Domestic and International Pressures for European Agricultural Adjustment and Their Implications

General economic forces acting upon structural change in agriculture dominate the impacts of changes in agricultural policy. Particular factors are: (1) High demand for land for nonagricultural purposes. (2) High demand for residences in rural areas. (3) Demand for leisure space. (4) Changing occupational expectations and a move away from physical labour. Structural adjustment in agriculture is a steady process, driven by the enlargement of commercial farms and by the marginalisation of large numbers of smaller farms whose managers increasingly rely on off farm income and part-time operation. The most heavily commercial sector is becoming less dependent upon traditional support and more heavily influenced by the integrated contracts with downstream processors. The rate and direction of farm structure adjustment in the EU is unlikely to change as a consequence of any likely reforms in agricultural policy. The separation of EU farming into commercial and lifestyle/part-time operations lends itself to a two-track policy, with conservation and amenity output policy concentrated on the latter.Agricultural and Food Policy,

Gaining from Improved Dairy Cow Nutrition: Economic, environmental and animal health benefits

A majority of UK dairy herds have the potential to increase profitability by improving the ration of their cows. This paper reports that gains averaging around £100 per cow have been made within one year of adopting the Keenan Hi-Fibre ration by 239 UK herds in 2006 and 2007. Larger gains have been made by herds in France. The key performance indicator underlying these gains is Feed Conversion Efficiency, whereby the same, or even a smaller amount of Dry Matter Intake generates higher yields per cow. Importantly, the gains are associated with large improvements in animal health and reductions in greenhouse gases per litre of milk produced.Feed conversion efficiency, cattle nutrition, greenhouse gas emissions, animal health., Livestock Production/Industries,

Depositional History and Neotectonics in Great Salt Lake, Utah, from High-Resolution Seismic Stratigraphy

High-resolution seismic-reflection data from Great Salt Lake show that the basinal sediment sequence is cut by numerous faults with N–S and NE–SW orientations. This faulting shows evidence of varied timing and relative offsets, but includes at least three events totaling about 12 m following the Bonneville phase of the lake (since about 13.5 ka). Several faults displace the uppermost sediments and the lake floor. Bioherm structures are present above some faults, which suggests that the faults served as conduits for sublacustrine discharge of fresh water. A shallow, fault-controlled ridge between Carrington Island and Promontory Point, underlain by a well-cemented pavement, separates the main lake into two basins. The pavement appears to be early Holocene in age and younger sediments lap onto it. Onlap–offlap relationships, reflection truncations, and morphology of the lake floor indicate a low lake, well below the present level, during the early Holocene, during which most of the basin was probably a playa. This low stand is represented by irregular reflections in seismic profiles from the deepest part of the basin. Other prominent reflectors in the profiles are correlated with lithologic changes in sediment cores related to the end of the Bonneville stage of the lake, a thick mirabilite layer in the northern basin, and the Mazama tephra. Reflections below those penetrated by sediment cores document earlier lacustrine cycles

Valproate Protein Binding Is Highly Variable in ICU Patients and Not Predicted by Total Serum Concentrations: A Case Series and Literature Review

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/1/phar1912-sup-0001-SupInfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/2/phar1912_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/3/phar1912.pd

Cellular response to micropatterned growth promoting and inhibitory substrates

BACKGROUND: Normal development and the response to injury both require cell growth, migration and morphological remodeling, guided by a complex local landscape of permissive and inhibitory cues. A standard approach for studying by such cues is to culture cells on uniform substrates containing known concentrations of these molecules, however this method fails to represent the molecular complexity of the natural growth environment. RESULTS: To mimic the local complexity of environmental conditions in vitro, we used a contact micropatterning technique to examine cell growth and differentiation on patterned substrates printed with the commonly studied growth permissive and inhibitory substrates, poly-L-lysine (PLL) and myelin, respectively. We show that micropatterning of PLL can be used to direct adherence and axonal outgrowth of hippocampal and cortical neurons as well as other cells with diverse morphologies like Oli-neu oligodendrocyte progenitor cell lines and fibroblast-like COS7 cells in culture. Surprisingly, COS7 cells exhibited a preference for low concentration (1 pg/mL) PLL zones over adjacent zones printed with high concentrations (1 mg/mL). We demonstrate that micropatterning is also useful for studying factors that inhibit growth as it can direct cells to grow along straight lines that are easy to quantify. Furthermore, we provide the first demonstration of microcontact printing of myelin-associated proteins and show that they impair process outgrowth from Oli-neu oligodendrocyte precursor cells. CONCLUSION: We conclude that microcontact printing is an efficient and reproducible method for patterning proteins and brain-derived myelin on glass surfaces in order to study the effects of the microenvironment on cell growth and morphogenesis

A luminescent 1D silver polymer containing [2.2]paracyclophane ligands

Funding: UK EPSRC Grant Number(s) EP/P014082/1, EP/M02105X/1, EP/R035164/1).[2.2]Paracyclophane scaffolds have seen limited use as building blocks in supramolecular chemistry. Here, we report the synthesis and characterization of a 1D coordination polymer consisting of silver(I) ions bound to a [2.2]paracyclophane scaffold functionalized with two 4-pyridyl units. The structure of the polymer has been determined from single crystal X-ray diffraction analysis and reveals two different silver coordination motifs that alternate along the 1D coordination polymer. The coordination polymer exhibits strong blue and sky-blue fluorescence in solution and in the crystalline solid state, respectively.Publisher PDFPeer reviewe

Cadherin activity is required for activity-induced spine remodeling

Neural activity induces the remodeling of pre- and postsynaptic membranes, which maintain their apposition through cell adhesion molecules. Among them, N-cadherin is redistributed, undergoes activity-dependent conformational changes, and is required for synaptic plasticity. Here, we show that depolarization induces the enlargement of the width of spine head, and that cadherin activity is essential for this synaptic rearrangement. Dendritic spines visualized with green fluorescent protein in hippocampal neurons showed an expansion by the activation of AMPA receptor, so that the synaptic apposition zone may be expanded. N-cadherin-venus fusion protein laterally dispersed along the expanding spine head. Overexpression of dominant-negative forms of N-cadherin resulted in the abrogation of the spine expansion. Inhibition of actin polymerization with cytochalasin D abolished the spine expansion. Together, our data suggest that cadherin-based adhesion machinery coupled with the actin-cytoskeleton is critical for the remodeling of synaptic apposition zone