7 research outputs found
Analysis of the Mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer
- Author
- B Derijard
- BA Yoshida
- BG Ward
- D Etemadmoghadam
- D Yang
- David YH Choong
- DH Teng
- Georgina L Ryland
- GL Johnson
- Ian G Campbell
- J Ziauddin
- JL Bearfoot
- K Nakayama
- KJ Simpson
- KL Gorringe
- KL Gorringe
- Kylie L Gorringe
- L Chang
- L Wang
- M Ramakrishna
- MA Spillman
- Manasa Ramakrishna
- ON Ikediobi
- R Beroukhim
- R Mullenbach
- RJ Davis
- RJ Leary
- RW Tothill
- S Rozen
- S Yeasmin
- Sally J Davis
- SD Yamada
- SW Tsao
- T Sjoblom
- X Xu
- YT Ip
- Z Kan
- Z Xia
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p><it>MAP2K4 </it>is a putative tumor and metastasis suppressor gene frequently found to be deleted in various cancer types. We aimed to conduct a comprehensive analysis of this gene to assess its involvement in ovarian cancer.</p> <p>Methods</p> <p>We screened for mutations in <it>MAP2K4 </it>using High Resolution Melt analysis of 149 primary ovarian tumors and methylation at the promoter using Methylation-Specific Single-Stranded Conformation Polymorphism analysis of 39 tumors. We also considered the clinical impact of changes in <it>MAP2K4 </it>using publicly available expression and copy number array data. Finally, we used siRNA to measure the effect of reducing <it>MAP2K4 </it>expression in cell lines.</p> <p>Results</p> <p>In addition to 4 previously detected homozygous deletions, we identified a homozygous 16 bp truncating deletion and a heterozygous 4 bp deletion, each in one ovarian tumor. No promoter methylation was detected. The frequency of <it>MAP2K4 </it>homozygous inactivation was 5.6% overall, and 9.8% in high-grade serous cases. Hemizygous deletion of <it>MAP2K4 </it>was observed in 38% of samples. There were significant correlations of copy number and expression in three microarray data sets. There was a significant correlation between <it>MAP2K4 </it>expression and overall survival in one expression array data set, but this was not confirmed in an independent set. Treatment of JAM and HOSE6.3 cell lines with <it>MAP2K4 </it>siRNA showed some reduction in proliferation.</p> <p>Conclusions</p> <p><it>MAP2K4 </it>is targeted by genetic inactivation in ovarian cancer and restricted to high grade serous and endometrioid carcinomas in our cohort.</p
EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer
- Author
- Amanda J Russell
- Colin KW Watts
- Davendra Segara
- David W Anderson
- David YH Choong
- Erica Woollatt
- Ged Brady
- Graeme A Macdonald
- Graham J Mann
- Ian G Campbell
- Jennifer L Clancy
- Michael J Davies
- Michelle J Henderson
- Neville F Hacker
- Olufunmilayo I Olopade
- RL Sutherland
- Robert L Sutherland
- Ronaldo J Bova
- Susan M Henshall
- Tania Nolan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/08/2003
- Field of study
EDD (E3 isolated by differential display), located at chromosome 8q22.3, is the human orthologue of the Drosophila melanogaster tumour suppressor gene 'hyperplastic discs' and encodes a HECT domain E3 ubiquitin protein-ligase. To investigate the possible involvement of EDD in human cancer, several cancers from diverse tissue sites were analysed for allelic gain or loss (allelic imbalance, AI) at the EDD locus using an EDD-specific microsatellite, CEDD, and other polymorphic microsatellites mapped in the vicinity of the 8q22.3 locus. Of 143 cancers studied, 38 had AI at CEDD (42% of 90 informative cases). In 14 of these cases, discrete regions of imbalance encompassing 8q22.3 were present, while the remainder had more extensive 8q aberrations. AI of CEDD was most frequent in ovarian cancer (22/47 informative cases, 47%), particularly in the serous subtype (16/22, 73%), but was rare in benign and borderline ovarian tumours. AI was also common in breast cancer (31%), hepatocellular carcinoma (46%), squamous cell carcinoma of the tongue (50%) and metastatic melanoma (18%). AI is likely to represent amplification of the EDD gene locus rather than loss of heterozygosity, as quantitative RT-PCR and immunohistochemistry showed that EDD mRNA and protein are frequently overexpressed in breast and ovarian cancers, while among breast cancer cell lines EDD overexpression and increased gene copy number were correlated. These results demonstrate that AI at the EDD locus is common in a diversity of carcinomas and that the EDD gene is frequently overexpressed in breast and ovarian cancer, implying a potential role in cancer progression
Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer
- Author
- A Miron
- A Petitjean
- A Untergasser
- A Yemelyanova
- Alexander Dobrovic
- AM Marquard
- Andrew P Fellowes
- C Curtis
- C Soon Lee
- Cancer Genome Atlas N
- Chelsee Hewitt
- David J Byrne
- David YH Choong
- DC Ang
- E Cerami
- Elena A Takano
- Ewan KA Millar
- G Bruce Mann
- Gisela Mir Arnau
- GP Pfeifer
- GR Abecasis
- H Li
- H Li
- Ian G Campbell
- J Dunlap
- J Usary
- JD Stender
- Jia-Min B Pang
- JM Arnold
- JM Pang
- K Gorringe
- K Kalinsky
- KA Janes
- KE Munn
- KL Gorringe
- Kylie L Gorringe
- LB Alexandrov
- M Chitemerere
- Margaret C Cummings
- MC Abba
- MJ Ellis
- NJ Birkbak
- P Kumar
- Peter Savas
- PJ Stephens
- RA Sakr
- Ravikiran Vedururu
- S Banerji
- S Loi
- S Nik-Zainal
- Sandra A O'Toole
- Sherene Loi
- SJ Done
- SJ Zardawi
- SQ Wong
- Stephen B Fox
- Sunil R Lakhani
- SY Kim
- T Koressaar
- T Kuilman
- Tanjina Kader
- W Zhou
- X Mao
- Y Choi
- YZ Jiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry
- Author
- Abban Dzifa Wosornu
- Abdul Nasser
- Abud Atilio Marcelo
- Adams Fran
- Addala Srinivas
- Adragão Pedro
- Ageno Walter
- Aggarwal Rajesh
- Agosti Sergio
- Agostoni Piergiuseppe
- Aguilar Francisco
- Aguinaga Luis
- Ahmed Jameel
- Aiello Allessandro
- Ainsworth Paul
- Aiub Jorge Roberto
- Al-Dallow Raed
- Alderson Lisa
- Aldrete Velasco Jorge Antonio
- Alexopoulos Dimitrios
- Aliyar Pareed
- Almeida Luísa Fonseca
- Alonso David
- Alves da Costa Fernando Augusto
- Amado José
- Amara Walid
- Amelot Mathieu
- Amjadi Nima
- Ammirati Fabrizio
- Andrade Marianna
- Andrawis Nabil
- Angela Koh Su Mei
- Annoni Giorgio
- Ansalone Gerardo
- Ariani M Kevin
- Arias Juan Carlos
- Armero Sébastien
- Arora Chander
- Asensi Joaquín Osca
- Aslam Muhammad Shakil
- Asselman M
- Audouin Philippe
- Augenbraun Charles
- Aydin S
- Ayryanova Ivaneta
- Aziz Emad
- Backes Luciano Marcelo
- Badings E
- Bagni Ermentina
- Baker Seth H
- Bala Richard
- Baldi Antonio
- Bando Shigenobu
- Banerjee Subhash
- Bank Alan
- Barr Craig
- Bartlett Maria
- Baula Giovanni
- Behrens Steffen
- Bell Alan
- Benedetti Raffaella
- Benhalima Bouziane
- Berg JM ten
- Bergler-Klein Jutta
- Berneau Jean-Baptiste
- Bernstein Richard A
- Berrospi Percy
- Berti Sergio
- Berz Andrea
- Best Elizabeth
- Bettencourt Paulo
- Betzu Robert
- Bhagwat Ravi
- Bhatta Luna
- Biscione Francesco
- Bisignani Giovanni
- Bisson Arnaud
- Black Toby
- Bloch Michael J
- Bloom Stephen
- Blumberg Edwin
- Bo Mario
- Bodes Rafael Salguero
- Bollmann Andreas
- Bongiorni Maria Grazia
- Boriani Giuseppe
- Boriani Giuseppe
- Boswijk DJ
- Bott Jochen
- Bottacchi Edo
- Bradman Drew
- Brautigam Donald
- Breton Nicolas
- Briones Ignacio Rodriguez
- Brkljacic Diana Delic
- Brouwers PJAM
- Browne Kevin
- Bruni A
- Brunschwig Claude
- Bryan Yan Ping Yen
- Buathier Hervé
- Buenostro Gabriel Contreras
- Buhl Aurélie
- Bullinga John
- Bøhmer Ellen
- Cabrera Jose Walter
- Caccavo Alberto
- Cai Shanglang
- Caine Sarah
- Calvi Valeria
- Calò Leonardo
- Campos Rodrigo Noronha
- Candeias Rui
- Capuano Vincenzo
- Capucci Alessandro
- Caputo Ronald
- Cardona Francisco
- Carlos da Costa Darrieux Francisco
- Carolei Antonio
- Carreño Susana
- Carvalho Paula
- Cary Susanna
- Casu Gavino
- Cavallini Claudio
- Cayla Guillaume
- Celentano Aldo
- Cha Kwang Soo
- Cha Tae-Joon
- Chae Jei Keon
- Chalamidas Kathrine
- Challappa Krishnan
- Chan Yi-Hsin
- Chand Sunil Prakash
- Chandrashekar Harinath
- Chao Tze-Fan
- Chartier Ludovic
- Chatterjee Kausik
- Chavez Ayala Carlos Antero
- Cheema Aamir
- Cheema Amjad
- Chen Jyh Hong
- Chen Lin
- Chen Shih-Ann
- Chiang Fu-Tien
- Chiarella Francesco
- Chih-Chan Lin
- Cho Yong Keun
- Choi Dong Ju
- Choi Jong-Il
- Chouinard Guy
- Chreih Rami Mihail
- Chrysos Dimitrios
- Chumakova Galina
- Cislowski David J
- Clay Anthony
- Clifford Piers
- Cohen Andrew
- Cohen Michael
- Cohen Serge
- Colivicchi Furio
- Collins Ronan
- Colonna Paolo
- Compton Steve
- Connolly Derek
- Conti Alberto
- Coodley Gregg
- Cooper Martin
- Corica Bernadette
- Coronel Julian
- Corso Giovanni
- Cortada Jordi Bruguera
- Cottin Yves
- Covalesky John
- Cracan Aurel
- Crea Filippo
- Crean Peter
- Crenshaw James
- Cristian Nechita Alexandru
- Cullen Tina
- D'Souza Anthony
- Dahl Jürgen vom
- Darius Harald
- Dary Patrick
- Dascotte Olivier
- Dauber Ira
- Davalos Vicente
- Davies Ruth
- Davis Gershan
- Davy Jean-Marc
- Dayer Mark
- De Biasio Marzia
- De Bonis Silvana
- De Caterina Raffaele
- De Franceschi Teresiano
- de Groot JR
- De Horta José
- De La Briolle Axel
- de Souza Weimar
- de Veer A
- De Wolf Luc
- Decoulx Eric
- Deepak Sasalu
- Defaye Pascal
- Del-Carpio Munoz Freddy
- Deumite N Joseph
- Di Legge Silvia
- Diemberger Igor
- Dietz Denise
- Dionísio Pedro
- Dong Qiang
- Dotcheva Elena
- Doukky Rami
- Duarte Vera Yan Carlos
- Dubrey Simon
- Ducrocq Xavier
- Dupljakov Dmitry
- Duque Mauricio
- Dutta Dipankar
- Duvilla Nathalie
- Duygun A
- Dziewas Rainer
- Eaton Charles B
- Eaves William
- Ebels-Tuinbeek
- Eichinger-Hasenauer Sabine
- Eisenberg Steven J
- El Jabali Adnan
- El Shahawy Mahfouz
- Esperon Guillermo Llamas
- Esquivias Gonzalo Barón
- Evonich Rudolph
- Evseeva Oksana
- Ezhov Andrey
- Fahmy Raed
- Fang Quan
- Farsad Ramin
- Fauchier Laurent
- Favale Stefano
- Fayard Maxime
- Fedele Francesco
- Fedele Jose Luis
- Fedorishina Olga
- Fera Steven R
- Fernández Marcelo Sanmartín
- Ferreira de Souza Olga
- Ferreira Jorge
- Ferri Claudio
- Ferrier Anna
- Ferro Hugo
- Figueiredo Estêvão Lanna
