888 research outputs found
Network synchronization: Optimal and Pessimal Scale-Free Topologies
By employing a recently introduced optimization algorithm we explicitely
design optimally synchronizable (unweighted) networks for any given scale-free
degree distribution. We explore how the optimization process affects
degree-degree correlations and observe a generic tendency towards
disassortativity. Still, we show that there is not a one-to-one correspondence
between synchronizability and disassortativity. On the other hand, we study the
nature of optimally un-synchronizable networks, that is, networks whose
topology minimizes the range of stability of the synchronous state. The
resulting ``pessimal networks'' turn out to have a highly assortative
string-like structure. We also derive a rigorous lower bound for the Laplacian
eigenvalue ratio controlling synchronizability, which helps understanding the
impact of degree correlations on network synchronizability.Comment: 11 pages, 4 figs, submitted to J. Phys. A (proceedings of Complex
Networks 2007
How different are the visual representations used for object recognition in middle childhood and adulthood?
Recent experimental studies have shown that development towards adult performance levels in configural processing in object recognition is delayed through middle childhood. Whilst partchanges to animal and artefact stimuli are processed with similar to adult levels of accuracy from 7 years of age, relative size changes to stimuli result in a significant decrease in relative performance for participants aged between 7 and 10. Two sets of computational experiments were run using the JIM3 artificial neural network with adult and 'immature' versions to simulate these results. One set progressively decreased the number of neurons involved in the representation of view-independent metric relations within multi-geon objects. A second set of computational experiments involved decreasing the number of neurons that represent view-dependent (nonrelational) object attributes in JIM3's Surface Map. The simulation results which show the best qualitative match to empirical data occurred when artificial neurons representing metric-precision relations were entirely eliminated. These results therefore provide further evidence for the late development of relational processing in object recognition and suggest that children in middle childhood may recognise objects without forming structural description representations
Echocardiographic assessment of patients with infectious endocarditis: Prediction of risk for complications
AbstractTo enhance the echocardiographic identification of high risk lesions in patients with infectious endocarditis, the medical records and two-dimensional echocardiograms of 204 patients with this condition were analyzed. The occurrence of specific clinical complications was recorded and vegetations were assessed with respect to predetermined morphologic characteristics.The overall complication rates were roughly equivalent for patients with mitral (53%), aortic (62%), tricuspid (77%) and prosthetic valve (61%) vegetations, as well as for those with nonspecific valvular changes but no discrete vegetations (57%), although the distribution of specific complications varied considerably among these groups. There were significantly fewer complications in patients without discernible valvular abnormalities (27%).In native left-sided valve endocarditis, vegetation size, extent, mobility and consistency were all found to be significant univariate predictors of complications. In multivariate analysis, vegetation size, extent and mobility emerged as optimal predictors and an echocardiographic score based on these factors predicted the occurrence of complications with 70% sensitivity and 92% specificity in mitral valve endocarditis and with 76% sensitivity and 62% specificity in aortic valve endocarditis
Quantum graphs where back-scattering is prohibited
We describe a new class of scattering matrices for quantum graphs in which
back-scattering is prohibited. We discuss some properties of quantum graphs
with these scattering matrices and explain the advantages and interest in their
study. We also provide two methods to build the vertex scattering matrices
needed for their construction.Comment: 15 page
Optimal network topologies: Expanders, Cages, Ramanujan graphs, Entangled networks and all that
We report on some recent developments in the search for optimal network
topologies. First we review some basic concepts on spectral graph theory,
including adjacency and Laplacian matrices, and paying special attention to the
topological implications of having large spectral gaps. We also introduce
related concepts as ``expanders'', Ramanujan, and Cage graphs. Afterwards, we
discuss two different dynamical feautures of networks: synchronizability and
flow of random walkers and so that they are optimized if the corresponding
Laplacian matrix have a large spectral gap. From this, we show, by developing a
numerical optimization algorithm that maximum synchronizability and fast random
walk spreading are obtained for a particular type of extremely homogeneous
regular networks, with long loops and poor modular structure, that we call
entangled networks. These turn out to be related to Ramanujan and Cage graphs.
We argue also that these graphs are very good finite-size approximations to
Bethe lattices, and provide almost or almost optimal solutions to many other
problems as, for instance, searchability in the presence of congestion or
performance of neural networks. Finally, we study how these results are
modified when studying dynamical processes controlled by a normalized (weighted
and directed) dynamics; much more heterogeneous graphs are optimal in this
case. Finally, a critical discussion of the limitations and possible extensions
of this work is presented.Comment: 17 pages. 11 figures. Small corrections and a new reference. Accepted
for pub. in JSTA
Priming of plane-rotated objects depends on attention and view familiarity
Three experiments investigated the role of attention in visual priming across rotations in the picture plane. Experiment 1 showed that naming latencies increased with the degree of misorientation for objects commonly seen in an upright view (base objects) but not for objects seen familiarly from many views (no-base objects). In Experiment 2, no-base objects revealed a priming pattern identical to that observed previously for left-right reflections (Stankiewicz, Hummel, & Cooper, 1998): Attended objects primed themselves in the same and rotated views, whereas ignored images primed themselves only in the same view, with additive effects of attention and orientation. In Experiment 3 ignored base objects only primed themselves in a familiar (upright) view, indicating that priming only obtains when that image makes contact with object memory. These data challenge theories of object recognition that rely on any single representation of shape and contribute to evidence suggesting holistic (view-like) representations for ignored and analytic (view-insensitive) representations for attended objects
RAMESES publication standards: realist syntheses
PMCID: PMC3558331This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Serum antibodies against p53 in relation to cancer risk and prognosis in breast cancer: a population-based epidemiological study
To perform an epidemiological evaluation of the predictive value of p53 autoantibodies in breast cancer, we measured antibodies against p53 in serum samples from 165 breast cancer patients in comparison with serum samples from 330 healthy controls, selected from the same population as the cases and matched for age, sex and specimen storage time. Median age of patients was 51 years (range 25–64 years). Presence of serum p53 autoantibodies was analysed by enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blotting. The lower ELISA reactivities were similar for cases and controls, but presence of high-level reactivity was more common among cases than among controls [odds ratio (OR) 9.03, 95% confidence interval (CI) 2.40–50.43]. Presence of Western blot-detected p53 autoantibodies had a very similar association (OR 10.8, CI 3.0–59.4). Among the cases, we also studied whether there was any correlation between level of anti-p53 antibodies and stage of the disease or survival. There was no significant correlation between presence of antibodies and stage of the disease. There was a significant negative correlation between presence of p53 antibodies and survival (P= 0.003). A stepwise multivariate Cox regression analysis showed that T-stage, age and presence of anti-p53 antibodies were significant independent prognostic variables, with a dose-dependent negative effect on survival for all three variables. We conclude that presence of anti-p53 antibodies are of significance both for the risk of having breast cancer and the risk of dying from breast cancer. 1999 Cancer Research Campaig
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