Legislative Documents

Also, variously referred to as: Senate bills; Senate documents; Senate legislative documents; legislative documents; and General Court documents

Additional file 3: of Range-wide genetic analysis of Dermacentor variabilis and its Francisella-like endosymbionts demonstrates phylogeographic concordance between both taxa

Figure S2. Expanded maximum parsimony phylogeny of 32 Dermacentor variabilis from the USA based on the 16S rRNA gene. A consensus of five equally parsimonious trees is given illustrating a phylogenetic split within the greater D. variabilis population, which is congruent with the cox1 phylogeny. (EPS 2121 kb

Additional file 4: of Range-wide genetic analysis of Dermacentor variabilis and its Francisella-like endosymbionts demonstrates phylogeographic concordance between both taxa

Figure S3. Maximum parsimony phylogeny of 257 Francisella-like endosymbiont 16S rRNA gene sequences illustrates a distinct split within the endosymbionts, which mirrors the tick host. (EPS 4528 kb

Additional file 2: of Range-wide genetic analysis of Dermacentor variabilis and its Francisella-like endosymbionts demonstrates phylogeographic concordance between both taxa

Figure S1. Expanded maximum parsimony phylogeny of 332 Dermacentor variabilis from the USA and Canada based on the cox1 gene. A consensus of three equally parsimonious trees is given. Stars indicate samples for which mitochondrial 16S sequences were also generated. (EPS 1788 kb

Additional file 5: of Range-wide genetic analysis of Dermacentor variabilis and its Francisella-like endosymbionts demonstrates phylogeographic concordance between both taxa

Figure S4. Maximum parsimony phylogenetic analysis among six Francisella species and the Francisella-like endosymbionts from this study based on the 16S rRNA gene illustrates a high level of diversity among endosymbionts when compared to closely related Francisella species. (EPS 1279 kb

Additional file 6: of Range-wide genetic analysis of Dermacentor variabilis and its Francisella-like endosymbionts demonstrates phylogeographic concordance between both taxa

Figure S5. Maximum parsimony phylogenetic analysis of the OmpA gene in Rickettsia spp. isolated from Dermacentor variabilis. This phylogeny represents the three Rickettsia species and one Rickettsia-like endosymbiont detected during this study. (EPS 1202 kb

Central Nervous System Disposition and Metabolism of Fosdevirine (GSK2248761), a Non-Nucleoside Reverse Transcriptase Inhibitor: An LC-MS and Matrix-Assisted Laser Desorption/Ionization Imaging MS Investigation into Central Nervous System Toxicity

The CNS disposition and metabolism of Fosdevirine (FDV), an HIV non-nucleoside reverse transcriptase inhibitor, was investigated in four patients who unexpectedly experienced seizures after at least 4 weeks of treatment in a Phase IIb, HIV-1 treatment experienced study. In addition, the CNS disposition and metabolism of FDV was examined in samples from rabbit, minipig, and monkey studies. LC-MS was used to characterize and estimate the concentrations of FDV and its metabolites in cerebral spinal fluid (seizure patients, rabbit, and monkey) and brain homogenate (rabbit, minipig, and monkey). The application of matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) provided the spatial distribution of FDV and its metabolites in brain tissue (rabbit, minipig, and monkey). A cysteine conjugate metabolite resulting from an initial glutathione (GSH) Michael addition to the <i>trans</i>-phenyl acrylonitrile moiety of FDV was the predominant drug-related component in the samples from seizure patients, rabbits, and minipigs. This metabolite persisted in the CNS for an extended period of time after the last dose in both seizure patients and minipigs. Furthermore, the localization of this metabolite was found to be highly associated with the white matter in rabbit and minipig brain sections by MALDI IMS. In contrast, the predominant component in monkey CNS was FDV, which was shown to be highly associated with the gray matter. On the basis of these data, several hypothesizes are considered, which might provide insights into species differences in CNS toxicity/seizures observed after FDV dosing

dietBreadthArchived

Diet breadth data: each row indicates the number of herbivores ("Count") with a given diet breadth at a given site. Further details (such as species or family-level diet breadth) under the "Data" column