- Filho Dario Sobral
- Finsen Alexandra
- First Brian
- Fischer Stuart
- Fonseca Catarina
- Forman Steven
- Frandsen Brad
- French William
- Friedman Keith
- Friese Athena
- Fruntelata Ana Gabriela
- Frydenlund Juliane
- Fujii Shigeru
- Fumagalli Stefano
- Fundamenski Marta
- Furukawa Yutaka
- Gabelmann Matthias
- Gabra Nashwa
- Gadsbøll Niels
- Galinier Michel
- Gammelgaard Anders
- Ganeshkumar Priya
- Gans Christopher
- Garcéa Jose Polo
- Gartenlaub Olivier
- Gaspardone Achille
- Genz Conrad
- Georger Frédéric
- Georges Jean-Louis
- Georgeson Steven
- Giedrimas Evaldas
- Gierba Mariusz
- Gillespie Eve
- Giniger Alberto
- Giudici Michael C
- Gkotsis Alexandros
- Glotzer Taya V
- Gmehling Joachim
- Gniot Jacek
- Goethals Peter
- Goldbarg Seth
- Goldberg Ronald
- Goldmann Britta
- Golitsyn Sergey
- Gomes Ferreira Luis Gustavo
- Gonzalez Hermosillo Jesus Antonio
- Gonzalez Vicente Bertomeu
- González López Víctor Manuel
- González Salvador León
- Gorka Hervé
- Gornick Charles
- Gorog Diana
- Gottipaty Venkat
- Goube Pascal
- Goudevenos Ioannis
- Graham Brett
- Greer G Stephen
- Gremmler Uwe
- Grena Paul G
- Grond Martin
- Gronda Edoardo
- Grönefeld Gerian
- Gu Xiang
- Guardigli Gabriele
- Guevara Carolina
- Guignier Alexandre
- Gulizia Michele
- Gumbley Michael
- Gómez Silvia
- Günther Albrecht
- Ha Andrew
- Hahalis Georgios
- Hakas Joseph
- Hall Christian
- Han Bing
- Han Seongwook
- Hargrove Joe
- Hargroves David
- Harris Kenneth B
- Haruna Tetsuya
- Hayek Emil
- Healey Jeff
- Hearne Steven
- Heffernan Michael
- Heggelund Geir
- Heijmeriks JA
- Hemels Maarten
- Hendriks I
- Henein Sam
- Her Sung-Ho
- Hermany Paul
- Hernandes Mauro Esteves
- Hernandez Norberto Matadamas
- Hernández Del Río Jorge Eduardo
- Higashino Yorihiko
- Hill Michael
- Hisadome Tetsuo
- Hishida Eiji
- Hoffer Etienne
- Hoghton Matthew
- Hoi-Fan Chow Danny
- Hong Kui
- Hong Suk keun
- Horbach Stevie
- Horiuchi Masataka
- Hou Yinglong
- Hsing Jeff
- Huang Chi-Hung
- Huckins David
- Hughes kathy
- Huisman Menno V
- Huizinga A
- Hulsman EL
- Hung Kuo-Chun
- Hwang Gyo-Seung
- Ikpoh Margaret
- Imberti Davide
- Ince Hüseyin
- Indolfi Ciro
- Inoue Shujiro
- Irles Didier
- Iseki Harukazu
- Israel C Noah
- Iteld Bruce
- Iyer Venkat
- Izal Ana Etxeberria
- Jackson-Voyzey Ewart
- Jaffrani Naseem
- James Martin
- Jang Sung-Won
- Jaramillo Nicolas
- Jarmukli Nabil
- Jattin Fernando Manzur
- Jeanfreau Robert J
- Jenkins Ronald D
- Jimenez Javier
- Jimenez Ricardo Pavón
- Jobe Robert
- Joen-Jakobsen Tomas
- Jones Nicholas
- Jose eena Padayattil
- José Roberto Eduardo Julián
- Jouve Bernard
- Jung Byung Chun
- Jung Kyung Tae
- Jung Werner
- Jäger Frank
- Kachkovskiy Mikhail
- Kafkala Krystallenia
- Kalan Marica Bracic
- Kalinina Larisa
- Kallmünzer Bernd
- Kamali Farzan
- Kamo Takehiro
- Kampus Priit
- Karla Kurrelmeyer
- Kashou Hisham
- Kastrup Andreas
- Katsivas Apostolos
- Kaufman Elizabeth
- Kawai Kazuya
- Kawajiri Kenji
- Kazmierski John F
- Keeling P
- Kerr Saraiva José Francisco
- Kes Vanja Basic
- Ketova Galina
- Khaira Ajit Singh
- Khripun Aleksey
- Kim Dae Kyeong
- Kim Doo-Il
- Kim Jeong Su
- Kim Jin bae
- Kim June Soo
- Kim Ki Seok
- Kim Nam Ho
- Kim Young Hoon
- Kinova Elena
- Klein Alexander
- Kmetzo James J
- Kneller G Larsen
- Knezevic Aleksandar
- Koide Shunichi
- Kollias Anastasios
- Kooistra JA
- Koons Jay
