluate the effect of wear on the printed product. Squeegee wear was found to vary between different squeegee types and caused increases in ink transfer and wider printed features. In production this will lead to greater ink consumption, cost per unit and a likelihood of product failure. This also has consequences for the production of functional layers, etc., used in the construction of printed electronics. While more wear generally gave greater increases in ink deposition, the effect of wear differed, depending on the squeegee. There was a correlation between the angle of the squeegee wear and ink film thickness from a worn squeegee. An ability to resist flexing gave a high wear angle and presented a sharper edge at the squeegee/screen interface thus mitigating the effect of wear. There was also a good correlation between resistance to flexing and ink film thickness for unworn squeegees, which was more effective than a comparison based on Shore A hardness. Squeegee indentation at different force levels gave more information than a standard Shore A hardness test and the apparatus used was able to reliably measure reductions in surface hardness due to solvent absorption. Increases in ink deposition gave lower resistance in printed silver lines; however, the correlation between the amount of ink deposited and the resistance, remained the same for all levels of wear, suggesting that the wear regime designed for this study did not induce detrimental print defects such as line breakages

MGLENS: Modified gravity weak lensing simulations for emulation-based cosmological inference

We present MGLENS, a large series of modified gravity lensing simulations tailored for cosmic shear data analyses and forecasts in which cosmological and modified gravity parameters are varied simultaneously. Based on the FORGE and BRIDGE N-body simulation suites presented in companion papers, we construct 100 × 5000 deg2 of mock Stage-IV lensing data from two 4D Latin hypercubes that sample cosmological and gravitational parameters in f(R) and nDGP gravity, respectively. These are then used to validate our inference analysis pipeline based on the lensing power spectrum, exploiting our implementation of these modified gravity models within the COSMOSIS cosmological inference package. Sampling this new likelihood, we find that cosmic shear can achieve 95 per cent CL constraints on the modified gravity parameters of log10[fR0 ] 0.09, after marginalizing over intrinsic alignments of galaxies and including scales up to = 5000. We also investigate the impact of photometric uncertainty, scale cuts, and covariance matrices. We finally explore the consequences of analysing MGLENS data with the wrong gravity model, and report catastrophic biases for a number of possible scenarios. The Stage-IV MGLENS simulations,the FORGE and BRIDGE emulators and the COSMOSIS interface modules will be made publicly available upon journal acceptance

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression