581 research outputs found

    Towards a quality framework for localized FC relaxometry

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    Non peer reviewedPublisher PD

    A long-term in vitro silicon-based microelectrode-neuron connection

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    A novel method for long-term recording and simulation applicable to cultured neurons has been developed. Silicon-based microelectrodes have been fabricated using integrated-circuit technology and micromachining. The chronic connection is made by positioning the tip of the `diving-board electrode' into contact with the top of the cell body. The electrode support structure is then glued to the bottom of the culture dish. Two-way electrical connections to Helisoma B19 neurons have been maintained for up to four days. This capability makes it possible to conduct experiments that are not practical using conventional techniques

    Error propagation in fast field-cycling relaxometry

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    Peer reviewedPublisher PD

    Persistent emotional disorder in children with neurological soft signs

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    Provides clinical details in the form of 11 case vignettes from a prospective epidemiological study that found the combination of childhood \u27soft\u27 signs and anxious behavior to be a strong risk factor for adolescent emotional disorders. The original study conducted a neuropsychiatric assessment of 180 African-American adolescents (aged 16–18 yrs) who had been followed through childhood. The at-risk Ss exhibited a persistent and specific pattern of both motor abnormalities and anxiety, obsessional compulsive, or depressive symptoms over time. The form of at-risk Ss\u27 neurological and psychiatric abnormalities is consistent with a link between motor system abnormalities and emotional disorders
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