- Koschutnik Martin
- Kostis William J
- Kovacic Dragan
- Kowalczyk Jacek
- Koziolova Natalya
- Kraft Peter
- Kragten Johannes A
- Krantz Mori
- Krause Lars
- Krenning BJ
- Krikke F
- Kromhout Z
- Krysiak Waldemar
- Kumar Priya
- Kuniss Malte
- Kuo Jen-Yuan
- Kwak Choong Hwan
- Kümler Thomas
- Küppers Achim
- Laboulle Bénédicte
- Labovitz Arthur
- Lai Wen Ter
- Lam Andy
- Lam Yat Yin
- Landau Charles
- Landini Giancarlo
- Larsen Torben
- Lavandier Karine
- Lawrence Wong Ka Sing
- LeBlanc Jessica
- Lee Chang-Hoon
- Lee Moon Hyoung
- Lehman John
- Leitão Ana
- Lellouche Nicolas
- Lelonek Malgorzata
- Lenarczyk Radoslaw
- Lenderink T
- Leong-Sit Peter
- Leschke Matthias
- Ley Nicolas
- Li Weihua
- Li Xiaodong
- Li Xiaoming
- Li Zhanquan
- Lichy Christhoh
- Lieber Ira
- Limon Rodriguez Ramon Horacio
- Lin Hailong
- Linares Julio Aguilar
- Lip Gregory YH
- Lip Gregory YH
- Liu Feng
- Liu Hengliang
- Lo Eric
- Lokshyn Sergiy
- Lorga Filho Adalberto Menezes
- Lorraine Richard S
- Luengas Carlos Alberto
- Luke Robert
- Luo Ming
- Lupovitch Steven
- Lyrer Philippe
- López Amador
- López-Sendón José Luís
- Ma Changsheng
- Ma Genshan
- Madariaga Irene
- Maeno Koji
- Magnin Dominique
- Maid Gustavo
- Mainigi Sumeet K
- Makaritsis Konstantinos
- Malhotra Rohit
- Manning Rickey
- Manolis Athanasios
- Manrique Hurtado Helard Andres
- Mantas Ioannis
- Manterola Fernando Alfonso
- Maqueda Vicky
- Marchionni Niccolo
- Martinez Jorge
- Maskova Petra
- Matsuda Katsuhiro
- Maurer Tillmann
- Mauro Ciro
- May Erik
- Mayer Nolan
- Mazuecos Juan Benezet
- McClure John
- McCormack Terry
- McGarity William
- McIntyre Hugh
- McLaurin Brent
- Medina Palomino Feliz Alvaro
- Mei Davide Antonio
- Melandri Francesco
- Meno Hiroshi
- Menzies Dhananjai
- Mercader Marco
- Mesa Juan Gomez
- Meyer Beat J
- Meyer Christian
- Miarka Jacek
- Mibach Frank
- Michalski Dominik
- Michel Patrik
- Miguel Ricardo Nicolás
- Mikdadi Ghiath
- Mikus Milan
- Milicic Davor
- Militaru Constantin
- Minaie Sedi
- Minescu Bogdan
- Mintale Iveta
- Mirault Tristan
- Mirro Michael J
- Mistry Dinesh
- Miu Nicoleta Violeta
- Miyamoto Naomasa
- Miño
- Moccetti Tiziano
- Mohammed Akber
- Mollerus Michael
- Molon Giulio
- Mondillo Sergio
- Moniz Patrícia
- Mont Lluis
- Montagud Vicente
- Montaña Oscar
- Monti Cristina
- Moretti Luciano
- Mori Kiyoo
- Moriarty Andrew
- Morka Jacek
- Moschini Luigi
- Moschos Nikitas
- Moura Jorge Jose Carlos
- Mulhearn Thomas J
- Muresan Carmen
- Muriago Michela
- Musial Wlodzimierz
- Musser Carl W
- Musumeci Francesco
- Mügge Andreas
- Nageh Thuraia
- Nakagawa Hidemitsu
- Nakamura Yuichiro
- Nakayama Toru
- Nam Gi-Byoung
- Nanna Michele
- Natarajan Indira
- Navarro Nassip Llerena
- Nayak Hemal M
- Naydenov Stefan
- Nazlić Jurica
- Nechvatal Libor
- Negron Sandra Adela
- Neiman James
- Neuenschwander Fernando Carvalho
- Neves David
- Neykova Anna
- Nica Nicoleta Cindea
- Nijmeh George
- Nizov Alexey
- Nor Azlisham Mohd
- Nossan Janko
- Novikova Tatiana
- Nowalany-Kozielska Ewa
- Nsah Emmanuel
- Nunez Fragoso Juan Carlos
- Nurgalieva Svetlana
- Nuyens Dieter
- Nyvad Ole
- O'Donnell Martin
- O'Donnell Philip
- O'Hara Gilles
- Odin de Los Rios Ibarra Manuel
- Oh Dongjin
- Oh Seil
- Oh Yong Seog
- Oi Yan Yannie Soo
- Oikonomou Kostas
- Olivares Claudia
- Oliver Richard
- Olshansky Brian
- Olympios Christoforos
