Erratum: The development of support intuitions and object causality in juvenile Eurasian jays (Garrulus glandarius).

Knowledge about the causal relationship between objects has been studied extensively in human infants, and more recently in adult animals using differential looking time experiments. How knowledge about object support develops in non-human animals has yet to be explored. Here, we studied the ontogeny of support relations in Eurasian jays (Garrulus glandarius), a bird species known for its sophisticated cognitive abilities. Using an expectancy violation paradigm, we measured looking time responses to possible and impossible video and image stimuli. We also controlled for experience with different support types to determine whether the emergence of support intuitions is dependent upon specific interactions with objects, or if reasoning develops independently. At age 9 months, birds looked more at a tool moving a piece of cheese that was not in contact than one that was in direct contact. By the age of 6 months, birds that had not experienced string as a support to hold up objects looked more at impossible images with string hanging from below (unsupported), rather than above (supported). The development of support intuitions may be independent of direct experience with specific support, or knowledge gained from interactions with other objects may be generalised across contexts

Editorial : The Challenges of Interdisciplinary Publishing

Peer reviewedPublisher PD

Sheep Updates 2003 - Meat

This session covers seven papers from different authors: 1. Economic analysis of using terminal sires in a self replacing Merino flock Lucy Anderton, Department of Agriculture Western Australia, Katanning 2. Is the mating of ewe weaners an option for increasing the numbers of lambs in WA? Rob Davidson University of WA, Crawley and Keith Croker Department of Agriculture Western Australia, South Perth 3.Dehydration of lambs at the time of slaughter Robin Jacob, School of Veterinary and Biomedical Sciences, Murdoch University 4.Feeding prime lambs for slaughter Rachel Kirby, Outback Solutions 5. Live sheep export R&D Steve Meerwald, Wellard Rural Exports 6. Confinement feeding sheep in Western Australia John Milton, The University of Western Australia 7. Sheepmeat eating quality - affects of animal age, finishing and processing David Pethick, School of Veterinary and Biomedical Sciences, Murdoch Universit

Clumped stellar winds in supergiant high-mass X-ray binaries: X-ray variability and photoionization

The clumping of massive star winds is an established paradigm confirmed by multiple lines of evidence and supported by stellar wind theory. The purpose of this paper is to bridge the gap between detailed models of inhomogeneous stellar winds in single stars and the phenomenological description of donor winds in supergiant high-mass X-ray binaries (HMXBs). We use results from time-dependent hydrodynamical models of the instability in the line-driven wind of a massive supergiant star to derive the time-dependent accretion rate onto a compact object in the Bondi-Hoyle-Lyttleton approximation. The strong density and velocity fluctuations in the wind result in strong variability of the synthetic X-ray light curves. The model predicts a large scale X-ray variability, up to eight orders of magnitude, on relatively short timescales. The apparent lack of evidence for such strong variability in the observed HMXBs indicates that the details of accretion process act to reduce the variability due to the stellar wind velocity and density jumps. We, also, study the absorption of X-rays in the clumped stellar wind by means of a 2-D stochastic wind model and find that absorption of X-rays changes strongly at different orbital phases. Furthermore, we address the photoionization in the clumped wind, and show that the degree of ionization is affected by the wind clumping. A correction factor for the photoionization parameter is derived. It is shown that the photoionization parameter is reduced by a factor Xi compared to the smooth wind models with the same mass-loss rate, where Xi is the wind inhomogeneity parameter. We conclude that wind clumping must also be taken into account when comparing the observed and model spectra of the photoionized stellar wind.Comment: 12 pages, MNRAS accepte

The economic case for investing in the prevention of mental health conditions in the UK

This report provides an overview of the economic case for the prevention of mental health conditions. To do this, we first estimated the societal costs of living with mental health conditions in the UK in 2019 and then reviewed what is known about the cost-effectiveness of wellevidenced actions to prevent these mental health conditions. To estimate costs, we used a prevalencebased costing approach. This measures the number of people living with mental health conditions over a specific short time period (usually one year) and estimates the average costs associated with these conditions over this time period. Our prevalencebased costing model makes use of data on prevalence from the 2019 Institute of Health Metrics and Evaluation Global Burden of Disease (GBD) study. The GBD study quantifies the impact of all health conditions, both infectious and non-communicable, including mental health conditions, as well as the impacts on injury, including intentional self-harm. As part of the study, the GBD systematically searches for and assesses mental health surveys around the globe. To allow for comparability in measurement, case definitions used by GBD predominantly adhered to international diagnostic criteria guidance, either the DSM-IV-TR, mainly used in the United States or the ICD-10 criteria used mainly elsewhere, as these are used by the majority of mental health surveys included in the GBD. The GBD study estimates are periodically updated, apply a common methodology, are subject to peer review, and are routinely used by the World Health Organization (WHO) when looking at the global impact of mental health conditions. Furthermore, GBD estimates are provided separately for all four nations of the UK, as well as at English Region level. These estimates are conservative, as the GBD does not include the impact of sub-diagnostic threshold mental health conditions, as well as risk factors such as undue stress which do not fit into diagnostic criteria, all of which will also have economic costs. We included 11 of 12 broad categories of mental disorder meeting diagnosable thresholds used in the GBD1. These were depressive disorders (major depressive disorder and dysthymia), anxiety disorders, bipolar affective disorder, schizophrenia, autism spectrum disorders, conduct disorder, attention-deficit hyperactivity disorder (ADHD), eating disorders (anorexia nervosa and bulimia nervosa), and a final category of other mental disorders (which mainly covers personality disorders). A detailed list of conditions is listed in Table A-2 in the appendix. We excluded the idiopathic intellectual disabilities category in the GBD. Neurological conditions such as dementia, as well as alcohol and substance use disorders, are not included. Although not all intentional self-harm is linked with a mental health condition, we also separately provide an estimate of the health and intangible costs associated with intentional self-harm, including suicide, reported in the GBD. All costs are calculated and reported in 2020 pounds sterling

Application of compression bandaging post-osteotomy results in altered pain profile; results of a single-centre randomised controlled trial.