- omaszuk-Kazberuk Anna
- Ortega Ignacio Gil
- Ortuno Francisco Marin
- Padilla Padilla Francisco Gerardo
- Pajes Giuseppe
- Pandey Shekhar
- Paparella Gaetano
- Paris F
- Park Hyung Wook
- Park Jong Sung
- Parthenakis Fragkiskos
- Pascual Carlos Rodríguez
- Passamonti Enrico
- Patel Jaydutt
- Patel Mehool
- Patel Rajesh J
- Patrick Janice
- Paz Analía
- Pengo Vittorio
- Pentz William
- Perlman Richard
- Persic Viktor
- Perticone Francesco
- Peters Terri K
- Petkar Sanjiv
- Pezo Luis Felipe
- Pflücke Christian
- Pham David N
- Phillips Roland T
- Phlaum Stephen
- Pieters Denis
- Pineau Julien
- Pinter Arnold
- Pinto Fausto
- Pisters R
- Pivac Nediljko
- Pocanic Darko
- Podoleanu Cristian
- Politano Alessandro
- Poljakovic Zdravka
- Pollock Stewart
- Poppert Holger
- Porcu Maurizio
- Prasad Neeraj
- Prelle Alessandro
- Prodafikas John
- Proietti Marco
- Protasov Konstantin
- Précoma Dalton Bertolim
- Pye Maurice
- Pérez Ríos Alma Minerva
- Pérez Beatriz
- Pérez-Cabezas Alejandro
- Qiu Zhaohui
- Quedillac Jean-Michel
- Quintana Antonio Garcia
- Raev Dimitar
- Raffo Grado Carlos Antonio
- Rahimi Sidiqullah
- Raisaro Arturo
- Rama Bhola
- Ramos Ricardo
- Ranieri Maria
- Raposo Nuno
- Rashba Eric
- Rauch-Kroehnert Ursula
- Reddy Ramakota
- Reino Antonio Pose
- Renda Giulia
- Reza Shabbir
- Ria Luigi
- Richter Dimitrios
- Rickli Hans
- Rieker Werner
- Rios Victoria Padilla
- Ritt Luiz Eduardo
- Rizo Tatiana Cárdenas
- Roberts Douglas
- Rodriguez Escudero Aldo Edwin
- Roman Mark
- Romeo Francesco
- Romiti Giulio Francesco
- Ronner E
- Rossi dos Santos Fabio
- Roux Jean-Francois
- Rozkova Nadezda
- Rubacek Miroslav
- Rubalcava Frank
- Ruiz Rafael Olvera
- Russo Andrea M
- Rutgers Matthieu Pierre
- Rybak Karin
- Said Samir
- Sakamoto Tamotsu
- Salacata Abraham
- Salem Adrien
- Sales Juan Cosín
- Saltzman Marco A
- Salvioni Alessandro
- Santana Antonio Martín
- Saporito Wladmir Faustino
- Sarikonda Kesari
- Sasaoka Taishi
- Sati Hamdi
- Savelieva Irina
- Scala Pierre-Jean
- Schellinger Peter
- Scherr Carlos
- Schmitz Bettina
- Schmitz Karl-Heinz
- Schmitz Lisa
- Schnabel Teresa
- Schnupp Steffen
- Schoeniger Peter
- Schwimmbeck Peter
- Schön Norbert
- Seamark Clare
- Searles Greg
- Seidl Karl-Heinz
- Seidman Barry
- Sek Jaroslaw
- Sekaran Lakshmanan
- Serrati Carlo
- Shah Anil
- Shah Neerav
- Shah Shujahat
- Shah Vinay
- Sharma Vijay Kumar
- Shaw Louise
- Sheikh Khalid H
- Shimizu Naruhito
- Shimomura Hideki
- Shin Dong-Gu
- Shin Eun-Seok
- Shite Junya
- Sibilio Gerolamo
- Silver Frank
- Sime Iveta
- Simmers Tim A
- Singh Takhar Amrit Pal
- Singh Narendra
- Siostrzonek Peter
- Smadja Didier
- Smith David W
- Snitman Marcelo
- Soda Hassan
- Sofley Carl
- Sokal Adam
- Sotolongo Rodolfo
- Sparby Jon Arne
- Spinar Jindrich
- Sprigings David
- Spyropoulos Alex C
- Stakos Dimitrios
- Steinwender Clemens
- Stergiou Georgios
- Stiell Ian
- Stoddard Marcus
- Stoikov Anastas
- Streb Witold
- Styliadis Ioannis
- Su Guohai
- Su Xi
- Sudnik Wanda
- Sukles Kai
- Sun Xiaofei
- Swart H
- Szavits-Nossan Janko
- Sánchez Carlos Jerjes
- Sánchez Mauricio Camarillo
- Taggeselle Jens
- Takagi Yuichiro
- Tamm Angelika
- Tanaka Katsumi
- Tanawuttiwat Tanyanan
- Tang Aylmer
- Tang Sherman
- Tarsi Giovanni
- Tassinari Tiziana
- Tayal Ashis
- Tayebjee Muzahir
- Tesloianu Dan
- The Salem HK
- Thomas Dierk
- Timsit Serge
- Tobaru Tetsuya
- Tomasik Andrzej R
- Topete Gilberto de la Pena
- Torosoff Mikhail
- Torres Torres Ivett Guadalupe
- Touze Emmanuel
- Trendafilova Elina
- Tsai W Kevin
- Tse Hung Fat
- Tsutsui Hiroshi
- Tu Tian Ming
- Tuininga Ype
- Turakhia Minang
- Turk Samir
- Turner Wayne
- Tveit Arnljot
- Tytus Richard
- Valadão C
- Valenzuela Chuquiure
- Vallejo Gregorio Sanchez
- van Bergen PFMM
- van de Borne Philippe
- van den Berg BJ
- van der Zwaan C
- Van Eck M
- Vanacker Peter
- Vasilev Dimo
- Vasilikos Vasileios
- Vasilyev Maxim
- Veerareddy Srikar
- Vera Tomas Ripolil
- Verdecchia Paolo
- Versaci Francesco
- Vester Ernst Günter
- Vial Hubert
- Vicenzo de Paola Angelo Amato
- Victory Jason
- Villamil Alejandro
- Vincent Marc
- Vlastaris Anthony
- Vora Kishor
- Vranian Robert B
- Wakefield Paul
- Wang Feng
- Wang Mingsheng
- Wang Ningfu
- Wang Tian
- Wang Xinhua
- Warner Alberta L
- Watanabe Kouki
- Wei Jeanne
- Weimar Christian
- Weiner Stanislav
- Weinrich Renate
- Wen Ming-Shien
- Wiemer Marcus
- Wiggers Preben
- Wilke Andreas
- Williams David
- Williams Marcus L
- Witzenbichler Bernhard
- Wong Brian
- Wozakowska-Kaplon Beata
- Wu Richard C
- Wu Shulin
- Wunderlich Silke
- Wyatt Nell
- Wylie John Jack
- Xu Xiangdong
- Xu Yong
- Yamanoue Hiroki
- Yamashita Takeshi
- Yang Tianlun
- Yao Jing
- Yeh Kuo-Ho
- Yin Wei Hsian
- Yotov Yoto
- Zahn Ralf
- Zanetti Fernando Lanas
- Zarich Stuart
- Zenin Sergei
- Zeuthen Elisabeth Louise
- Zhang Donghui
- Zhang Huanyi
- Zhang Jun
- Zhang Ping
- Zhang Xingwei
- Zhao Shui Ping
- Zhao Yujie
- Zhao Zhichen
- Zheng Yang
- Zhou Jing
- Zimmermann Sergio
- Zini Andrea
- Zizzo Steven
- Zong Wenxia
- Zukerman L Steven
- Publication venue
- Elsevier BV
- Publication date
- 01/01/2023
- Field of study
Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH
Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
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- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
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- Abbott D
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- Abd Elazeem HAS
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- Abdelkarem MM
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- on behalf of the COVIDSurg Collaborative
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- Turnage K
- Turnbull A
- Turrado-Rodriguez V
- Turri G
- Tustin H
- Tutoveanu G
- Tuveri M
- Tweedle E
- Tzedakis S
- Tzerbinis H
- Tzovaras G
- Ugarte-Sierra B
- Uludağ SS
- Umair M
- Umar M
- Underwood C
- Uno M
- Uras C
- Urbani A
- Urbieta A
- Usai A
- Usandivaras M
- Uslu G
- Uson-Bouthelier T
- Usseglio J
- Utkan NZ
- Uyanik MS
- Uzunoglu FG
- Vaccarella G
- Vahtsevanos K
- Valbuena Jabares V
- Valdes-Hernandez J
- Valente da Costa A
- Valero Soriano M
- Valero R
- Vallance A
- Vallance Abigail
- Valle Rubio A
- Valtzoglou V
- Valverde S
- Van den Eynde J
- Van den Eynde R
- van der Plas Willemijn
- Van Duijvendijk P
- Van Heinsbergen M
- Van Houdt W
- van Ramshorst Gabrielle H
- Van Wyngaard T
- Vanounou T
- Varazzani A
- Vargas L
- Varley I
- Varma M
- Vasljević J
- Vassiliu P
- Vatansever D
- Vatish J
- Vatish M
- Vaz Pereira R
- Vaz OP
- Vaz S
- Vazquez fernandez A
- Veiga D
- Velagapudi S
- Velchuru V
- Velickovic D
- Velidedeoglu M
- Venetis G
- Venn M
- Venn Mary L
- Venn Mary L.