Purpose To assess if application of dual-layer compression bandage to osteotomy patients post-surgery can positively influence levels of post-operative pain and swelling. Patients & Methods Prospective, single-centre, randomised controlled trial comparing standard care, non-compression bandaging, versus Coban™ 2 (3M). Seven day application of the latter to index leg of osteotomy patients. Results Primary outcome data was available for 36 out of 49 study subjects (18 standard care versus 18 Coban™ 2 subjects). Median 10-cm scale pain levels showed a statistically non-significant difference at day 5 and day 12 post-surgery between standard care and Coban™ 2 respectively: 5.5 cm vs 2.5 cm (p-value 0.068) and 4.0 cm vs 2.3 cm (p-value 0.39). However, on day 12 (p-value 0.029) and week 6 (p-value 0.027), ‘throbbing pain’ was significantly higher for Coban™ 2 patients. Changes in limb swelling measures, comparing before and after the surgical procedure, did not differ between treatment arms. Compression led to more patients reporting bandage-related discomfort (6% standard care versus 63% Coban™ 2 patients). Conclusion Compression bandaging changes the post-surgery pain profile in osteotomy patients, but does not reduce leg swelling. Any subsequent leg compression trials must take into account patient comfort and titrate intervention length and compression rates

Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007–2012

BACKGROUND: The incidence of non-tuberculous mycobacteria (NTM) isolation from humans is increasing worldwide. In England, Wales and Northern Ireland (EW&NI) the reported rate of NTM more than doubled between 1996 and 2006. Although NTM infection has traditionally been associated with immunosuppressed individuals or those with severe underlying lung damage, pulmonary NTM infection and disease may occur in people with no overt immune deficiency. Here we report the incidence of NTM isolation in EW&NI between 2007 and 2012 from both pulmonary and extra-pulmonary samples obtained at a population level. METHODS: All individuals with culture positive NTM isolates between 2007 and 2012 reported to Public Health England by the five mycobacterial reference laboratories serving EW&NI were included. RESULTS: Between 2007 and 2012, 21,118 individuals had NTM culture positive isolates. Over the study period the incidence rose from 5.6/100,000 in 2007 to 7.6/100,000 in 2012 (p < 0.001). Of those with a known specimen type, 90 % were pulmonary, in whom incidence increased from 4.0/100,000 to 6.1/100,000 (p < 0.001). In extra-pulmonary specimens this fell from 0.6/100,000 to 0.4/100,000 (p < 0.001). The most frequently cultured organisms from individuals with pulmonary isolates were within the M. avium-intracellulare complex family (MAC). The incidence of pulmonary MAC increased from 1.3/100,000 to 2.2/100,000 (p < 0.001). The majority of these individuals were over 60 years old. CONCLUSION: Using a population-based approach, we find that the incidence of NTM has continued to rise since the last national analysis. Overall, this represents an almost ten-fold increase since 1995. Pulmonary MAC in older individuals is responsible for the majority of this change. We are limited to reporting NTM isolates and not clinical disease caused by these organisms. To determine whether the burden of NTM disease is genuinely increasing, a standardised approach to the collection of linked national microbiological and clinical data is required

Validity of a three-variable juvenile arthritis disease activity score in children with new-onset juvenile idiopathic arthritis

&lt;p&gt;Objectives To investigate the validity and feasibility of the Juvenile Arthritis Disease Activity Score (JADAS) in the routine clinical setting for all juvenile idiopathic arthritis (JIA) disease categories and explore whether exclusion of the erythrocyte sedimentation rate (ESR) from JADAS (the ‘JADAS3’) influences correlation with single markers of disease activity.&lt;/p&gt; &lt;p&gt;Methods JADAS-71, JADAS-27 and JADAS-10 were determined at baseline for an inception cohort of children with JIA in the Childhood Arthritis Prospective Study. JADAS3-71, JADAS3-27 and JADAS3-10 were determined using an identical formula but with exclusion of ESR. Correlation of JADAS with JADAS3 and single measures of disease activity/severity were determined by category.&lt;/p&gt; &lt;p&gt;Results Of 956 eligible children, sufficient data were available to calculate JADAS-71, JADAS-27 and JADAS-10 at baseline in 352 (37%) and JADAS3 in 551 (58%). The median (IQR) JADAS-71, JADAS-27 and JADAS-10 for all 352 children was 11 (5.9–18), 10.4 (5.7–17) and 11 (5.9–17.3), respectively. Median JADAS and JADAS3 varied significantly with the category (Kruskal–Wallis p=0.0001), with the highest values in children with polyarticular disease patterns. Correlation of JADAS and JADAS3 across all categories was excellent. Correlation of JADAS71 with single markers of disease activity/severity was good to moderate, with some variation across the categories. With the exception of ESR, correlation of JADAS3-71 was similar to correlation of JADAS-71 with the same indices.&lt;/p&gt; &lt;p&gt;Conclusions This study is the first to apply JADAS to all categories of JIA in a routine clinical setting in the UK, adding further information about the feasibility and construct validity of JADAS. For the majority of categories, clinical applicability would be improved by exclusion of the ESR.&lt;/p&gt