- Venskutonis D
- Vera Mansilla C
- Verberne C
- Vergari R
- Vernon L
- Vervoort D
- Vescio G
- Vezakis A
- Vidakovic S
- Videira JF
- Videria Jose Flavio
- Vidya R
- Vidya Raghavan
- Vieira Caroço T
- Vieira Paiva Lopes AC
- Vieira A
- Vieira B
- Vieira P
- Vignali A
- Vigorita V
- Vijayan D
- Vilatoba M
- Vilendecic Z
- Villalabeitia Ateca I
- Vimalachandran D
- Vimalachandran Dale
- Vimalchandran Dale
- Vinayagam R
- Violante T
- Visgauss J
- Viswambaram P
- Viswanath Y
- Vitali A
- Vitone L
- Vives RV
- Vo UG
- Vogel J
- Vollkommer T
- Von Papen M
- Vovola F
- Vucic N
- Vujanac V
- Wade R
- Wadham B
- Waheed S
- Wai K
- Wali A
- Walker C
- Walker D
- Walkes K
- Wallwork K
- Walton G
- Walton T
- Waqar SH
- Warburton H
- Ward D
- Ward S
- Waris Farooka M
- Warren O
- Warren Oliver J
- Waseem S
- Wasim T
- Watson D
- Watson LJ
- Watson N
- Weaver H
- Webber L
- Wedderburn Duane
- Weitz J
- Welsch T
- Wensley F
- Werner J
- West C
- West D
- Westwood E
- Whelan M
- Whelan P
- Whisker L
- Whitehall E
- Whitmore H
- Wilkin R
- Wilkin Richard JW
- Wilkins A
- Wilkins Alex
- Williams G
- Williams J
- Williams K
- Williams MA
- Williams T
- Williamson K
- Wilson M
- Wimberger P
- Wimmer A
- Winnand P
- Winter D
- Winter S
- Winter Stuart C
- Wolfer S
- Wong MPK
- Wong S
- Wong WJ
- Woodham A
- Woodun H
- Worku D
- Wright G
- Wright Naomi
- Wullschleger M
- Wustrack R
- Xenaki S
- Xu MJ
- Xyda SE
- Xynos E
- Yahaya AS
- Yang W
- Yassin N
- Ye G
- Yesantharao P
- Yetkin G
- Yeşilyurt D
- Yiallourou A
- Yıldırım A
- Yildiz A
- Ying Y
- Yip V
- Yordanov S
- Young R
- Yousof EA
- Youssef A
- Youssef M
- Yurttas C
- Yánez C
- Yüksel E
- Zacharoulis D
- Zafar SN
- Zakai D
- Zakaria AD
- Zakaria R
- Zakaria Z
- Zambelli MF
- Zambon M
- Zamora L
- Zamvar V
- Zani S
- Zanotti S
- Zanus G
- Zapardiel I
- Zarabini AG
- Zegarac M
- Zelić M
- Zeller N
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zivanovic M
- Zivkovic M
- Zizzo M
- Zografos C
- Zonta S
- Zorrilla Ortúzar J
- Zourntou S
- Zouzoulas D
- Zubaidi A
- Zullo A
- Ângelo M
- Älgå A
- Çapoğlu R
- Çelebi F
- Çolak E
- Öfner D
- Öhlberger L
- Öğücü H
- Überrück L
- Ćoza I
- Šimko K
- Šćepanović V
- Žatecký J
- Камалов А
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study